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L-655,708

L-655,708 structure

CAS No.: 130477-52-0

Chemical Name:: L-655,708

Synonyms: MSD;L-655,708;L 655708,L655708;ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE;Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate;11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester;(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate;11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg)

CBNumber:: CB4345633

Molecular Formula:: C18H19N3O4

Molecular Weight:: 341.36

MDL Number:: MFCD02684528

MOL File:: 130477-52-0.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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L-655,708 Properties

Melting point	175-176 °C
Boiling point	584.4±50.0 °C(Predicted)
Density	1.42±0.1 g/cm3(Predicted)
storage temp.	Desiccate at +4°C
solubility	DMSO: 6 mg/mL
form	powder
pka	1.49±0.20(Predicted)
FDA UNII	L4BX842T8C

SAFETY

Risk and Safety Statements

WGK Germany	3

L-655,708 price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	L9787	L-655,708 ≥98% (HPLC), powder	130477-52-0	5mg	$131	2024-03-01	Buy
Sigma-Aldrich	L9787	L-655,708 ≥98% (HPLC), powder	130477-52-0	25mg	$522	2024-03-01	Buy
Cayman Chemical	30322	L-655,708	130477-52-0	5mg	$106	2024-03-01	Buy
Cayman Chemical	30322	L-655,708	130477-52-0	50mg	$570	2024-03-01	Buy
Cayman Chemical	30322	L-655,708	130477-52-0	10mg	$167	2024-03-01	Buy

Product number	Packaging	Price	Buy
L9787	5mg	$131	Buy
L9787	25mg	$522	Buy
30322	5mg	$106	Buy
30322	50mg	$570	Buy
30322	10mg	$167	Buy

L-655,708 Chemical Properties,Uses,Production

Uses

L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.

Biological Activity

Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in? a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

Biochem/physiol Actions

L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.

storage

Desiccate at +4°C

L-655,708 Preparation Products And Raw materials

Raw materials

Preparation Products

L-655,708 Suppliers

Global( 63)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19994	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	sales@bicbiotech.com	China	6000	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Labnetwork lnc.	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Nanjing Bicbiotechnology Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69

130477-52-0(L-655,708)Related Search:

[3H]-L-655,708,L-655,708, [1',1',1'-3H] 2-(1H-IMIDAZOL-1-YL)BENZENECARBOXAMIDE 2-IMIDAZOL-1-YL-BENZALDEHYDE 4-(5-METHYL-1H-IMIDAZOL-1-YL)PHENOL 4-(1H-IMIDAZOL-4-YL)-BUTYLAMINE

1-[2-(1H-IMIDAZOL-1-YL)PHENYL]METHANAMINE L-655,708

1of2

9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- 9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg) MSD Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate 11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester 11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER L-655,708 ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE (S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate L 655708,L655708 130477-52-0 GABA/Glycine receptor