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N-Methyl-N-(trimethylsilyl)acetamide

CAS No.
7449-74-3
Chemical Name:
N-Methyl-N-(trimethylsilyl)acetamide
Synonyms
N-METHYL-N-TRIMETHYLSILYLACETAMIDE;MOUSE ALBUMIN;N-Methyl-N-TMS-acetamide;[TriMethylsilylating Agent];N-METHYL-N-TRIMETHYLSILYACETAMIDE;N-TRIMETHYLSILYL-N-METHYLACETAMIDE;N-Methyl-N-trimethylsilylacetamine;n-methyl-n-(trimethylsilyl)-acetamid;MSA~N-Trimethylsilyl-N-methylacetamide;Acetamide,N-methyl-N-(trimethylsilyl)-
CBNumber:
CB4355232
Molecular Formula:
C6H15NOSi
Molecular Weight:
145.27
MDL Number:
MFCD00040758
MOL File:
7449-74-3.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

N-Methyl-N-(trimethylsilyl)acetamide Properties

Boiling point 159-161 °C(lit.)
Density 0.904 g/mL at 20 °C(lit.)
refractive index n20/D 1.439
Flash point 48 °C
storage temp. -20°C
form lyophilized powder
pka -0.11±0.70(Predicted)
color Clear light yellow
Specific Gravity 0.906
Sensitive Moisture Sensitive
BRN 506975
CAS DataBase Reference 7449-74-3(CAS DataBase Reference)
FDA UNII W0IWF6UKW5
NIST Chemistry Reference Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3)
EPA Substance Registry System Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS02,GHS07
Signal word  Warning
Hazard statements  H314-H315-H319-H335-H226
Precautionary statements  P261-P303+P361+P353-P305+P351+P338-P501a-P210-P233-P240-P241+P242+P243-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P403+P235-P405-P501
Hazard Codes  Xi
Risk Statements  10-36/37/38
Safety Statements  37/39-16
RIDADR  UN 1993 3/PG 3
WGK Germany  3
10-21
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29319090
NFPA 704
2
2 0

N-Methyl-N-(trimethylsilyl)acetamide price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 69480 N-Methyl-N-trimethylsilylacetamide for GC derivatization, ≥97.0% (GC) 7449-74-3 10ml $189 2022-05-15 Buy
TCI Chemical M0536 N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) 7449-74-3 10g $92 2024-03-01 Buy
TCI Chemical M0536 N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] >95.0%(GC) 7449-74-3 25g $179 2024-03-01 Buy
Alfa Aesar L04101 N-Methyl-N-trimethylsilylacetamide, 98% 7449-74-3 2g $28.65 2024-03-01 Buy
Alfa Aesar L04101 N-Methyl-N-trimethylsilylacetamide, 98% 7449-74-3 10g $69.65 2024-03-01 Buy
Product number Packaging Price Buy
69480 10ml $189 Buy
M0536 10g $92 Buy
M0536 25g $179 Buy
L04101 2g $28.65 Buy
L04101 10g $69.65 Buy

N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties,Uses,Production

Chemical Properties

clear light yellow liquid

Uses

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:???????

  • Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.???????
  • Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

General Description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).

Purification Methods

N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]

N-Methyl-N-(trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 148)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830 figo.gao@foxmail.com China 6992 58
Chongqing Chemdad Co., Ltd
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career henan chemical co
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Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com China 9339 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
Alfa Chemistry
+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503259 +86-19930503259 cherry@crovellbio.com China 18456 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 49999 58

View Lastest Price from N-Methyl-N-(trimethylsilyl)acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Methyl-N-trimethylsilylacetamide pictures 2021-07-13 N-Methyl-N-trimethylsilylacetamide
7449-74-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
N-Methyl-N-trimethylsilylacetamide pictures 2021-07-10 N-Methyl-N-trimethylsilylacetamide
7449-74-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
N-Methyl-N-(trimethylsilyl)acetamide pictures 2020-01-13 N-Methyl-N-(trimethylsilyl)acetamide
7449-74-3
US $3.00 / KG 1KG 98% 200KG Career Henan Chemical Co
N-Methyl-N-TMS-acetamide N-Methyl-N-trimethylsilyl-acetamide(MSA) MSA~N-Trimethylsilyl-N-methylacetamide N-Methyl-N-trimethylsilyacetamideMSA(N-Trimethylsilyl-N-methylacetamide) N-Methyl-N-trimethylsilylacetamine N-Methyl-N-(trimethylsilyl)acetamide,98% N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] [TriMethylsilylating Agent] N-Methyl-N-triMethylsilylacetaMide  N-METHYL-N-TRIMETHYLSILYACETAMIDE N-TRIMETHYLSILYL-N-METHYLACETAMIDE MOUSE ALBUMIN n-methyl-n-(trimethylsilyl)-acetamid Acetamide,N-methyl-N-(trimethylsilyl)- 1-(4-phenylmethoxyphenyl)-2-propanamine N-Methyl-N-trimethylsilylacetamide[TrimethylsilylatingAgent]> N-METHYL-N-TRIMETHYLSILYLACETAMIDE 7449-74-3 C6H15NOSi Si (Classes of Silicon Compounds) Silylacetamides Si-N Compounds Silylation (GC Derivatizing Reagents) Trimethylsilylation (GC Derivatizing Reagents) GC Derivatizing Reagents Derivatization Reagents Fluka Reagents Analytical Chromatography Product Catalog Analytical Chemistry GC Derivatizing Reagents Si (Classes of Silicon Compounds) Silylacetamides Silylation (GC Derivatizing Reagents) Si-N Compounds Trimethylsilylation (GC Derivatizing Reagents)