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2,6-Dimethylfluorobenzene

2,6-Dimethylfluorobenzene Structure
2,6-Dimethylfluorobenzene structure
CAS No.
443-88-9
Chemical Name:
2,6-Dimethylfluorobenzene
Synonyms
2-FLUORO-1,3-DIMETHYLBENZENE;2-FLUORO-M-XYLENE;Fluoroxylene3;FLUORO-M-XYLENE;2-Fluoro-m-xylene>2-Fluoro-m-xylene,98%;2,6-DIMETHYLFLUOROBENZENE;2,5-DIMETHYLFLUOROBENZENE;1-FLUORO-2,6-DIMETHYLBENZENE;1,3-dimethyl-2-fluorobenzene
CBNumber:
CB4367264
Molecular Formula:
C8H9F
Molecular Weight:
124.16
MDL Number:
MFCD00039215
MOL File:
443-88-9.mol
MSDS File:
SDS
Last updated:2026-01-13 11:19:48
Product description Number Pack Size Price
2-Fluoro-1,3-dimethylbenzene 97% 452866 5ml $87.3
2-Fluoro-m-xylene >98.0%(GC) F0402 5g $38
2-Fluoro-m-xylene >98.0%(GC) F0402 25g $183
2,6-Dimethylfluorobenzene D465758 100mg $45
2,6-Dimethylfluorobenzene D465758 500mg $65
More product size
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2,6-Dimethylfluorobenzene Properties

Boiling point 147-148 °C(lit.)
Density 0.988 g/mL at 25 °C(lit.)
refractive index n20/D 1.479(lit.)
Flash point 87 °F
storage temp. 2-8°C
form liquid
color Clear, colourless
Specific Gravity 0.988
Water Solubility Not miscible or difficult to mix in water.
BRN 1857413
InChI InChI=1S/C8H9F/c1-6-4-3-5-7(2)8(6)9/h3-5H,1-2H3
InChIKey JTAUTNBVFDTYTI-UHFFFAOYSA-N
SMILES C1(C)=CC=CC(C)=C1F
CAS DataBase Reference 443-88-9(CAS DataBase Reference)
NIST Chemistry Reference 2,6-Dimethylfluorobenzene(443-88-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Warning
Hazard statements  H226
Precautionary statements  P261-P210-P233-P240-P241+P242+P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  F,Xn
Risk Statements  10
Safety Statements  16
RIDADR  UN 1993 3/PG 3
WGK Germany  3
Hazard Note  Flammable
HazardClass  3
PackingGroup  III
HS Code  29039990
Storage Class 3 - Flammable liquids
Hazard Classifications Flam. Liq. 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
0 0

2,6-Dimethylfluorobenzene price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 452866 2-Fluoro-1,3-dimethylbenzene 97% 443-88-9 5ml $87.3 2023-06-20 Buy
TCI Chemical F0402 2-Fluoro-m-xylene >98.0%(GC) 443-88-9 5g $38 2026-03-19 Buy
TCI Chemical F0402 2-Fluoro-m-xylene >98.0%(GC) 443-88-9 25g $183 2026-03-19 Buy
TRC D465758 2,6-Dimethylfluorobenzene 443-88-9 100mg $45 2021-12-16 Buy
TRC D465758 2,6-Dimethylfluorobenzene 443-88-9 500mg $65 2021-12-16 Buy
Product number Packaging Price Buy
452866 5ml $87.3 Buy
F0402 5g $38 Buy
F0402 25g $183 Buy
D465758 100mg $45 Buy
D465758 500mg $65 Buy

2,6-Dimethylfluorobenzene Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid

Uses

It is used in the spectroscopic observation of jet-cooled 2-fluoro-m-xylyl radical.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 21, p. 906, 1978 DOI: 10.1021/jm00207a013

Synthesis

2,6-Dimethylaniline

87-62-7

2,6-Dimethylfluorobenzene

443-88-9

Example 2: General procedure for synthesizing 2-fluoro-1,3-dimethylbenzene from 2,6-dimethylaniline The diazotization of 2,6-dimethylaniline (2.3 g, 0.02 mol) was carried out in an Et3N-3HF system under the same conditions as for 2,4,6-trimethylaniline in Example 1. Upon initial addition of sodium nitrite (2.0 g, 0.03 mol), the color of the reaction mixture gradually changed from yellow to red. A small amount of tar is generated during the reaction, which can be easily separated by solvent extraction. The post-treatment was consistent with the description of 2,4,6-trimethylaniline. The organic layer was extracted from the aqueous phase using diethyl ether (150 mL), and the organic extract was dried over magnesium sulfate and fractionated by solvent to give an orange colored oil. The oily substance was distilled at 141-143 °C and atmospheric pressure to give the colorless liquid 1-fluoro-2,6-dimethylbenzene (2.0 g, 86.3% yield). The distillation process was completed in 1 hour. The 1H NMR (CDCl3) spectrum of the product showed: δ 2.25 (2-CH3 and 6-CH3, d, J = 2.0 Hz, 6H); δ 6.91 (3-H and 5-H, dd, J = 8.3 Hz and J = 6.5 Hz, 2H); and δ 7.01 (4-H, t, J = 8.0 Hz, 1H).19F NMR (CDCl3) spectrum was found to be at δ 122.5 (1-F, ts, J = 6.5 Hz and J = 2.0 Hz) showed signals. Mass spectrometry analysis showed the molecular ion peak at m/z 124 and characteristic fragmentation peaks of 1-fluoro-2,6-dimethylbenzene were observed at m/z 109, 103, 96, 89, 83 and 77.

References

[1] Patent: US6179970, 2001, B2
[2] Journal of the American Chemical Society, 1992, vol. 114, # 7, p. 2482 - 2494
[3] Proceedings - Indian Academy of Sciences, Section A, 1959, vol. 50, p. 51,56, 58, 59
[4] Journal of Medicinal Chemistry, 1978, vol. 21, # 9, p. 906 - 913
[5] Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1995, vol. 50, # 7, p. 1075 - 1078

2,6-Dimethylfluorobenzene synthesis

87-62-7
443-88-9
Synthesis of 2,6-Dimethylfluorobenzene from 2,6-Dimethylaniline

2,6-Dimethylfluorobenzene Preparation Products And Raw materials

Raw materials

(2,6-dimethylphenyl) chloroformate 1,3-Dimethyl-4-fluorobenzene 3-Methylbenzyl fluoride 2,4,6-TRIMETHYLFLUOROBENZENE 4-(TERT-BUTYL)-2,6-DIMETHYLANILINE
2,6-Dimethylphenylboronic acid 4-TERT-BUTYL-2,6-DIMETHYLNITROBENZENE 2-Iodo-1,3-dimethylbenzene 1,2,4-Trichlorobenzene 2-Bromo-m-xylene
2,6-Dimethylaniline 1-tert-Butyl-3,5-dimethylbenzene m-Xylene

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Preparation Products

4-FLUORO-3,5-DIMETHYLANILINE 1,3-Benzenedicarboxaldehyde,2-fluoro-(9CI) 2-Fuoro-5-iodo-1,3-dimethylbenzene

2,6-Dimethylfluorobenzene Suppliers

Global( 222)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10404 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
Richest Group Ltd 		18017061086 oled@richest-group.com CHINA 5600 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Fluoropharm Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Richest Group Ltd 		58

View Lastest Price from 2,6-Dimethylfluorobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,6-dimethylfluorobenzene pictures 2026-04-23 2,6-dimethylfluorobenzene
443-88-9
 US $20.00 / ASSAYS 1ASSAYS 99% 200MT/ year Speranza Chemical Co., Ltd.
2,6-Dimethylfluorobenzene pictures 2026-03-20 2,6-Dimethylfluorobenzene
443-88-9
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2,6-Dimethylfluorobenzene pictures 2025-09-25 2,6-Dimethylfluorobenzene
443-88-9
 US $100.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

2,6-Dimethylfluorobenzene Spectrum

2,6-Dimethylfluorobenzene(443-88-9)MS2,6-Dimethylfluorobenzene(443-88-9)1HNMR2,6-Dimethylfluorobenzene(443-88-9)13CNMR2,6-Dimethylfluorobenzene(443-88-9)FT-IR

443-88-9(2,6-Dimethylfluorobenzene)Related Search:

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FLUORO-M-XYLENE 2,5-DIMETHYLFLUOROBENZENE 2,6-DIMETHYLFLUOROBENZENE Benzene, 2-fluoro-1,3-dimethyl- Fluoromxylenedimethylfluorobenzene Fluoroxylene3 1-FLUORO-2,6-DIMETHYLBENZENE 1,3-Dimethyl-2-fluorobenzene~2,6-Dimethylfluorobenzene 2-Fluoro-m-xylene,98% 2-Fluoro-m-xylene,1,3-Dimethyl-2-fluoroBenzene 1,3-dimethyl-2-fluorobenzene 2,6-Dimethylfluorobenzene 98% 2,6-Dimethylfluorobenzene98% 2,6-Dimethyl-1-fluorobenzene 2,6-Dimethylfluorobenzene 2-Fluoro-1,3-dimethylbenzene 1,3-Dimethyl-2-fluorobenzene 98% 2-Fluoro-m-xylene> 2,6-Dimethylfluorobenzene ISO 9001：2015 REACH 2-FLUORO-1,3-DIMETHYLBENZENE 2-FLUORO-M-XYLENE 443-88-9 443-89-9 433-88-9 CH32C6H3F Building Blocks Aryl C8 Organic Building Blocks Halogenated Hydrocarbons Halogen toluene