Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Cynaroside

Cynaroside

Cynaroside Structure
Cynaroside structure
CAS No.
5373-11-5
Chemical Name:
Cynaroside
Synonyms
LUTEOLIN-7-O-GLUCOSIDE;luteoloside;PETUNIDIN;LUTEOLIN-7-GLUCOSIDE;Galuteolin;cinaroside;glucoluteolin;Luteolin 7-O-β-D-glucopyranoside;4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(.beta.-D-glucopyranosyloxy)-5-hydroxy-;Cyroside
CBNumber:
CB4369516
Molecular Formula:
C21H20O11
Molecular Weight:
448.38
MDL Number:
MFCD06799436
MOL File:
5373-11-5.mol
Last updated:2025-12-11 08:41:34
Product description Number Pack Size Price
Luteolin 7-glucoside phyproof? Reference Substance PHL89724 20mg $368
Luteolin 7-O-Glucoside United States Pharmacopeia (USP) Reference Standard 1370837 30mg $586
Luteolin 7-glucoside primary pharmaceutical reference standard 03600585 10mg $485
Luteoloside ≥98% 25141 5mg $93
Luteoloside ≥98% 25141 10mg $130
More product size
Request For Quotation

Cynaroside Properties

Melting point 256～258℃
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
Boiling point 838.1±65.0 °C(Predicted)
Density 1.713±0.06 g/cm3(Predicted)
pka 6.10±0.40(Predicted)
form Solid
color Yellow to Very Dark Yellow
Stability Hygroscopic
InChIKey PEFNSGRTCBGNAN-QNDFHXLGSA-N
SMILES C1(C2=CC=C(O)C(O)=C2)OC2=C(C(O)=CC(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)=C2)C(=O)C=1 |&1:17,18,20,22,24,r|
LogP -0.090 (est)
CAS DataBase Reference 5373-11-5(CAS DataBase Reference)
FDA UNII 98J6XDS46I
UNSPSC Code 85151701
NACRES NA.28

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
RTECS  DJ3009400
HS Code  29389090

Cynaroside price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL89724 Luteolin 7-glucoside phyproof? Reference Substance 5373-11-5 20mg $368 2025-07-31 Buy
Sigma-Aldrich 1370837 Luteolin 7-O-Glucoside United States Pharmacopeia (USP) Reference Standard 5373-11-5 30mg $586 2025-07-31 Buy
Sigma-Aldrich 03600585 Luteolin 7-glucoside primary pharmaceutical reference standard 5373-11-5 10mg $485 2025-07-31 Buy
Cayman Chemical 25141 Luteoloside ≥98% 5373-11-5 5mg $93 2024-03-01 Buy
Cayman Chemical 25141 Luteoloside ≥98% 5373-11-5 10mg $130 2024-03-01 Buy
Product number Packaging Price Buy
PHL89724 20mg $368 Buy
1370837 30mg $586 Buy
03600585 10mg $485 Buy
25141 5mg $93 Buy
25141 10mg $130 Buy

Cynaroside Chemical Properties,Uses,Production

Effects

Luteolin has a strong bactericidal effect on the respiratory tract, and it is the main active ingredient in the treatment of bronchitis in Qinglan, a unique medicinal material in Xinjiang. Lowers the role of cholesterol in atherosclerosis and enhances capillary relaxation.

Description

Luteolin-7-O-glucoside is a flavonoid that has been found in many Chinese herbs with diverse biological activities. It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC50 = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC50 = 0.43 mM). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod .

Chemical Properties

Off-white powder

Uses

Luteolin 7-Glucoside is a strong antioxidant ant radical scavenger. Used in cancer prevention.

Definition

ChEBI: A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

in vivo

Cynaroside (i.p.; 5mg/kg) reduces binding of PKM2 to hypoxia-inducible factor-1α (HIF-1α) by abolishing translocation of PKM2 to the nucleus and promoting PKM2 tetramer formation, as well as suppressing phosphorylation of PKM2 at Y105[2].

Animal Model:Mice model of sepsis[2]
Dosage:5mg/kg
Administration:Cynaroside (i.p.; 5mg/kg)
Result:Inhibited PKM2 dimer formation in liver of septic mice.

References

[1] ZHANTU LIU. Luteoloside attenuates anoxia/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14-3-3η protein.[J]. Phytotherapy Research, 2018, 32 6: 1126-1134. DOI: 10.1002/ptr.6053
[2] ZEYU CAO. Luteoloside Acts as 3C Protease Inhibitor of Enterovirus 71 In Vitro.[J]. PLoS ONE, 2016, 11 1: e0148693. DOI: 10.1371/journal.pone.0148693
[3] SHAO-HUA FAN. Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome.[J]. PLoS ONE, 2014: e89961. DOI: 10.1371/journal.pone.0089961
[4] R PALOMBO. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model[J]. Cell Death & Disease, 2016, 7 8: e2344-e2344. DOI: 10.1038/cddis.2016.201

Cynaroside Preparation Products And Raw materials

Raw materials

Preparation Products

Cynaroside Suppliers

Global( 334)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Biopurify Phytochemicals Ltd.
+86-28-82633860; +8618080483897 sales@biopurify.com China 3751 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29845 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Supplier Advantage
Chengdu Biopurify Phytochemicals Ltd.
58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Chengdu GLP biotechnology Co Ltd 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58

View Lastest Price from Cynaroside manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cynaroside pictures 2025-12-15 Cynaroside
5373-11-5
 US $30.00-105.00 / mg 99.73% 10g TargetMol Chemicals Inc.
Cynaroside pictures 2025-12-15 Cynaroside
5373-11-5
 US $0.00 / g 10g 98% 2 Changsha Staherb Natural Ingredients Co., Ltd.
Cynaroside pictures 2025-06-27 Cynaroside
5373-11-5
 US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
  • Cynaroside pictures
  • Cynaroside
    5373-11-5
  • US $30.00-105.00 / mg
  • 99.73%
  • TargetMol Chemicals Inc.
  • Cynaroside pictures
  • Cynaroside
    5373-11-5
  • US $0.00 / g
  • 98%
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Cynaroside pictures
  • Cynaroside
    5373-11-5
  • US $0.00-0.00 / KG
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

Cynaroside Spectrum

Cynaroside(5373-11-5)1HNMR

5373-11-5(Cynaroside)Related Search:

Luteolin CHLOROPHOSPHONAZO III BETA-GLUCOSIDASE AMYLOGLUCOSIDASE Taxifolin
luteolin-7-glucuronide Luteolin-3'-D-glucuronide alkyl polyglucoside Ranolazine PETUNIDIN CHLORIDE
Diosmin petunidin-3-O-glu,PETUNIDIN3-O-GLUCOSIDE ALPHA-BOSWELLIC ACID QUERCETIN-7-O-GLUCOSIDE LUTEOLIN-7,3'-DI-O-DIGLUCURONIDE
nepitrin OCTYL GLUCOSIDE linariifolioside

1of4

LUTEOLIN-7-O-GLUCOSIDE 98+% luteolin7-o-glucopyranoside CYNAROSIDE LUTEOLIN-7-O-GLUCOSIDE WITH HPLC 7-β-D-Glucosylluteolin Nephrocizin Nephrocizine Luteoloside，Cynaroside，Galuteolin，Glucoluteolin Luteolin 7-β-D-glucopyranoside Luteolin 7-b-glucoside lCynaroside Daphneflavonoloside Flavopurposide LUTEOLIN-7-GLUCOSIDE hplc 2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one Luteolin 7-O-D-glucoside LUTEOLIN-7-O-GLUCOSIDE(P) Luteolin 7-beta-glucoside Luteolin-7-O-D-glucopyranoside, froM Gentiana Macrophylla Cynaroside Luteolin 7-O-D-glucoside 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-7-(b-D-glucopyranosyloxy)-5-hydroxy- luteolin 7-O-beta-D-glucoside 2-(3,4-dihydroxyphenyl)-7-(beta-d-glucopyranosyloxy)-5-hydroxy-4h-1-benzopyr 4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-7-(beta-d-glucopyranosyloxy)-5-h 7-glucoluteolin 7-glucosylluteolin luteolin7-monoglucoside Luteolin-7-O-D-glucopyranoside, 98%, from Gentiana macrophylla 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(β-D-glucopyranosyloxy)-5-hydroxy- GLUCOLUTEOLIN; LUTEOLOSIDE; CINAROSIDE; LUTEOLIN 7-GLUCOSIDE;LUTEOLIN 7-O-Β-D-GLUCOSIDE Luteolin-7-O-β-D-glucopyranoside, 98%, from Gentiana macrophylla Pall. 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one luteolin7-O-β-D-glucoside Cynaroside USP/EP/BP 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(.beta.-D-glucopyranosyloxy)-5-hydroxy- luteoloside LUTEOLIN-7-GLUCOSIDE LUTEOLIN-7-O-GLUCOSIDE Luteolin 7-O-β-D-glucopyranoside Galuteolin PETUNIDIN cinaroside glucoluteolin Cynaroside (Luteolin 7-glucoside) Luteoloside (Cynaroside) Luteoloside Luteolin 7-glucoside Luteolin 7-glucoside-RM Luteolin-7-O-Glucoside(Cynaroside)(AS) Cynaroside, 10 mM in DMSO Luteolin 7-O-β-D-glucoside Luteolin 7-glucoside [Storage:2℃±4℃, Purity:98%min. Luteolin-7-O-glucoside 1000 μg/mL in Ethanol Cyroside Luteolin-7-O-glucoside /Cynaroside 5373-11-5 5375-11-5 1268-79-8 chemical reagent