DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE
- CAS No.
- 150113-99-8
- Chemical Name:
- DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE
- Synonyms
- FURIN INHIBITOR I;DECANOYL-RVKR-CMK;DECANOYL-ARG-VAL-LYS-ARG-CMK;Furin Inhibitor I, Dec-RVKR-CMK;Decanoyl-Arg-Val-Lys-Arg-CMK·TFA;DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE;Furin Convertase Inhibitor ( Chloromethylketone);L-Lysinamide, N2-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-
- CBNumber:
- CB4374716
- Molecular Formula:
- C34H66ClN11O5
- Molecular Weight:
- 744.41
- MDL Number:
- MFCD00798792
- MOL File:
- 150113-99-8.mol
- MSDS File:
- SDS
DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 344930 | Furin Inhibitor I Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. | 1mg | $230 | 2024-03-01 | Buy | |
| Sigma-Aldrich | 344930 | Furin Inhibitor I Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. | 1MG | $223 | 2023-06-20 | Buy | |
| Cayman Chemical | 14965 | Furin Inhibitor I ≥95% | 150113-99-8 | 500μg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 14965 | Furin Inhibitor I ≥95% | 150113-99-8 | 1mg | $157 | 2024-03-01 | Buy |
| Cayman Chemical | 14965 | Furin Inhibitor I ≥95% | 150113-99-8 | 5mg | $728 | 2024-03-01 | Buy |
DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE Chemical Properties,Uses,Production
Uses
N2-(1-Oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-L-lysinamide is a Furin inhibitor that may be used in the inhibition of the Chikungunya virus (CHIKV), a mosquito-transmitted Alphavirus that causes in humans an acute infection characterized by polyarthralgia, fever, myalgia, and headache
Definition
ChEBI: Decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone is a tetrapeptide consisting of N-decanoyl-L-arginine, L-valine, L-lysine, and L-arginine joined in sequence by peptide linkages and in which the carboxy group at the C-terminus is substituted by a chloroacetyl group. It is a furin inhibitor that has antiviral activity against Chikungunya virus, Zika virus and Japanese encephalitis virus. It has a role as an antiviral agent, a peptidomimetic and an EC 3.4.21.75 (furin) inhibitor. It is a tetrapeptide and an organochlorine compound.
Biological Activity
decanoyl-rvkr-cmk is a proprotein convertase inhibitor [1].proprotein convertases (pcs) are involved in generating bioactive peptides, as well as activating several enzymes and growth factors in many important physiological events. pcs play important roles in several pathologies including viral infections and cancers. thus, pcs are promising targets for therapeutic applications [1].in pc12 cells, the pc enzyme inhibitor decanoyl-rvkr-cmk at ~ 100 μm, resulted in partial block of regulated vgf release at 48 h and a complete block at 96 h, without significant change in basal vgf release. also, decreased vgf processing was observed in cell extracts and media from decanoyl-rvkr-cmk-treated pc12 cultures [2].in k5-pace4 transgenic mice topically treated with the hyperplasiogenic phorbol ester 12-o-tetradecanoylphorbol-13-acetate (tpa), a 2-day topical treatment of decanoyl-rvkr-cmk at 300 μm, inhibited tpa-induced epidermal proliferation. when decanoyl-rvkr-cmk treatment (100 μm, q.d.) was extended for 3 weeks, decreasing numbers of ki-67-labeled cells were shown in both k5-pace4 mice epidermal basal epidermal keratinocytes and wild-type mouse epidermis [3].[1]. fugère m, day r. cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition. trends in pharmacological sciences, 2005, 26(6): 294-301.[2]. garcia a l, han s k, janssen w g, et al. a prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide vgf into the regulated secretory pathway. journal of biological chemistry, 2005, 280(50): 41595-41608.[3]. bassi d e, zhang j, cenna j, et al. proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis. neoplasia, 2010, 12(7): 516-526.
storage
Store at -20°C
DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE Preparation Products And Raw materials
Raw materials
Preparation Products
DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696; | info@hanhongsci.com | China | 42982 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6084 | 56 | |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9365 | 58 |