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AFC

AFC structure

CAS No.: 135304-07-3

Chemical Name:: AFC

Synonyms: AFC;AFC USP/EP/BP;AC-CYS(FARNESYL)-OH;Ac-L-Cys(Farnesyl)-OH;AC-CYSTEINE(FARNESYL)-OH;N-Acetyl-L-farnesylcysteine;n-acetyl-s-farnesylcysteine;ACETYL-S-FARNESYL-L-CYSTEINE;N-ACETYL-S-FARNESYL-L-CYSTEINE;N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE

CBNumber:: CB4379892

Molecular Formula:: C20H33NO3S

Molecular Weight:: 367.55

MDL Number:: MFCD00871540

MOL File:: 135304-07-3.mol

MSDS File:: SDS

Last updated:2023-06-08 09:03:09

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AFC Properties

Boiling point	566.1±50.0 °C(Predicted)
Density	1.038±0.06 g/cm3(Predicted)
storage temp.	-15°C
solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
pka	3.31±0.10(Predicted)
form	Pale yellow oil.
color	Yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
LogP	5.860 (est)
FDA UNII	KK6984C8O3

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H319-H336

Precautionary statements

P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501

HazardClass

IRRITANT

NFPA 704

	3
2		0

AFC price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	63270	N-acetyl-S-farnesyl-L-Cysteine ≥98%	135304-07-3	1mg	$32	2024-03-01	Buy
Cayman Chemical	63270	N-acetyl-S-farnesyl-L-Cysteine ≥98%	135304-07-3	5mg	$78	2024-03-01	Buy
Cayman Chemical	63270	N-acetyl-S-farnesyl-L-Cysteine ≥98%	135304-07-3	10mg	$139	2024-03-01	Buy
Cayman Chemical	63270	N-acetyl-S-farnesyl-L-Cysteine ≥98%	135304-07-3	25mg	$305	2024-03-01	Buy
TRC	A765560	Arazine	135304-07-3	10mg	$80	2021-12-16	Buy

Product number	Packaging	Price	Buy
63270	1mg	$32	Buy
63270	5mg	$78	Buy
63270	10mg	$139	Buy
63270	25mg	$305	Buy
A765560	10mg	$80	Buy

AFC Chemical Properties,Uses,Production

Description

N-acetyl-S-farnesyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

Chemical Properties

Yellow-red oil

Uses

Arazine is an FTS (trans-Farnesylthiosalicylic Acid) compound, which does not inhibit EJ cell growth and does not affect Ras.

Definition

ChEBI: Acetyl-farnesyl-cysteine is a sesquiterpenoid.

References

1) Volker?et al.?(1991),?Effects of farnesylcyteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem.?266?21515 2) Xu?et al.?(1996),?Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol.?50?1495 3) Rosado and Sage (2000),?Farnesylcyteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J.?347?183 4) Gordon?et al.?(2008),?Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol.?128?643 5) Adhami?et al.?(2012),?N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells;?Exp. Dermatol.?21?700

AFC synthesis

Synthesis of AFC from (E,E)-Farnesol

AFC Preparation Products And Raw materials

Raw materials

FARNESYL CYSTEINE AC-CYS(FARNESYL)-OME N-Acetyl-L-cysteine (E,E)-Farnesol Acetic anhydride

Preparation Products

AFC Suppliers

Global( 66)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
BOC Sciences	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nextpeptide Inc	58
LEAP CHEM CO., LTD.	58
GIHI CHEMICALS CO.,LIMITED	58

135304-07-3(AFC)Related Search:

AC-CYS(FARNESYL)-OME Z-ARG-ARG-AFC Z-IETD-AFC,Z-ILE-GLU-THR-ASP-AFC AFC FA-CYS(FARNESYL)-OH

N-ACETYL-S-GERANYLGERANYL-L-CYSTEINE Z-ASP-GLN-MET-ASP-AFC,Z-DQMD-AFC Z-VAL-LYS-LYS-ARG-AFC,Z-VKKR-AFC Z-RGFFL-AFC HCL,Z-ARG-GLY-PHE-PHE-LEU-AFC HCL Z-ALA-AFC

Z-MET-AFC Z-LYS-AFC Z-GGR-AFC,Z-GLY-GLY-ARG-AFC Z-ALA-ALA-ASP-AFC Z-VAL-GLU-ILE-ASP-AFC,Z-VEID-AFC

VLR-AFC VLK-AFC Z-GLY-PRO-ARG-AFC,Z-GRP-AFC

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AFC AC-CYSTEINE(FARNESYL)-OH AC-CYS(FARNESYL)-OH ACETYL-S-FARNESYL-L-CYSTEINE N-ACETYL-S-(3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENYL)-L-CYSTEINE N-ACETYL-S-FARNESYL-L-CYSTEINE N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE n-acetyl-s-farnesylcysteine N-Acetyl-S-farnesyl-L-cysteine (AFC) N-Acetyl-L-farnesylcysteine N-Acetyl-S-trans,trans-farnesyl-L-cysteine Acetyl-S-farnesyl-L-cysteine≥ 99% (TLC) Ac-L-Cys(Farnesyl)-OH N-Acetyl-S-(3,7,11-trimethyl-2ε,6ε,10-dodecatrienyl)-L-cysteine L-Cysteine,N-acetyl-S-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]- (R)-2-acetamido-3-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio) propanoic acid AFC USP/EP/BP 135304-07-3 163479-47-3 C20H33NO3S