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CGP 20712 A

CGP 20712 A Structure
CGP 20712 A structure
CAS No.
105737-62-0
Chemical Name:
CGP 20712 A
Synonyms
CGP207122HCl;CGP 20712 mesylate;CGP 20712 DIHYDROCHLORIDE;CGP-20712A methanesulfonate salt;CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE;CGP-20712A methanesulfonate salt solid, >=98% (HPLC);1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd;1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate;1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE;(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate
CBNumber:
CB4380786
Molecular Formula:
C24H29F3N4O8S
Molecular Weight:
590.57
MDL Number:
MFCD06798358
MOL File:
105737-62-0.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:13
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CGP 20712 A Properties

storage temp. 2-8°C
solubility H2O: 10 mg/mL
form solid
color white
FDA UNII CNU8DA2K9J

SAFETY

Risk and Safety Statements

WGK Germany  3

CGP 20712 A price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C231 CGP-20712A methanesulfonate salt solid, ≥98% (HPLC) 105737-62-0 10mg $195.6 2024-03-01 Buy
Sigma-Aldrich C231 CGP-20712A methanesulfonate salt solid, ≥98% (HPLC) 105737-62-0 50mg $1270 2023-01-07 Buy
Tocris 1024 CGP20712dihydrochloride ≥96%(HPLC) 105737-62-0 50 $936 2021-12-16 Buy
Tocris 1024 CGP20712dihydrochloride ≥96%(HPLC) 105737-62-0 10 $227 2021-12-16 Buy
Usbiological 254932 CGP 20712 dihydrochloride 105737-62-0 10mg $480 2021-12-16 Buy
Product number Packaging Price Buy
C231 10mg $195.6 Buy
C231 50mg $1270 Buy
1024 50 $936 Buy
1024 10 $227 Buy
254932 10mg $480 Buy

CGP 20712 A Chemical Properties,Uses,Production

Uses

CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles.

Biological Activity

Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Biochem/physiol Actions

CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.

in vitro

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.

in vivo

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.

CGP 20712 A Preparation Products And Raw materials

Raw materials

Preparation Products

CGP 20712 A Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
HBCChem, Inc. +1-510-219-6317 sales@hbcchem.com United States 10658 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 9945 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223 psaitong@jm-bio.com China 29834 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
HBCChem, Inc. 60
Sigma-Aldrich 80
DC Chemicals 58
Energy Chemical 58
cjbscvictory 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

105737-62-0(CGP 20712 A )Related Search:

2-Methyl-4-trifluoromethylimidazole CGP 20712 A 1-(2-HYDROXY-ETHYLAMINO)-3-PHENOXY-PROPAN-2-OL 4-(Trifluoromethyl)-1H-imidazole 2-Phenyl-4-(trifluoromethyl)-1H-imidazole
2-(4-ETHOXY-PHENYL)-1H-IMIDAZOLE

1of2

CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE 1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd CGP207122HCl CGP-20712A methanesulfonate salt (±)-2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl] amino]ethoxy]-benzamide methanesulfonate salt 1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE CGP 20712 DIHYDROCHLORIDE CGP 20712 mesylate 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate (+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate CGP-20712A methanesulfonate salt solid, >=98% (HPLC) 105737-62-0 C23H25F3N4O5CH4O3S C23H25F3N4O52HCl C24H27F3N4O7S Adrenoceptor