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Riboflavin structure
Chemical Name:
Hyre;Q 14;E 101;VIT B2;RIBIPCA;Flaxain;Ribosyn;Ribovel;Hyflavin;Beflavin
Molecular Formula:
Formula Weight:
MOL File:

Riboflavin Properties

Melting point:
290 °C (dec.)(lit.)
-135 º (c=5, 0.05 M NaOH)
Boiling point:
504.93°C (rough estimate)
1.2112 (rough estimate)
refractive index 
-135 ° (C=0.5, JP Method)
Flash point:
storage temp. 
Very slightly soluble in water, practically insoluble in ethanol (96 per cent). Solutions deteriorate on exposure to light, especially in the presence of alkali. It shows polymorphism (5.9).
1.7(at 25℃)
Yellow to orange
5.5-7.2 (0.07g/l, H2O, 20°C)
Water Solubility 
0.07 g/L (20 ºC)
Light Sensitive
Stable, but light-sensitive. Incompatible with strong oxidizing agents, reducing agents, bases, calcium, metallic salts. May be moisture sensitive.
CAS DataBase Reference
83-88-5(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  24/25-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
RTECS  VJ1400000
HS Code  29362300
Hazardous Substances Data 83-88-5(Hazardous Substances Data)
Toxicity LD50 in rats (g/kg): >10 orally, 5.0 s.c., 0.56 i.p. (Unna, Greslin)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Riboflavin price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1054 Riboflavin Pharmaceutical Secondary Standard; Certified Reference Material 83-88-5 1g $62.3 2018-11-20 Buy
Sigma-Aldrich 1603006 Riboflavin United States Pharmacopeia (USP) Reference Standard 83-88-5 500mg $357.7 2018-11-13 Buy
TCI Chemical R0020 Riboflavin 83-88-5 25g $31 2018-11-22 Buy
TCI Chemical R0020 Riboflavin 83-88-5 100g $92 2018-11-22 Buy
Alfa Aesar A11764 Riboflavin, 98% 83-88-5 100g $52.2 2018-11-13 Buy

Riboflavin Chemical Properties,Uses,Production

Chemical Properties

Yellow to orange/yellow crystalline powd


Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).


Vitamin B2; Vitamin cofactor; LD50(rat) 560 mg/kg ip


riboflavin (Vitamin B2) is used in skin care preparations as an emollient. It can be found in sun care products as a suntan enhancer. Medicinally, it is used for the treatment of skin lesions.


Riboflavin is the water-soluble vitamin b2 required for healthy skin and the building and maintaining of body tissues. it is a yellow to orange-yellow crystalline powder. it acts as a coenzyme and carrier of hydrogen. it is stable to heat but may dissolve and be lost in cooking water. it is relatively stable to storage. sources include leafy vegetables, cheese, eggs, and milk.


ChEBI: D-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety. It is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vege ables, but the richest natural source is yeast. The free form occurs only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

brand name

Flavaxin (Sterling Winthrop).

General Description

The conflicting results were eventually found to be due,in part, to deficiencies in study animals not just of vitamin B2,but also vitamin B3 (niacin), the cause of human forms of pellagra,and/or vitamin B6 (pyridoxine), another cause of dermatitis.Likewise, treatments with vitamin B2 were inconsistentbecause the early sources of this vitamin contained otherB vitamins. Vitamin B2 was eventually isolated from eggwhites in 1933 and produced synthetically in 1935. Thename riboflavine was officially accepted in 1960; althoughthe term was in common use before then. In 1966, IUPACchanged it to riboflavin, which is in common use today.Riboflavin is synthesized by all green plants and by mostbacteria and fungi. Therefore, riboflavin is found, at least insmall amounts, in most foods. Foods that are naturally highin riboflavin include milk and other dairy products, meat,eggs, fatty fish, and dark green vegetables.
Chemically, riboflavin is an N-glycoside of flavin, alsoknown as lumichrome, and the sugar, ribitol .Flavin is derived from the Latin word flavus for “yellow”because of the yellow color of its crystals and yellow fluorescenceunder UV light. Riboflavin is heat stable but easilydegraded by light. Its systematic names are 7,8-dimethyl-10-ribitylisoalloxazine and 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine.

Clinical Use

Severe riboflavin deficiency is known as ariboflavinosis, andtreatment or prevention of this condition is the only provenuse of riboflavin. Ariboflavinosis is most commonly associatedwith multiple vitamin deficiency as a result of alcoholismin developed countries. Because of the large numberof enzymes requiring riboflavin as a coenzyme, deficienciescan lead to a wide range of abnormalities. In adults seborrheicdermatitis, photophobia, peripheral neuropathy, anemia, andoropharyngeal changes including angular stomatitis, glossitis,and cheilosis, are often the first signs of riboflavin deficiency.In children, cessation of growth can also occur. As the deficiencyprogresses, more severe pathologies develop untildeath ensues. Riboflavin deficiency may also produce teratogeniceffects and alter iron handling leading to anemia.

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

It crystallises from H2O as a yellow-orange powder in three different forms with differing amounts of H2O. It melts if placed in an oil bath at 250o, but decomposes at 280o if heated at a rate of 5o/minute. It is also purified by crystallisation from 2M acetic acid, then extracted with CHCl3 to remove lumichrome impurity. [Smith & Metzler J Am Chem Soc 85 3285 1963.] Its solubility in H2O is 1g in 3-15L depending on the crystal structure. Its solubility in EtOH at 25o is 4.5mg in 100mL. Store it in the dark because it is decomposed to lumichrome by UV light. [Pearson The Vitamins vol V pp1-96 1967 and vol VII pp 1-96 1972, and Pearson eds, Academic Press, Beilstein 26 IV 2542.]

Riboflavin Preparation Products And Raw materials

Raw materials

Preparation Products

Riboflavin Suppliers

Global( 409)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
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View Lastest Price from Riboflavin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Riboflavin
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-24 Riboflavin
US $625.00 / G 10G 99% customise career henan chemical co
2019-01-21 Riboflavin
US $50.00 / Kg 1Kg 99% 5000kg Hebei Chisure Biotechnology Co., Ltd.

Riboflavin Spectrum

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