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L(-)-Pipecolinic acid

Description
L(-)-Pipecolinic acid
L(-)-Pipecolinic acid structure
CAS No.
3105-95-1
Chemical Name:
L(-)-Pipecolinic acid
Synonyms
L-Hip;PIP-OH;h-pip-oh;L-HOMOPRO;NSC 93089;EOS-61735;H-L-PIP-OH;H-HOPRO-OH;H-PIC(2)-OH;HOMOPROLINE
CBNumber:
CB4393366
Molecular Formula:
C6H11NO2
Formula Weight:
129.16
MOL File:
3105-95-1.mol

L(-)-Pipecolinic acid Properties

Melting point:
272 °C(lit.)
alpha 
-27.5 º (c=5, H2O 24 ºC)
Boiling point:
239.22°C (rough estimate)
Density 
1.1426 (rough estimate)
refractive index 
-27 ° (C=4, H2O)
storage temp. 
Store at RT.
pka
2.28(at 25℃)
form 
Fine Crystalline Powder
color 
White
optical activity
[α]25/D 26.4°, c = 1 in H2O
Water Solubility 
soluble
Merck 
14,7458
BRN 
81093
InChIKey
HXEACLLIILLPRG-YFKPBYRVSA-N
CAS DataBase Reference
3105-95-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
HS Code  29339900
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

L(-)-Pipecolinic acid price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 237752 L-Pipecolic acid Proline homolog., 99% 3105-95-1 100mg $121 2018-11-13 Buy
Sigma-Aldrich P2519 L-Pipecolic acid 99% (titration) 3105-95-1 1g $584 2018-11-13 Buy
TCI Chemical P1404 L-Pipecolic Acid >98.0%(T) 3105-95-1 1g $112 2018-11-22 Buy
TCI Chemical P1404 L-Pipecolic Acid >98.0%(T) 3105-95-1 5g $389 2018-11-22 Buy
Alfa Aesar L15373 L-Pipecolinic acid, 99% 3105-95-1 1g $90.1 2018-11-13 Buy

L(-)-Pipecolinic acid Chemical Properties,Uses,Production

Description

L-Pipecolinic acid is involved in synaptic transmission in the central nervous system. It is also used as pharmaceutical intermediate. It is a lysine metabolite; defect in its catabolism is involved in hyperpipecolic acidemia, cerebro-hepato-renal syndrome, neonatal onset adrenoleukodystrophy, and infantile Refsum disease. It can be associated with some forms of epilepsy. CRYM, a taxon-specific crystallin protein that also binds thyroid hormones, is involved in the pipecolic acid pathway.

Chemical Properties

white to light yellow crystal powde

Uses

Pipecolic acid is involved in synaptic transmission in the central nervous system. The l-form occurs in plants.

Definition

ChEBI: A pipecolate that is the conjugate acid of L--pipecolic acid.

Enzyme inhibitor

This amino acid (FW = 129.16 g/mol; CAS 3105-95-1), also called 2- piperidinecarboxylic acid and pipecolinic acid, is readily prepared from lysine and can be regarded as a proline homologue. The L-enantiomer has been identified in mushrooms, fruits, malt, and seeds. Elevated levels of pipecolate (i.e., hyperpipecolic acidemia) have been observed in certain inborn errors in metabolism. Note that the pKa values of pipecolic acid are 2.28 and 10.72; hence, under most aqueous conditions, this molecule exists as a zwitterion. The L-isomer is a product of the reaction catalyzed by D1- piperideine-2-carboxylate reductase and is a substrate for L-pipecolate oxidase and L-pipecolate dehydrogenase. Target (s) : bovine leukemia virus retropepsin; and proline racemase, weakly inhibited.

Purification Methods

It crystallises from water. The (±)-picrate has m 158-159o (from EtOH or C6H6). [Beilstein 22 H 7, 22 III/IV 97, 22/1 V 220.] The R(+)-enantiomer [1723-00-8] has m 277o(dec) and [] D 20 +27o (c 4, H2O), and the S(-)-enantiomer [3105-95-1] has m 277o(dec) and [] D 20 -26o (c 4, H2O).[cf p 603, Beilstein 22 III/IV 96, 22/1 V 220.]

L(-)-Pipecolinic acid Preparation Products And Raw materials

Raw materials

Preparation Products


L(-)-Pipecolinic acid Suppliers

Global( 291)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Anhui Dexinjia Biopharm Co., Ltd
86-531-82375818
86-531-82375893 alice@jndxj.com CHINA 129 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
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Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
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+86-0592-6210733 sales@mainchem.com CHINA 32457 55
ATK CHEMICAL COMPANY LIMITED
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
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+8613091036086; +8613292890173
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career henan chemical co
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View Lastest Price from L(-)-Pipecolinic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 L(-)-Pipecolinic acid
3105-95-1
US $8.00 / kg 1kg 99% 10MT career henan chemical co
2019-01-21 L(-)-Pipecolinic acid
3105-95-1
US $10.00-10.00 / Kg 1Kg 99% 500tons/month Hebei Chisure Biotechnology Co., Ltd.

L(-)-Pipecolinic acid Spectrum


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