YANGONIN
- CAS No.
- 500-62-9
- Chemical Name:
- YANGONIN
- Synonyms
- Yan;Y100550;YANGONIN;11-METHOXYYANGONIN;Yangoninpproved, it should be;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-on;Yangonin, 98%, from Piper methysticum Forst;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-one;4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one;4-methoxy-6-(beta-(p-anisyl)vinyl)-alpha-pyrone
- CBNumber:
- CB4393593
- Molecular Formula:
- C15H14O4
- Molecular Weight:
- 258.27
- MDL Number:
- MFCD00221733
- MOL File:
- 500-62-9.mol
Melting point | 155-157° |
---|---|
Boiling point | 487.6±45.0 °C(Predicted) |
Density | 1.325 g/cm3 |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
color | Pale Yellow to Pale Green |
BRN | 230710 |
Stability | Light Sensitive |
LogP | 1.750 (est) |
FDA UNII | R970U49V3C |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
YANGONIN price More Price(25)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 75575 | Yangonin analytical standard | 500-62-9 | 5MG | $501 | 2022-05-15 | Buy |
Cayman Chemical | 14351 | Yangonin ≥98% | 500-62-9 | 1mg | $62 | 2024-03-01 | Buy |
Cayman Chemical | 14351 | Yangonin ≥98% | 500-62-9 | 5mg | $180 | 2024-03-01 | Buy |
Cayman Chemical | 14351 | Yangonin ≥98% | 500-62-9 | 10mg | $270 | 2024-03-01 | Buy |
Cayman Chemical | 14351 | Yangonin ≥98% | 500-62-9 | 25mg | $595 | 2024-03-01 | Buy |
YANGONIN Chemical Properties,Uses,Production
Uses
A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.
Description
Yangonin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline at the γ-amino butyric acid (GABA) receptor GABAA at 1.0 μM. Yangonin also binds the central cannabinoid (CB1) receptor with a Ki value of 0.72 μM, but whether it serves as an agonist or antagonist at this receptor remains to be determined. Yangonin blocks the activation of NF-κB by TNF-α. It also inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL).
Uses
A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.
Uses
A lactone isolated from the Kava plant (Piper methysticum). rokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety d isorders. a supplements.
Definition
ChEBI: Yangonin is a member of 2-pyranones and an aromatic ether.
YANGONIN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |