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YANGONIN

CAS No.
500-62-9
Chemical Name:
YANGONIN
Synonyms
Yan;Y100550;YANGONIN;11-METHOXYYANGONIN;Yangoninpproved, it should be;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-on;Yangonin, 98%, from Piper methysticum Forst;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-one;4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one;4-methoxy-6-(beta-(p-anisyl)vinyl)-alpha-pyrone
CBNumber:
CB4393593
Molecular Formula:
C15H14O4
Molecular Weight:
258.27
MDL Number:
MFCD00221733
MOL File:
500-62-9.mol
Last updated:2023-06-08 09:03:03

YANGONIN Properties

Melting point 155-157°
Boiling point 487.6±45.0 °C(Predicted)
Density 1.325 g/cm3
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
color Pale Yellow to Pale Green
BRN 230710
Stability Light Sensitive
LogP 1.750 (est)
FDA UNII R970U49V3C

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
WGK Germany  3
NFPA 704
0
1 0

YANGONIN price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 75575 Yangonin analytical standard 500-62-9 5MG $501 2022-05-15 Buy
Cayman Chemical 14351 Yangonin ≥98% 500-62-9 1mg $62 2024-03-01 Buy
Cayman Chemical 14351 Yangonin ≥98% 500-62-9 5mg $180 2024-03-01 Buy
Cayman Chemical 14351 Yangonin ≥98% 500-62-9 10mg $270 2024-03-01 Buy
Cayman Chemical 14351 Yangonin ≥98% 500-62-9 25mg $595 2024-03-01 Buy
Product number Packaging Price Buy
75575 5MG $501 Buy
14351 1mg $62 Buy
14351 5mg $180 Buy
14351 10mg $270 Buy
14351 25mg $595 Buy

YANGONIN Chemical Properties,Uses,Production

Uses

A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.

Description

Yangonin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline at the γ-amino butyric acid (GABA) receptor GABAA at 1.0 μM. Yangonin also binds the central cannabinoid (CB1) receptor with a Ki value of 0.72 μM, but whether it serves as an agonist or antagonist at this receptor remains to be determined. Yangonin blocks the activation of NF-κB by TNF-α. It also inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL).

Uses

A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.

Uses

A lactone isolated from the Kava plant (Piper methysticum). rokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety d isorders. a supplements.

Definition

ChEBI: Yangonin is a member of 2-pyranones and an aromatic ether.

YANGONIN Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 146)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3424 58
Xi'an Kono chem co., Ltd.,
029-86107037 13289246953 info@konochemical.com China 2995 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shanghai Standard Technology Co., Ltd.
18502101150 ft-sales@nature-standard.com CHINA 1923 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-519-519-85557386 marketing1@neostarunited.com China 8349 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879 sales@chemnorm.com CHINA 2935 58

View Lastest Price from YANGONIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Yangonin pictures 2023-02-24 Yangonin
500-62-9
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
	YANGONIN pictures 2019-07-06 YANGONIN
500-62-9
US $1.00 / kg 1g 99% 100KG Career Henan Chemical Co
  • Yangonin pictures
  • Yangonin
    500-62-9
  • US $0.00 / mg
  • ≥98%(HPLC)
  • Shanghai Standard Technology Co., Ltd.
  • 	YANGONIN pictures
  • YANGONIN
    500-62-9
  • US $1.00 / kg
  • 99%
  • Career Henan Chemical Co
YANGONIN 11-METHOXYYANGONIN 4-methoxy-6-(beta-(p-anisyl)vinyl)-alpha-pyrone 4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-on 4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-one 5-hydroxy-3-methoxy-7-(p-methoxyphenyl)-2,4,6-heptatrienoicacidgamma-lacton 4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one 4-Methoxy-6-[(E)-2-(4-methoxyphenyl)vinyl]-2H-pyran-2-one 4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one Yan Yangoninpproved, it should be Yangonin, 98%, from Piper methysticum Forst Y100550 (E)-4-Methoxy-6-(4-methoxystyryl)-2H-pyran-2-one 2H-Pyran-2-one, 4-methoxy-6-[(1E)-2-(4-methoxyphenyl)ethenyl]- 500-62-9 500-62-0 C15H14O4 Aromatics Heterocycles Mutagenesis Research Chemicals