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Tolnaftate

Tolnaftate
Tolnaftate structure
CAS No.
2398-96-1
Chemical Name:
Tolnaftate
Synonyms
Aftate;Pitrex;sorgoa;Tritin;Focusan;Timoped;Tinavet;Dermoxin;sch10144;Tinactin
CBNumber:
CB4396231
Molecular Formula:
C19H17NOS
Formula Weight:
307.41
MOL File:
2398-96-1.mol

Tolnaftate Properties

Melting point:
110.5-111.5°C
Density 
1.1328 (rough estimate)
refractive index 
1.6970 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in chloroform at 50 mg/ml. Sparingly soluble in ethanol or methanol
form 
powder
color 
white to off-white
Water Solubility 
<0.1 g/100 mL at 22 ºC
λmax
258nm(MeOH)(lit.)
Merck 
14,9519
InChIKey
FUSNMLFNXJSCDI-UHFFFAOYSA-N
NIST Chemistry Reference
Tolnaftate(2398-96-1)
EPA Substance Registry System
Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester(2398-96-1)

SAFETY

WGK Germany  2
RTECS  FD8891300
TSCA  Yes
HazardClass  IRRITANT
Toxicity LD50 in mice, rats (g/kg): >10, >6 orally; >6, >4 s.c. (Hashimoto)

Tolnaftate price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1778 Tolnaftate Pharmaceutical Secondary Standard; Certified Reference Material 2398-96-1 1g $113 2018-11-20 Buy
Sigma-Aldrich 1671006 Tolnaftate United States Pharmacopeia (USP) Reference Standard 2398-96-1 200mg $352.8 2018-11-20 Buy
TCI Chemical T3059 Tolnaftate >97.0%(HPLC)(N) 2398-96-1 1g $42 2018-11-22 Buy
TCI Chemical T3059 Tolnaftate >97.0%(HPLC)(N) 2398-96-1 5g $146 2018-11-22 Buy
Alfa Aesar J61834 Tolnaftate 2398-96-1 5g $154 2018-11-13 Buy

Tolnaftate Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

antifungal for cutaneous infections

Uses

Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and po

Definition

ChEBI: A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.

General Description

Crystals or white powder.

Air & Water Reactions

Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. Insoluble in water.

Reactivity Profile

Tolnaftate is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.

Health Hazard

SYMPTOMS: In susceptible persons, Tolnaftate may cause sensitization or irritation.

Fire Hazard

Flash point data on Tolnaftate are not available, Tolnaftate is probably combustible.

Clinical Use

O,2-Naphthyl m,N-dimethylthiocarbanilate (Tinactin,Aftate, NP-27) is a white crystalline solid that is insoluble inwater, sparingly soluble in alcohol, and soluble in most organicsolvents. The compound, a thioester of β-naphthol, isfungicidal against dermatophytes, such as Trichophyton,Microsporum, and Epidermophyton spp., that cause superficialtinea infections. Tolnaftate is available in a concentrationof 1% in creams, powders, aerosols, gels, and solutionsfor the treatment of ringworm, jock itch, and athlete’s foot.Tolnaftate has been shown to act as an inhibitor of squaleneepoxidase in susceptible fungi, so it is classified with theallylamine antimycotics. Tolnaftate is formulated into preparationsintended to be used with artificial fingernails to counteractthe increased chance of ringworm of the nail beds.

Clinical Use

Tolnaftate (Tinactin, others) is a nonprescription antifungal agent effective in the topical treatment of dermatophyte infections and tinea. The mechanism of action is unknown.

Safety Profile

Mtldly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of SOx and NOx. A fungicide used to control athlete's foot. See also ESTERS and CARBAMATES.

Tolnaftate Preparation Products And Raw materials

Raw materials

Preparation Products


Tolnaftate Suppliers

Global( 193)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21830 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 211 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23957 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20084 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8267 58

View Lastest Price from Tolnaftate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-21 Tolnaftate
2398-96-1
US $7.00 / kg 1kg 99% 100kg career henan chemical co
2018-05-24 tolnaftate
2398-96-1
US $10.00 / KG 10G 99% 1000kg Meihua Biological Technology Co.,Ltd

2398-96-1(Tolnaftate)Related Search:


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