Disodium clodronate tetrahydrate
- CAS No.
- 88416-50-6
- Chemical Name:
- Disodium clodronate tetrahydrate
- Synonyms
- Clodronate (sodium salt hydrate);BONEFOS;CLASTEON;CLASTOBAN;CLODRONATE DISODIUM SALT;Ceftobiprole Impurity 11;Disodium clodronate tetrahydrate;Clodronate disodiuM(tetrehydrate);DisodiumClodronateTetrahydrate>CLODRONATE, DISODIUM, TETRAHYDRATE
- CBNumber:
- CB4404653
- Molecular Formula:
- CH7Cl2NaO7P2
- Molecular Weight:
- 286.9
- MDL Number:
- MFCD02940846
- MOL File:
- 88416-50-6.mol
| storage temp. | 2-8°C |
|---|---|
| solubility | Soluble in Water (up to at least 10 mg/ml) |
| form | White solid |
| color | White |
| Merck | 14,2371 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| InChIKey | XWHPUCFOTRBMGS-UHFFFAOYSA-L |
| FDA UNII | N030400H8J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361-H332-H412-H302 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P273-P501-P201-P202-P281-P308+P313-P405-P501 | |||||||||
| RTECS | SZ7640700 | |||||||||
| HS Code | 2931.39.0030 | |||||||||
| NFPA 704 |
|
Disodium clodronate tetrahydrate price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000888 | Clodronate disodium tetrahydrate European Pharmacopoeia (EP) Reference Standard | 88416-50-6 | y0000888 | $153 | 2024-03-01 | Buy |
| Sigma-Aldrich | 233183 | Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem | 88416-50-6 | 10mg | $142 | 2024-03-01 | Buy |
| TCI Chemical | D4160 | Disodium Clodronate Tetrahydrate >98.0%(T) | 88416-50-6 | 1g | $91 | 2024-03-01 | Buy |
| TCI Chemical | D4160 | Disodium Clodronate Tetrahydrate >98.0%(T) | 88416-50-6 | 5g | $311 | 2024-03-01 | Buy |
| Cayman Chemical | 16134 | Clodronate (sodium salt hydrate) ≥95% | 88416-50-6 | 5mg | $37 | 2024-03-01 | Buy |
Disodium clodronate tetrahydrate Chemical Properties,Uses,Production
Description
Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 μM, inhibiting their growth (IC50 = 1.34 μM) and bone resorption. Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts. Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.
Uses
Disodium Clodronate Tetrahydrate is a bisphosphonate bone growth regulator.
Definition
ChEBI: The tetrahydrate of the disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions nd bone pain associated with skeletal metastases.
References
1) Plosker and Goa (1994), Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease; Drugs 47 945 2) Lehenkari et al. (2002), Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite; Mol.Pharmacol. 61 1255
Disodium clodronate tetrahydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Disodium clodronate tetrahydrate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 | info@fortunachem.com | China | 5985 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from Disodium clodronate tetrahydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-20 | Disodium dichloromethylenebis(hydrogenphosphonate) tetrahydrate
88416-50-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-02-24 | Disodium clodronate tetrahydrate
88416-50-6
|
US $0.00 / g | 5g | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2021-09-29 | Disodium clodronate tetrahydrate
88416-50-6
|
US $0.00 / Kg/Bag | 10g | 98%-101% | 10KGS | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Disodium dichloromethylenebis(hydrogenphosphonate) tetrahydrate
88416-50-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Disodium clodronate tetrahydrate
88416-50-6
- US $0.00 / g
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Disodium clodronate tetrahydrate
88416-50-6
- US $0.00 / Kg/Bag
- 98%-101%
- WUHAN FORTUNA CHEMICAL CO., LTD
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