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ChemicalBook >> CAS DataBase List >>3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Structure
3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one structure
CAS No.
714240-31-0
Chemical Name:
3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one
Synonyms
NCGC00029283;NCGC00029283,NCGC-00029283;3-(5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2-ol;3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one;2(1H)-Quinolinone, 3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-
CBNumber:
CB44083407
Molecular Formula:
C18H12FN3O3
Molecular Weight:
337.3
MDL Number:
MFCD05729526
MOL File:
714240-31-0.mol
Last updated:2023-09-04 15:51:00
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3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Properties

Density 1.365±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 9.37±0.70(Predicted)

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Chemical Properties,Uses,Production

Biological Activity

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1]. NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1].

References

[1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Suppliers

Global( 17)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42057 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9708 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 3616 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
SINO High Goal Chemical Technology Co., Ltd. 021-57646680 18306277365 guoxin@chembiobanksh.com China 2332 58
Chengdu PEIP Pharmaceutical Technology Co., LTD. 028-61715638 18011352545 1242335275@qq.com China 401 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
Changzhou Furuisi Biotechnology Co., Ltd 58
SINO High Goal Chemical Technology Co., Ltd. 58
Chengdu PEIP Pharmaceutical Technology Co., LTD. 58
TargetMol Chemicals Inc. 58

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one Spectrum

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one(714240-31-0)1HNMR
3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one NCGC00029283 NCGC00029283,NCGC-00029283 2(1H)-Quinolinone, 3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy- 3-(5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2-ol 714240-31-0