ChemicalBook
Chinese Japanese Germany Korea

DL-10-CAMPHORSULFONIC ACID

Overview Preparation Resolution Uses Market References
DL-10-CAMPHORSULFONIC ACID
DL-10-CAMPHORSULFONIC ACID structure
CAS No.
5872-08-2
Chemical Name:
DL-10-CAMPHORSULFONIC ACID
Synonyms
¥1,450,959.00;ChaMphorsulfonic acid;10-CAMPHORSULFONIC ACID;DL-CAMPHORSULFONIC ACID;Voriconazole IMpurity E;(±)-Camphor-10-sulfonate;CAMPHOR-10-SULFONIC ACID;Campho 10 Sulphonic Acid;DL-10-CAMPHORSULFONIC ACID;D,L-Camphor sulphonic acid
CBNumber:
CB4408868
Molecular Formula:
C10H16O4S
Formula Weight:
232.3
MOL File:
5872-08-2.mol

DL-10-CAMPHORSULFONIC ACID Properties

Melting point:
203-206 °C (dec.)(lit.)
Boiling point:
344.46°C (rough estimate)
alpha 
[α]D20 0.0±0.3° (c=5, H2O)
Density 
1.2981 (rough estimate)
refractive index 
1.5400 (estimate)
storage temp. 
2-8°C
form 
Granular Powder
color 
Slightly beige
Water Solubility 
Soluble in water.
Sensitive 
Hygroscopic
BRN 
3205973
Stability:
Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
InChIKey
MIOPJNTWMNEORI-UHFFFAOYSA-N
CAS DataBase Reference
5872-08-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45-27
RIDADR  UN 3261 8/PG 2
WGK Germany  3
RTECS  DT5077100
3-10
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29147000
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

DL-10-CAMPHORSULFONIC ACID price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 147923 Camphor-10-sulfonic acid (β) 98% 5872-08-2 100g $38.8 2018-11-13 Buy
Sigma-Aldrich 147923 Camphor-10-sulfonic acid (β) 98% 5872-08-2 500g $142 2018-11-13 Buy
TCI Chemical C0016 (+/-)-10-Camphorsulfonic Acid >98.0%(T) 5872-08-2 25g $18 2018-11-22 Buy
TCI Chemical C0016 (+/-)-10-Camphorsulfonic Acid >98.0%(T) 5872-08-2 100g $33 2018-11-22 Buy
Alfa Aesar A12620 (±)-Camphor-10-sulfonic acid, 98% 5872-08-2 100g $35.9 2018-11-13 Buy

DL-10-CAMPHORSULFONIC ACID Chemical Properties,Uses,Production

Overview

DL-Camphorsulfonic acid, also known as camphorsulfonic acid, is a white or almost white crystalline powder. The molecular formula of camphorsulfonic acid is C10H16O4S. It is a pair of chiral optical enantiomers with prismatic crystals, divided into left-handed camphorsulfonic acid and right-handed camphorsulfonic acid. The melting point is 193~195 ℃ and 197~200 ℃, respectively. Camphorsulfonic acid is a derivative of camphor, widely used in medicine, light industry and cosmetic industry. At present, its application mainly focused on chiral asymmetric synthesis, high selective catalysis of natural products and polymer doping with polyaniline to prepare nano-scale conductive polymer materials.
left-right isomer of camphorsulfonic acid
Figure 1: left-right isomer of camphorsulfonic acid

Preparation

natural camphor is mainly extracted from camphor plants, ginger plants and sage seeds, and with optical activity; synthetic camphor is generally prepared by the isomerization of turpentine to obtain camphene, then by esterification, hydrolysis and dehydrogenation reaction process; synthetic camphor is racemic, almost lacking optical activity. Through the reaction of camphor powder and concentrated sulfuric acid sulfonation, racemic camphorsulfonic acid is obtained, and then by the resolution, left and right handed camphorsulfonic acid is made. The optimum conditions for the synthesis of camphorsulfonic acid are as follows: the molar ratio of camphor powder, concentrated sulfuric acid and acetic anhydride is 1.0: 1.4: 3.0; reaction temperature is10 ℃; standing time is 5 days, and camphorsulfonic acid is vacuum dried. Utilizing sopropyl alcohol as solvent, camphor sulfonate is obtained by neutralization of camphorsulfonic acid and a resolving agent made by alcohol amine; camphorsulfonic acid is obtained by purification.
Preparation principle
Figure 2: Preparation principle

Resolution

Kinetic resolution is the selective chiral reduction of racemic camphor, so that one of the enantiomers of racemates is selectively reducted, leaving the required isomers, and then purifying. It is also possible to add optically active amino acids, phenylglycine, phenylalanine, hydroxyphenylglycine, o-chlorophenylglycine and resolving agents of its derivatives. Subjecting racemic camphorsulfonic acid to salting treatment, separating the left and right camphorsulfonic acid ammonium salt solution by chromatography, film evaporation, crystallization and filtration; drying to get white crystals, the left and right handed camphorsulfonic acid is made.

Uses

Pharmaceutical intermediates, optical split agent. Camphorsulfonic acid is an important organic synthesis intermediates, optical resolving agent. Due to its optical rotation, it is industrially applicable be the optical isomers for racemisation, and is also widely used as pharmaceutical intermediates such as for the production of intestinal disorder inhibitors, HIV improving agents and the like. Left and right handed camphorsulfonic acid is an important resolving agent for optically active amino acids, such as camphorsulfonic acid—a chiral ion-pairing reagent. It separates 5 substances—phenylpropanolamine, which has receptor-blocking action and cardiac inhibition and local anesthetic action effects; metoprolol, propranolol, epinephrine, salbutamol and atenolol.
Camphor sulfonate made by camphorsulfonic acid for salting or other synthetic routes also has a wide range of uses. For example, camphor sulfonate is a veterinary central stimulant, which can stimulate the respiratory center and cause respiratory excitement, ; it is used for the treatment respiratory and circulatory acute disorders, resisting central nervous system poisoning; camphor ammonium sulfonate acts as a chiral ion pair reagent added to the mobile phase to separate the aromatic alcohol amine drug enantiomers.
Camphor sulfonate
Figure 3: Camphor sulfonate

Market

The domestic demand for camphorsulfonic acid is high; camphorsulfonic acid is basically dependent on imports, and the price of it is also very expensive, especially for L-camphorsulfonic acid.

References

[1] KE Chunlan, LIU Xiaohong, XU Chunxiao etc. Synthesis and Resolution of Camphor Sulfonic Acid [J]. Journal of Nanchang University Engineering, 2010, 32 (4): 381-384.
[2] KE Chunlan, LIU Xiaohong, XU Chunxiao etc. Synthesis and latest application of chiral camphorsulfonic acid and its salts [J] .Jiangxi Chemical Industry, 2010 (2): 1-4.

Chemical Properties

DL-10-CAMPHORSULFONIC ACID is white to off-white powder

DL-10-CAMPHORSULFONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products


DL-10-CAMPHORSULFONIC ACID Suppliers

Global( 228)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4660 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8409 58
Wuhan Kai Lun new material Chemical Co Ltd 025-87787262;15071332665
025-87787262 wshun@51chemall.com China 499 58
Changzhou Carman Chemical Co., ltd 18151214939/ 15061933924
jane@carmanchem.com China 316 58
Hebei zeshuo pharmaceutical technology co. LTD 13021800888
export@zeshuobiotec.com China 11 58

View Lastest Price from DL-10-CAMPHORSULFONIC ACID manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-26 DL-Camphorsulfonic Acid
5872-08-2
US $100.00-90.00 / KG 1KG 99% Customized career henan chemical co

DL-10-CAMPHORSULFONIC ACID Spectrum


5872-08-2(DL-10-CAMPHORSULFONIC ACID)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved