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PENTAGASTRIN

PENTAGASTRIN Structure
PENTAGASTRIN structure
CAS No.
5534-95-2
Chemical Name:
PENTAGASTRIN
Synonyms
GRP;ay6608;ici50123;petavlon;peptavlon;petogasrin;lanineamide;PENTAGASTRIN;Pehtagastrin;gastrodiagnost
CBNumber:
CB4412263
Molecular Formula:
C37H49N7O9S
Molecular Weight:
767.9
MDL Number:
MFCD00076515
MOL File:
5534-95-2.mol
MSDS File:
SDS
Last updated:2024-04-12 23:00:59
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PENTAGASTRIN Properties

Melting point 229-230° (dec)
alpha D22 -28.8 ±0.5° (DMF)
Boiling point 1196.6±65.0 °C(Predicted)
Density 1.303±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).
form powder
pka 4.19±0.10(Predicted)
Sequence N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2
InChIKey NEYNJQRKHLUJRU-DZUOILHNSA-N
FDA UNII EF0NX91490
ATC code V04CG04

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Hazard Codes  T
Risk Statements  61-36/38-20/21
Safety Statements  53-45-36/37/39-22
WGK Germany  1
RTECS  AY2970000
NFPA 704
0
3 0

PENTAGASTRIN price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich BP278 Pentagastrin British Pharmacopoeia (BP) Reference Standard 5534-95-2 5MG $266 2024-03-01 Buy
Sigma-Aldrich B1636 Pentagastrin ≥95% (HPLC), powder 5534-95-2 25mg $266 2024-03-01 Buy
Sigma-Aldrich B1636 Pentagastrin ≥95% (HPLC), powder 5534-95-2 100mg $864 2024-03-01 Buy
Cayman Chemical 28546 Pentagastrin 5534-95-2 10mg $73 2024-03-01 Buy
Cayman Chemical 28546 Pentagastrin 5534-95-2 100mg $431 2024-03-01 Buy
Product number Packaging Price Buy
BP278 5MG $266 Buy
B1636 25mg $266 Buy
B1636 100mg $864 Buy
28546 10mg $73 Buy
28546 100mg $431 Buy

PENTAGASTRIN Chemical Properties,Uses,Production

Description

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

Chemical Properties

A white or almost white powder.

Originator

Peptavlon,I.C.I. ,UK,1967

Uses

anesthetic (local)

Uses

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Uses

diagnostic agent for gastric secretion disorders

Definition

ChEBI: Pentagastrin is an organic molecular entity.

Manufacturing Process

A solution of 3.55 parts of L-tryptophanyl-L-methionyl-L-aspartyl-Lphenylalanine amide trifluoroacetate in 30 parts of dimethylformamide is cooled to 0°C, and 1.01 parts of triethylamine are added. The mixture is stirred while 1.84 parts of N-tert-butyloxycarbonyl-β-alanine 2,4,5trichlorophenyI ester are added at 0°C. The reaction mixture is kept at 0°C for 48 hours and then at 20°-23°C for 24 hours. The mixture is added to a mixture of 100 parts of ice-water, 0.37 part of concentrated hydrochloric acid (SG 1.18), 1.2 parts of acetic acid and 20 parts of ethyl acetate. The mixture is stirred for 15 minutes at 0°-10°C and is then filtered. The solid residue is washed with water and then with ethyl acetate, and is dried at 40°-50°C under reduced pressure. There is thus obtained N-tert-butyloxycarbonyl-βalanyl-L-tryptophanyl-L-methionyl-L-aspartyl-L-phenylalanine amide, MP 213°C with de composition.

brand name

Peptavlon (Wyeth).

Therapeutic Function

Gastrosecretory hormone

General Description

Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.
Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.

Biochem/physiol Actions

CCKB agonist that stimulates gastric acid secretion; anxiogenic.Pentagastrin is an agonist of the cholecystokinin-2 (CCK2) receptor. It helps to increase the excitability of neurons in the basolateral amygdala through the activation of a non-specific cation channel.

PENTAGASTRIN Preparation Products And Raw materials

Raw materials

β-Alanine N-[(tert-Butoxy)carbonyl]-D-tryptophan Protective agent Propionamide L-ASPARTIC ACID

Preparation Products

PENTAGASTRIN Suppliers

Global( 167)Suppliers
Supplier Tel Email Country ProdList Advantage
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Shanghai Getian Industrial Co., LTD 		+86-15373193816 +86-15373193816 mike@ge-tian.com China 272 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Rixing Chemical CO.,LTD 		+86-13237129059 -13237129059 sales@rixingchemi.com CHINA 229 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Beijing Yibai Biotechnology Co., Ltd 		0086-182-6772-3597 sales04@yibaibiotech.com CHINA 419 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671 sales@tnjchem.com China 34572 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9358 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
Supplier Advantage
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Shanghai Getian Industrial Co., LTD 		58
Hangzhou FandaChem Co.,Ltd. 		55
Rixing Chemical CO.,LTD 		55
career henan chemical co 		58
Beijing Yibai Biotechnology Co., Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58

Related articles

  • Mechanism of action of Pentagastrin
  • Pentagastrin is a gastrin-like molecule used as a diagnostic aid for the evaluation of gastric acid secretory function, gastri....
  • May 6，2022

View Lastest Price from PENTAGASTRIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PENTAGASTRIN pictures 2024-04-12 PENTAGASTRIN
5534-95-2
 US $29.00 / box 1box 99% 20000 Shanghai Getian Industrial Co., LTD
Pentagastrin pictures 2024-01-02 Pentagastrin
5534-95-2
 US $75.00-750.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
Pentagastrin pictures 2023-05-27 Pentagastrin
5534-95-2
 US $45.00 / kg 1kg 99% 20tons Henan Bao Enluo International TradeCo.，LTD
  • PENTAGASTRIN pictures
  • PENTAGASTRIN
    5534-95-2
  • US $29.00 / box
  • 99%
  • Shanghai Getian Industrial Co., LTD
  • Pentagastrin pictures
  • Pentagastrin
    5534-95-2
  • US $75.00-750.00 / kg
  • 0.99
  • Zibo Hangyu Biotechnology Development Co., Ltd
  • Pentagastrin pictures
  • Pentagastrin
    5534-95-2
  • US $45.00 / kg
  • 99%
  • Henan Bao Enluo International TradeCo.，LTD

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T-BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2 aspartyl]-l-phenylalaninamide ay6608 boc-beta-ala-try-met-asp-phe(nh2) gastrodiagnost ici50123 lanineamide l-methionyl-l-alpha-aspartyl- l-n-tert-butyleste n-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-l-tryptophyl-l-phenylalaninamid petogasrin -tert-butylester ylpropionamido]-4-(methylthio)butyramido]succinamicacidn-tert-butylester n-t-boc-β-ala-trp-met-asp-phe amide N-T-boc-B-ala-trp-met-asp-phe amide PENTAGASTRIN (ICI 50123) SYNTHETIC >99% BOC-β-Ala-Trp-Met-Asp-Phe-NH2 N-(1,1-Dimethylethoxy)carbonyl-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2 N-Boc-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2 AY 6608, ICI 50123, NSC 367746, Boc-(b-Ala13)-Gastrin (13-17), Boc-b-Ala-CCK-4 Boc-b-Ala-Trp-Met-Asp-Phe-NH2 n-(alpha-carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3- n-[n-[n-[n-(n-tert-butoxycarbonyl-beta-alanyl)-l-tryptophanyl]-l-methionyl]-l- n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-alaninamid n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-l-alaninamiden n-t-butyloxycarbonyl-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartyl-l-phenyla peptavlon petavlon Boc-(β-Ala13)-Gastrin (13-17) GRP GASTRIN RELEASING PEPTIDE BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2 PENTAGASTRIN N-T-BOC-BETA-ALA-TRP-MET-ASP-PHE AMIDE Acetyl-L-glutamic acid &gamma Z-N-methyl-L-glutamic acid &gamma N-(Benzyloxycarbonyl)-L-glutamic Acid &alpha Fmoc-L-alpha-aminoadipic acid &delta Fmoc-N-methyl-L-glutamic acid &gamma Methotrexate &alpha 3-7-Cholecystokinin-7(swine), 3-[N-[(1,1-dimethylethoxy)carbonyl]-b-alanine]- (9CI) L-Glutamic Acid &alpha DL-Glutamic acid &gamma N-tert-Butyloxycarbonyl-L-aspartic Acid &beta Pentagastrin, ≥95%(HPLC) Z-L-beta-Glutamic acid &gamma Fmoc-L-aspartic Acid &beta Pehtagastrin L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl- PENTAGASTRIN USP/EP/BP Boc-(β-Ala13)-Gastrin (13-17) 5534-95-2 C37H49N7O9S C37H50N7O9S Gastrointestinal Products Cholecystokinins Peptides Amino Acids and Peptides