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Calcipotriene

Calcipotriene
Calcipotriene structure
CAS No.
112965-21-6
Chemical Name:
Calcipotriene
Synonyms
mc903;dovonex;Daivonex;Daivobet;Calciptriol;Calcipotriene;Calcipotriene-d4;CALCIPOTRIOL - EP;5z,7e,22e,24s)--bet;Calcipotriol hydrate
CBNumber:
CB4412713
Molecular Formula:
C27H40O3
Formula Weight:
412.6
MOL File:
112965-21-6.mol

Calcipotriene Properties

Melting point:
166-168°C
Boiling point:
582.0±50.0 °C(Predicted)
Density 
1.12±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
solubility 
DMSO: soluble15mg/mL, clear
pka
14.29±0.20(Predicted)
form 
powder
InChIKey
LWQQLNNNIPYSNX-HCHVWAPNSA-N
CAS DataBase Reference
112965-21-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2906195000

Calcipotriene price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4369 Calcipotriol hydrate ≥98% (HPLC) 112965-21-6 10mg $185 2018-11-13 Buy
Sigma-Aldrich 1086141 Calcipotriol hydrate 112965-21-6 200mg $2219.7 2019-12-02 Buy
Sigma-Aldrich C4369 Calcipotriol hydrate ≥98% (HPLC) 112965-21-6 50mg $708 2018-11-13 Buy

Calcipotriene Chemical Properties,Uses,Production

Description

Calcipotriol is a topical vitaminD3 derivative effective in the treatment of psoriasis vulgaris. The drug acts by binding to vitamin D3 receptors in the skin keratinocytes, producing an elevation in cell differentiation and a reduction in cell proliferation. Although its efficacy is comparable to calcitriol, calcipotriol exhibits at least 100 times less effect on calcium metabolism in rats.

Chemical Properties

White Crystalline Solid

Originator

Leo Denmark (Denmark)

Uses

An antipsoriatic. A vitamin D3 analogue with low calcemic activity

Uses

antipsoriatic;viamin D receptor (VDR) affinity

Uses

A labelled antipsoriatic. A vitamin D3 analogue with low calcemic activity.

Indications

Calcipotriene (Dovonex), a synthetic vitamin D3 derivative, is indicated for the treatment of moderate plaque psoriasis. Its mechanism of action is unknown, although it competes for calcitriol receptors on keratinocytes and normalizes differentiation. It also has a variety of immunomodulatory effects in the skin. Although the drug can cause local irritation, the most serious toxicities are hypercalciuria and hypercalcemia, which are usually reversible.

brand name

Dovonex (Leo);Daivonex.

Biological Activity

Vitamin D 3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Calcipotriene Preparation Products And Raw materials

Raw materials

Preparation Products


Calcipotriene Suppliers

Global( 137)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19927 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21829 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
sales@zetchem.com CHINA 2886 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58

View Lastest Price from Calcipotriene manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 Calcipotriene
112965-21-6
US $2.00 / kg 1kg 99% ask career henan chemical co

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