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Bupivacaine

Bupivacaine
Bupivacaine structure
CAS No.
2180-92-9
Chemical Name:
Bupivacaine
Synonyms
LAC-43;Anekain;MARCAINE;win11318;WIN 11318;BUPIVACAINE;Carbostesin;DL-Bupivacaine;BUPIVACAINE BASE;Bupivacaine (USP)
CBNumber:
CB4413068
Molecular Formula:
C18H28N2O
Formula Weight:
288.43
MOL File:
2180-92-9.mol

Bupivacaine Properties

Melting point:
107.5-108°
Boiling point:
430.65°C (rough estimate)
Density 
1.0238 (rough estimate)
refractive index 
1.5700 (estimate)
pka
8.09; also reported as 8.17(at 25℃)
Water Solubility 
101.5mg/L(25 ºC)
CAS DataBase Reference
2180-92-9(CAS DataBase Reference)
NIST Chemistry Reference
2-Piperidinecarboxamide, 1-butyl-n-(2,6-dimethylphenyl)-(2180-92-9)
EPA Substance Registry System
2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)- (2180-92-9)
SAFETY
  • Risk and Safety Statements
Hazard Codes  T+
Risk Statements  26/27/28-38-41
Safety Statements  22-26-36/37/39-45
RIDADR  2811

Bupivacaine Chemical Properties,Uses,Production

Uses

Anesthetic (local).

brand name

Marcaine (Hospira); Sensorcaine (AstraZeneca).

General Description

Bupivacaine was synthesized simultaneously with mepivacainein 1957 but was at first overlooked because of the increasedtoxicity compared with mepivacaine. When themethyl on the cyclic amine of mepivacaine is exchanged fora butyl group the lipophilicity, potency and the duration ofaction all increase. Literature reports of cardiovascular toxicity,including severe hypotension and bradycardia, areabundant in the literature.91 Bupivacaine is highly bound toplasma proteins (95%), and thus the free concentration mayremain low until all of the protein binding sites are occupied.After that point, the plasma levels of bupivacaine rise rapidlyand patients may progress to overt cardiac toxicity withoutever showing signs of CNS toxicity. The cardiotoxicity ofbupivacaine is a result of its affinity to cardiac tissues and itsability to depress electrical conduction and predispose theheart to reentry types of arrhythmias. The cardiotoxicity ofbupivacaine was found to be significantly more prominentwith the “R” isomer, or the racemic mixture, thus the “S”stereoisomer is now on the market as levobupivacaine.

Bupivacaine Preparation Products And Raw materials

Raw materials

Preparation Products


Bupivacaine Suppliers

Global( 131)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 302 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21791 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 569 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1012 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 295 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2370 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1278 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23048 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35438 58

View Lastest Price from Bupivacaine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-12-18 Bupivacaine
2180-92-9
US $1.00 / g 1g 99% g/kg/T Career Henan Chemical Co
2019-07-03 Bupivacaine
2180-92-9
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-10-12 bupivacaine
2810-92-9
US $30.00 / KG 1KG 99.8% 10tons Hebei shuoxi biotechnology co. LTD

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