AMCINONIDE
- CAS No.
- 51022-69-6
- Chemical Name:
- AMCINONIDE
- Synonyms
- Amicla;Visderm;cl-34699;Amciderm;Penticort;Amcinonid;cyclocort;Amcinopol;AMCINONIDE;Ann's sinai
- CBNumber:
- CB4419202
- Molecular Formula:
- C28H35FO7
- Molecular Weight:
- 502.57
- MDL Number:
- MFCD00213379
- MOL File:
- 51022-69-6.mol
- MSDS File:
- SDS
| Melting point | >216°C (dec.) |
|---|---|
| Boiling point | 635.9°C (rough estimate) |
| Density | 1.33±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5860 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile (Slightly), Dichlomethane (Slightly), Dioxane (Slightly), Methanol |
| pka | 13.09±0.70(Predicted) |
| color | White to Off-White |
| FDA UNII | 423W026MA9 |
| ATC code | D07AC11 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361-H373 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P260-P314-P501 |
| WGK Germany | 2 |
| RTECS | TU3682500 |
| HS Code | 2937220000 |
AMCINONIDE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1019202 | Amcinonide United States Pharmacopeia (USP) Reference Standard | 51022-69-6 | 200mg | $381 | 2024-03-01 | Buy |
| Cayman Chemical | 23903 | Amcinonide ≥98% | 51022-69-6 | 50mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 23903 | Amcinonide ≥98% | 51022-69-6 | 100mg | $60 | 2024-03-01 | Buy |
| Cayman Chemical | 23903 | Amcinonide ≥98% | 51022-69-6 | 250mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 23903 | Amcinonide ≥98% | 51022-69-6 | 500mg | $213 | 2024-03-01 | Buy |
AMCINONIDE Chemical Properties,Uses,Production
Originator
Cyclocort,Lederle,US,1979
Uses
antiinflammatory
Uses
Glucocorticoid.
Definition
ChEBI: Amcinonide is a corticosteroid, an 11beta-hydroxy steroid, a fluorinated steroid, a 20-oxo steroid, an acetate ester, a spiroketal and a 3-oxo-Delta(1),Delta(4)-steroid. It has a role as an anti-inflammatory drug. It derives from a hydride of a pregnane.
Manufacturing Process
An 11.1 g (24.1 mmol) portion of the compound 16α,17α- cyclopentylidenedioxy-9α-fluoro-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione is placed in a 250 ml round-bottom flask. A 100 ml portion of pyridine is added and the mixture is stirred to a complete solution. A 5.5 ml (54.6 mmol) portion of acetic anhydride is added dropwise and the mixture is stirred for 2% hours. An 11 ml portion of methanol is added and the mixture is stirred an additional hour. This mixture is concentrated under reduced pressure to about 10 to 15 ml and then poured slowly into a mixture of ice, water and dilute hydrochloric acid. This mixture is stirred and the solid which forms is collected by filtration, washed with water to a neutral pH and air dried yielding 11.5 g. This solid is taken up in hot acetone, treated with activated charcoal and filtered while hot through diatomaceous earth. The filtrate is concentrated on a steam bath while adding n-hexane to the point of incipient crystallization. This mixture is allowed to cool to room temperature. The solid which forms is collected by filtration, washed with acetone-n-hexane (1:14) and air dried yielding 7.0 g of the desired product.
brand name
Cyclocort (Astellas.
Therapeutic Function
Topical corticosteroid, Antiinflammatory
General Description
Amcinonide, 21-(acetyloxy)-16α,17-[cyclopentylidenebis(oxy)]-9-fluoro-11β-hydroxypregna-1,4-diene-3,20-dione (Cyclocort).
AMCINONIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 | kyra@quanjinci.com | China | 1532 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
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