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ANTI-ERBB2

ANTI-ERBB2 Structure
ANTI-ERBB2 structure
CAS No.
Chemical Name:
ANTI-ERBB2
Synonyms
ANTI-NEU;ANTI-HER2;Anti-NANH;ANTI-ERBB2;Anti-SIAL1;ANTI-C-NEU(AB-1);ANTI-C-NEU(AB-5);ANTI-NEU (AB-4), HUMAN;ANTI-NEU (AB-6), HUMAN;ANTI-NEU (AB-7), HUMAN
CBNumber:
CB4427362
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD00239653
MOL File:
Mol file
Last updated:2023-04-23 13:52:06
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ANTI-ERBB2 Properties

storage temp. -20°C
form buffered aqueous solution

ANTI-ERBB2 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E2777 Monoclonal Anti-c-erbB-2 antibody produced in mouse ~2?mg/mL, clone HER2-96, purified immunoglobulin, buffered aqueous solution 0.2mL $635 2024-03-01 Buy
Product number Packaging Price Buy
E2777 0.2mL $635 Buy

ANTI-ERBB2 Chemical Properties,Uses,Production

Uses

Monoclonal Anti-c-erbB-2 antibody produced in mouse has been used in :

  • enzyme linked immunosorbent assay (ELISA)
  • immunoprecipitation
  • immunohistochemistry
  • studies on receptor internalization, phosphorylation, ligand binding and tumor growth inhibition

General Description

Monoclonal Anti-c-erbB-2 (HER-2, Neu) (mouse IgG1 isotype) is derived from the (human epidermal growth factor receptor 2) HER2-96 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with a purified extracellular domain of human erbB-2, from transfected cells. The human erbB-2 oncogen (also known as HER2, HER-2 or neu) encodes a transmembrane growth factor orphan receptor with a M.W. of 185 kDa (p185). The complete protein consists of an internal cytoplasmic structure with tyrosine kinase activity, a short hydrophobic transmembrane section and an extracellular ligand-binding domain (ECD).

Biochem/physiol Actions

Erb-b2 receptor tyrosine kinase 2 (ErbB-2) has a pivotal role in signal transduction, where it can stimulate the signal even in the absence of ligand by forming heterodimers with erbB-1/EGF-R, erbB-3, and erbB-4 and hence can modifies ligand affinity. Thus, erbB-2 alters the intracellular responses elicited by EGF and NDF. This control is due to the fact that erbB-2, when in complex with another erbB family receptor, decelerates the rate of ligand dissociation. Therefore, erbB-2 may act as a signalling subunit for other receptors rather than a true growth factor receptor. Because overexpression of the erbB-2 proto-oncogene is frequently associated with an aggressive clinical course of certain human adenocarcinomas, the encoded protein is an attractive target for immunotherapy. Indeed, antibodies to erbB-2 were found to block the crosstalk with growth factor receptors. In addition, receptor overexpression is considered a predictor of poor survival and short time of relapse.

ANTI-ERBB2 Preparation Products And Raw materials

Raw materials

Preparation Products

ANTI-ERBB2 Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
ANTI-HUMAN EPIDERMAL GROWTH FACTOR ANTI-HUMAN EPIDERMAL GROWTH FACTOR (AB-4), HUMAN ANTI-HUMAN EPIDERMAL GROWTH FACTOR (AB-6), HUMAN ANTI-HUMAN EPIDERMAL GROWTH FACTOR (AB-6) MOUSE MAB ANTI-HUMAN EPIDERMAL GROWTH FACTOR (AB-7), HUMAN ANTI-ERBB2 ANTI-ERBB2 (AB-4), HUMAN ANTI-C-ERBB2/C-NEU (AB-1), HUMAN ANTI-C-ERBB2/C-NEU (AB-4), HUMAN ANTI-C-ERBB2/C-NEU (AB-4) MOUSE MAB ANTI-C-ERBB2/C-NEU (AB-5), HUMAN ANTI-C-ERBB2/C-NEU (AB-5) MOUSE MAB ANTI-C-ERBB2/C-NEU (AB-6), HUMAN ANTI-C-ERBB2/C-NEU (AB-6) MOUSE MAB ANTI-C-ERBB2/C-NEU (AB-7), HUMAN ANTI-C-NEU(AB-1) ANTI-C-NEU (AB-1), HUMAN ANTI-C-NEU (AB-4), HUMAN ANTI-C-NEU (AB-4) MOUSE MAB ANTI-C-NEU(AB-5) Monoclonal Anti-NEU1 antibody produced in mouse Monoclonal Anti-c-erbB-2 antibody produced in mouse Anti-Sialidase 1 (lysosomal sialidase) ANTI-C-ERBB2/C-NEU (AB-1) ANTI-C-ERBB2/C-NEU (AB-1) (866-880) RABBIT PAB ANTI-ERBB2 (AB-4) MOUSE MAB ANTI-ERBB2 (AB-5), HUMAN ANTI-ERBB2 (AB-5) MOUSE MAB ANTI-ERBB2 (AB-6), HUMAN ANTI-ERBB2 (AB-6) MOUSE MAB ANTI-ERBB2 (AB-7), HUMAN ANTI-ERYTHROBLASTOSIS VIRUS (AB-4), HUMAN ANTI-ERYTHROBLASTOSIS VIRUS (AB-4) MOUSE MAB ANTI-ERYTHROBLASTOSIS VIRUS (AB-5), HUMAN ANTI-ERYTHROBLASTOSIS VIRUS (AB-5) MOUSE MAB ANTI-ERYTHROBLASTOSIS VIRUS (AB-6), HUMAN ANTI-ERYTHROBLASTOSIS VIRUS (AB-6) MOUSE MAB ANTI-ERYTHROBLASTOSIS VIRUS (AB-7), HUMAN ANTI-ERYTHROBLASTOSIS VIRUS (AB-1), HUMAN ANTI-ERYTHROBLASTOSIS VIRUS ANTI-ERYTHROBLASTOSIS VIRUS (AB-1) (866-880) RABBIT PAB ANTI-HER2 ANTI-HER2 (AB-1) (866-880) RABBIT PAB ANTI-HER2 (AB-1), HUMAN ANTI-HER2 (AB-4), HUMAN ANTI-HER2 (AB-4) MOUSE MAB ANTI-HER2 (AB-5), HUMAN ANTI-HER2 (AB-5) MOUSE MAB ANTI-HER2 (AB-6), HUMAN ANTI-HER2 (AB-6) MOUSE MAB ANTI-HER2 (AB-7), HUMAN ANTI-NEU ANTI-NEU (AB-4), HUMAN ANTI-NEU (AB-4) MOUSE MAB ANTI-NEU (AB-6), HUMAN ANTI-NEU (AB-6) MOUSE MAB ANTI-NEU (AB-7), HUMAN C-ERBB2/C-NEU (AB-1) POLYCLONAL ANTIBODY POLYCLONAL ANTIBODY