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FTI-276

FTI-276 Structure
FTI-276 structure
CAS No.
170006-72-1
Chemical Name:
FTI-276
Synonyms
FTI-276;ZIXDDEATQSBHHL-BEFAXECRSA-N;FTI-276 trifluoroacetate salt;N-[2-PHENYL-4-N[2(R)-AMINO-3-MERCAPTOPROPYLAMINO BENZOYL]-METHIONINE, TFA;L-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-;N-[4-[2-(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL]METHIONINE TRIFLUOROACETATE SALT
CBNumber:
CB4442484
Molecular Formula:
C21H27N3O3S2
Molecular Weight:
433.59
MDL Number:
MFCD03700738
MOL File:
Mol file
Last updated:2023-05-18 11:31:03
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FTI-276 Properties

Boiling point 715.6±60.0 °C(Predicted)
Density 1.272±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility H2O: >5 mg/mL, soluble
form solid
pka 3.54±0.10(Predicted)
color off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

FTI-276 price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 344550 FTI-276 A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC?? = 500 pM). 250μG $245 2024-03-01 Buy
Usbiological 255340 FTI 276 170006-72-1 1mg $389 2021-12-16 Buy
ChemScene CS-0009428 FTI276 170006-72-1 5mg $400 2021-12-16 Buy
American Custom Chemicals Corporation HCH0066839 FTI-276 TRIFLUOROACETATE SALT 95.00% 170006-72-1 1MG $676.71 2021-12-16 Buy
ChemScene CS-0009428 FTI276 170006-72-1 10mg $680 2021-12-16 Buy
Product number Packaging Price Buy
344550 250μG $245 Buy
255340 1mg $389 Buy
CS-0009428 5mg $400 Buy
HCH0066839 1MG $676.71 Buy
CS-0009428 10mg $680 Buy

FTI-276 Chemical Properties,Uses,Production

Uses

N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine Trifluoroacetate Salt is a useful intermediate.

Definition

ChEBI: (2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-phenylphenyl]-oxomethyl]amino]-4-(methylthio)butanoic acid is a methionine derivative.

Biochem/physiol Actions

FTI-276 is a highly potent RasCAAX peptidomimetic. FTI-276 antagonizes both H and K-Ras oncogenic signaling. It is an inhibitor of farnesyltransferase (Ftase) in vitro with an IC50 of 500 pM and is an anti-cancer agent.

FTI-276 Preparation Products And Raw materials

Raw materials

Preparation Products

FTI-276 Suppliers

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49999 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
United States Biological -- sales@advtechind.com United States 6106 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Sigma-Aldrich 80
EMMX Biotechnology LLC 60
TargetMol Chemicals Inc. 58
United States Biological 58
N-[4-[2-(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL]METHIONINE TRIFLUOROACETATE SALT N-[2-PHENYL-4-N[2(R)-AMINO-3-MERCAPTOPROPYLAMINO BENZOYL]-METHIONINE, TFA FTI-276 FTI-276 trifluoroacetate salt ZIXDDEATQSBHHL-BEFAXECRSA-N L-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]- 170006-72-1 C21H27N3O3S2C2HF3O2 C23H28F3N3O5S2