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18-Crown-6

18-Crown-6 Structure
18-Crown-6 structure
CAS No.
17455-13-9
Chemical Name:
18-Crown-6
Synonyms
1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE;8-Crown-6;HEXAOXACYCLOOCTADECANE;18-CROWN 6-ETHER;Ethylene oxide cyclic hexamer;18-Crown ether-6;18-c-6;18-CROWN-6;NSC 159836;18-Crown-6 99%
CBNumber:
CB4445218
Molecular Formula:
C12H24O6
Molecular Weight:
264.32
MDL Number:
MFCD00005113
MOL File:
17455-13-9.mol
MSDS File:
SDS
Last updated:2025-09-26 17:40:57
Product description Number Pack Size Price
Crown ether/18-Crown-6 for synthesis 8.11684 2g $26.8
Crown ether/18-Crown-6 for synthesis 8.11684 5G $34.2
Crown ether/18-Crown-6 for synthesis 8.11684 25g $157
18-Crown-6 purum, ≥99.0% (GC) 28125 5g $47.9
18-Crown-6 99% 186651 5G $116
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18-Crown-6 Properties

Melting point 42-45 °C(lit.)
Boiling point 116°C 0,2mm
Density 1,175 g/cm3
refractive index 1.4580 (estimate)
Flash point >230 °F
storage temp. Store below +30°C.
solubility Chloroform (Slightly), Methanol (Very Slightly)
form Crystals or Crystalline Mass or Liquid
color White or clear colorless
Water Solubility SOLUBLE
Sensitive Hygroscopic
Merck 14,2602
BRN 1619616
Stability Stable. Incompatible with strong acids, strong oxidizing agents.
InChIKey XEZNGIUYQVAUSS-UHFFFAOYSA-N
CAS DataBase Reference 17455-13-9(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE
FDA UNII 63J177NC5B
NIST Chemistry Reference 1,4,7,10,13,16-Hexaoxacyclooctadecane(17455-13-9)
EPA Substance Registry System 1,4,7,10,13,16-Hexaoxacyclooctadecane (17455-13-9)
UNSPSC Code 12352005
NACRES NB.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-36-20/22-20/21/22
Safety Statements  26-36-39
RIDADR  2811
WGK Germany  3
RTECS  MP4500000
F  10
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29329995
Toxicity LD50 orally in Rabbit: 525 mg/kg LD50 dermal Rabbit 3888 mg/kg
NFPA 704
1
2 0

18-Crown-6 price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.11684 Crown ether/18-Crown-6 for synthesis 17455-13-9 2g $26.8 2025-07-31 Buy
Sigma-Aldrich 8.11684 Crown ether/18-Crown-6 for synthesis 17455-13-9 5G $34.2 2025-07-31 Buy
Sigma-Aldrich 8.11684 Crown ether/18-Crown-6 for synthesis 17455-13-9 25g $157 2025-07-31 Buy
Sigma-Aldrich 28125 18-Crown-6 purum, ≥99.0% (GC) 17455-13-9 5g $47.9 2025-07-31 Buy
Sigma-Aldrich 186651 18-Crown-6 99% 17455-13-9 5G $116 2025-07-31 Buy
Product number Packaging Price Buy
8.11684 2g $26.8 Buy
8.11684 5G $34.2 Buy
8.11684 25g $157 Buy
28125 5g $47.9 Buy
186651 5G $116 Buy

18-Crown-6 Chemical Properties,Uses,Production

Chemical Properties

18-Crown-6 is a slightly yellow solid, it has a high affinity for the hydronium ion H3O+, as it can fit inside the crown ether. Thus, reaction of 18-crown-6 with strong acids gives the cation [H3O·18-crown-6]+.

Uses

18-Crown-6 is used as an efficient phase transfer catalyst and as a complexing agent with a variety of small cation. It is involved in the synthesis of diaryl ethers, diaryl thioethers, and diarylamines mediated by potassium fluoride-alumina and 18-crown-6. It facilitates the solubility of potassium permanganate in benzene, which is used for oxidizing the organic compounds. It is used to accelerate various substitution reactions as well as enhances the power of nucleophiles such as potassium acetate. It is utilized in the alkylation reactions in the presence of potassium carbonate, N-alkylation of glutarimide and succinimide with dimethylcarbonate. The complex formed by its reaction with potassium cyanide acts as a catalyst in the cyanosilylation of aldehydes, ketones and quinines with trimethylsilyl cyanide (TMSCN).

Uses

A useful phase transfer catalyst.

Uses

18-Crown-6 may be used to catalyze the N-alkylation of heterocyclic compounds and allylation of functionalized aldehydes.

Definition

ChEBI: 18-crown-6 is a crown ether that is cyclooctadecane in which the carbon atoms at positions 1, 4, 7, 10, 13 and 16 have been replaced by oxygen atoms. It has a role as a phase-transfer catalyst. It is a crown ether and a saturated organic heteromonocyclic parent.

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 2445, 1974 DOI: 10.1021/jo00930a037

General Description

18-Crown-6 is the simplest crown ether that can be prepared by reacting triethylene glycol with triethylene glycol dichloride in the presence of potassium hydroxide as a base. 18-Crown-6 can solubilize metal salts, particularly potassium salts, in nonpolar and dipolar aprotic solvents. Thus, it is widely used as a phase transfer catalyst. It can also be used as a metal complexing agent to prepare a variety of molecular complexes.

Purification Methods

Recrystallise it from acetonitrile and dry it in a vacuum. Purify it also by precipitating the 18-crown-6/nitromethane 1:2 complex with Et2O/nitromethane (10:1 mixture). The complex is decomposed in vacuum whereby 18-crown-6 distils off under the reduced pressure. [Beilstein 19/12 V 601.]

18-Crown-6 synthesis

112-27-6
17455-13-9
Synthesis of 18-Crown-6 from Triethylene glycol

18-Crown-6 Preparation Products And Raw materials

Raw materials

Organic base GLOBULINS, CAT GAMMA Biochemistry Alkali Metals, plasma standard solution, Specpure, Ba,Be,Ca,Cs,K,Li,Mg,Na,Rb,Sr, 100μg/ml POTASSIUM CYANIDE
15-Crown-5

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Preparation Products

[(2-OXO-2H-CHROMEN-7-YL)OXY]ACETIC ACID 5-AMINOMETHYL-PYRROLIDIN-2-ONE 5-bromo-1H-indazole 3-AMINO-2-FLUORO-4-PICOLINE 1,2-EPOXYCYCLODODECANE
Cefpodoxime proxetil 4-AMINO-2,6-DIFLUOROPYRIMIDINE 1,1'-DIMETHYLFERROCENE N,N-Dimethylethylenediamine 2-(4-BROMOPHENYL)THIOPHENE
3-PHENOXYPHENYLACETONITRILE 2,4-DIAMINO-6-FLUOROPYRIMIDINE 2-AMINO-4,6-DIFLUOROPYRIMIDINE 1,3-THIAZOLIDIN-2-ONE N,N,N',N'-Tetraphenylbenzidine

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18-Crown-6 Suppliers

Global( 768)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Believe Chemical PTE.LTD 		+86-18553607090 +8618553607090 1093908296@qq.com China 1663 58
weifang runzhong fine chemical co., ltd
536-7868377 +8618653686003 sq@runzhongchem.com China 187 58
HANGZHOU LEAP CHEM CO., LTD.
+86-571-87711850 market18@leapchem.com China 43339 58
Suzhou Yangen Biotech Co.Ltd
+8615051547453 christina@yangenbiotech.com China 229 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8770 58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		+8613288715578 sales@sichuanzyyt.com China 12217 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5250 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20171 58
Supplier Advantage
Shandong Believe Chemical PTE.LTD 		58
weifang runzhong fine chemical co., ltd
58
HANGZHOU LEAP CHEM CO., LTD.
58
Suzhou Yangen Biotech Co.Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58

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View Lastest Price from 18-Crown-6 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
18-Crown-6 pictures 2025-11-14 18-Crown-6
17455-13-9
 0.99 RongNa Biotechnology Co.,Ltd
18-crown - 6 ether pictures 2025-11-14 18-crown - 6 ether
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 US $0.00 / PCS 1PCS 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
18-Crown-6 pictures 2025-11-14 18-Crown-6
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 US $0.00 / KG 1KG 99%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
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    17455-13-9
  • 0.99
  • RongNa Biotechnology Co.,Ltd
  • 18-Crown-6 pictures
  • 18-Crown-6
    17455-13-9
  • US $0.00 / KG
  • 99%min
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18-Crown-6 Spectrum

18-Crown-6(17455-13-9)MS18-Crown-6(17455-13-9)1HNMR18-Crown-6(17455-13-9)13CNMR18-Crown-6(17455-13-9)IR118-Crown-6(17455-13-9)IR218-Crown-6(17455-13-9)Raman18-Crown-6(17455-13-9)ESR

17455-13-9(18-Crown-6 )Related Search:

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4'' 4 (5 )-DI-TERT.BUTYLDICYCLOHEXANO-18-CROWN-6,MIXTUREOFISOMERS (+)-(18-CROWN-6)-2,3,11,12-TETRACARBOXYLIC ACID Dicyclohexano-18-crown-6 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE-2-METHANOL 4-ACRYLAMIDOBENZO-18-CROWN-6 98%
Isobutyl iodide 4',4''(5'')-di-tert-butyldibenzo-18-crown-6, mixed isomers,4,4'-Di-tert-butyldibenzo-18-crown-6 4-AMINOBENZO-18-CROWN-6 PURUM,97% 4-Nitrobenzo-18-crown-6,99% 4-VINYLBENZO-18-CROWN-6 97%
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DIBENZO-18-CROWN-6,Dibenzo-18-crown-6, 98+%

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18-CROWN-6 CROWN-18-5-ETHER CROWN ETHER/18-CROWN-6 AKOS BBS-00004361 CROWN ETHER/18-CROWN-6 FOR SYNTHESIS 18 and crown ether 18-Crown-6 >=99.0% 18-Crown-6 99% 18-Crown-6 puruM, >=99.0% (GC) 18 - the chaMpions league - 6 - ether 1,4,7,10,13,16-Hexaoxacyclooctadecane 99% 1,4,7,1,13,16-Hexaoxacyclooctadecane 18-CROWN-6, 99.5+% 18-CROWN-6(1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE) 18-Crown-6, 98+% 1,4,7,10,13,16-HEXOXA-CYCLO-OCTADECANE 18-Crown-6,99% 1,4,7,10,13,16-Hexanoxacyclooctadecane. 18-Crown-6-ether 99% 1,4,7,10,13,16-Hexaoxacyclooctadecane (18-Crown-6) 18-CROWN-6 99.8% Crown/18-crown-6 1,4,7,10,13,16-Hexaoxacyclooctadecane, Hexaoxacyclooctadecane 18-CROWN-6-ETHER pure NSC 159836 18-Crown-6/1,4,7,10,13,16-HexaoxacyclooCLadecane 18-Crown-6, 99% 25GR 18-Crown-6, 99% 5GR JACS-17455-13-9 18-Crown-6 solution 18-Crown-6, 99%, reagent grade 18-Crown 6-Ether > 18-Crown-6（1,4,7,10,13,17-Hexaoxacyclooctadecane）,>99% 18-Crown-6（1,4,7,10,13,18-Hexaoxacyclooctadecane）,>99% High quality 18-Crown-6 CAS 17455-13-9 Crown Ether 18-Crown 6-Ether, ≥ 98.0% 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE 18-CROWN 6-ETHER HEXAOXACYCLOOCTADECANE 8-Crown-6 18-Crown ether-6 Ethylene oxide cyclic hexamer N,N-Diethylformamide 617-84-5 18-Crown-8-Ether Octadecyl hexaether 18-Crown-6 1,4,7,10,13,16-Hexaoxacyclooctadecane (1,4,7,10,13,16-hexaoxacyclooctadecane) Crownwhitextl 18-Crown-6-ether 18-Crown-6-ether 98% For Synthesis 18-c-6 17455-13-9 7455-13-9 C12H24O6 Synthetic Reagents Trace Analysis Reagents General Use Macrocycles for Host-Guest Chemistry Crown Ethers Analytical Reagents Analytical Chromatography Product Catalog