10-Hydroxycamptothecin

10-Hydroxycamptothecin Properties

Melting point	265-270°C
Boiling point	820.7±65.0 °C(Predicted)
Density	1.60
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form	powder to crystal
pka	8.93±0.40(Predicted)
color	White to Yellow to Orange
InChIKey	HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference	19685-09-7(CAS DataBase Reference)
FDA UNII	9Z01632KRV

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H340

Precautionary statements

P202-P264-P270-P280-P301+P310-P405

Safety Statements

24/25

HS Code

29349990

NFPA 704

	0
2		0

10-Hydroxycamptothecin price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2491	Irinotecan Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	19685-09-7	25MG	$485	2024-03-01	Buy
Sigma-Aldrich	1347610	Irinotecan Related Compound A	19685-09-7	10mg	$1490	2024-03-01	Buy
TCI Chemical	H1463	10-Hydroxycamptothecin >98.0%(HPLC)	19685-09-7	1g	$231	2024-03-01	Buy
Cayman Chemical	14635	(S)-10-hydroxy-Camptothecin ≥98%	19685-09-7	25mg	$57	2024-03-01	Buy
Cayman Chemical	14635	(S)-10-hydroxy-Camptothecin ≥98%	19685-09-7	50mg	$107	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR2491	25MG	$485	Buy
1347610	10mg	$1490	Buy
H1463	1g	$231	Buy
14635	25mg	$57	Buy
14635	50mg	$107	Buy

10-Hydroxycamptothecin Chemical Properties,Uses,Production

Description

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G₂/M phase.

Chemical Properties

Yellow Solid

Uses

A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy

Definition

ChEBI: 10-Hydroxycamptothecin is a pyranoindolizinoquinoline.

in vitro

10-Hydroxycamptothecin inhibited the growth of BT-20 and MDA-231 cells with IC50 of 34.3nM and 7.27nM, respectively, which was more potent than camptothecin (CPT) with IC50>500nM. 10-Hydroxycamptothecin potently induces the formation of the pBR322 plasmid DNA cleavage complex mediated by human topoisomerase I with an EC50 of 0.35 μM, more than 50-fold more potent than CPT with an EC50 of 18.85 μM. 10-Hydroxycamptothecin treatment caused dose-dependent growth inhibition of human microvascular endothelial cells (HMECs) with IC50 of 0.31 μM and significantly inhibited HMEC migration with IC50 of 0.63 μM. Treatment of HMEC cells with 10-Hydroxycamptothecin also inhibited microtubule formation in a dose-dependent manner with IC50 of 0.96 μM. 10-Hydroxycamptothecin (5-20 nM) significantly inhibits the differentiation of Colo205 cells, arrests the cell cycle in G2 phase, and induces apoptosis through a caspase-3-dependent pathway.

in vivo

In the CAM model, 10-Hydroxycamptothecin treatment inhibited angiogenesis in a concentration-dependent manner, with 95% inhibition at 25 nM, more potent than suramin, which inhibited only 60% of angiogenesis at 125 nM. 10-Hydroxycamptothecin, administered orally at low doses of 2.5-7.5 mg/kg every two days, caused significant growth inhibition in Colo205 xenograft mice, but no acute toxicity. LD50: 104 mg/kg in mice (intraperitoneal injection).

IC 50

0.31 μm

References

[1] vladu b, woynarowski jm, manikumar g, wani mc, wall me, von hoff dd, wadkins rm. 7- and 10-substituted camptothecins: dependence of topoisomerase i-dna cleavable complex formation and stability on the 7- and 10-substituents. mol pharmacol. 2000 feb;57(2):243-51.
[2] xiao d, tan w, li m, ding j. antiangiogenic potential of 10-hydroxycamptothecin. life sci. 2001 aug 24;69(14):1619-28.
[3] ping yh, lee hc, lee jy, wu ph, ho lk, chi cw, lu mf, wang jj. anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. oncol rep. 2006 may;15(5):1273-9.

10-Hydroxycamptothecin synthesis

Synthesis of 10-Hydroxycamptothecin from (+)-Camptothecin

10-Hydroxycamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

TOPOTECANACETATE

10-Hydroxycamptothecin Suppliers

Global( 456)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2995	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Biochempartner	58
Chengdu Biopurify Phytochemicals Ltd.	58
Accela ChemBio Inc.	58
Xi'an Kono chem co., Ltd.,	58
Shaanxi Pioneer Biotech Co., Ltd .	58

View Lastest Price from 10-Hydroxycamptothecin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	Hydroxycamptothecin 19685-09-7	US $0.00-0.00 / g	1g	98%	2000	Changsha Staherb Natural Ingredients Co., Ltd.
2023-02-24	10-Hydroxycamptothecin 19685-09-7	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.
2023-02-13	10-Hydroxy Camptothecin 19685-09-7	US $100.00 / kg	1kg	99%	50MT	Hebei baicao biology science and technology co., ltd

Hydroxycamptothecin
19685-09-7
US $0.00-0.00 / g
98%
Changsha Staherb Natural Ingredients Co., Ltd.

10-Hydroxycamptothecin
19685-09-7
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

10-Hydroxy Camptothecin
19685-09-7
US $100.00 / kg
99%
Hebei baicao biology science and technology co., ltd

10-Hydroxycamptothecin Spectrum

10-Hydroxycamptothecin(19685-09-7)¹HNMR

19685-09-7(10-Hydroxycamptothecin)Related Search:

10-HYDROXYCAMPTOTHECIN 10-Nitrocamptothecin (+)-Camptothecin Irinotecan hydrochloride 7-Ethyl-10-hydroxycamptothecin

SN-38 GLUCURONIDE sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate Irinotecan 7,11-Diethyl-10-hydroxycaMptothecin Irinotecan Impurity 6

Irinotecan EP Impurity H 12-Hydroxy Irinotecan 7-Ethylcamptothecin Irinotecan EP Impurity K (Mixture of Diastereomers) Irinotecan IMpurity G

Irinotecan Impurity 5 RPR 121056 GURKHSYORGJETM-MGDILKBHSA-N

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Camptothecae Acuminatae extract hydrate,(s)-dihydroxy hydroxy-camptotheci Hydroxycamptothencine (20S)-10-HYDROXYCAMPTOTHECIN 98% (20S)-10-Hydroxycamptothecin HYDROCAMPTOTHECINE CAMPTOTHECIN, 10-HYDROXY(SH) HYDROXYCAMPTOTHECIN, 10-(P) 10-hydroxycamptothecin (TECANS) 10-HYDROCAMPTOTHECIN Ampule (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione NSC 107124 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,10-dihydroxy-, (4S)- (4S)-4,9-Dihydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)- (S)-10-Hydroxycamptothecin (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Irinotecan USP RC A CAMPTOTHECIN, 10-HYDROXY- CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA HYDROXYCAMPTOTHECIN, 10- (20S)-10-HYDROXYCAMPTOTHECIN (20S)-7-ETHYL-10-HYDROXYCAMPTOTHECIN (S)-10-HYDROXYCAMPTOTHECIN CaMptothecin IMpurity CaMptothecin 10-Hydroxy IMpurity 10-HydroxycaMptothecin, froM Taxus chinensis (s)-10-hydroxycamptothecinhydrate 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-1h-pyrano(3 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-dihydroxy-,hydrate,(s)-1h-pyrano(3 (4S)-4α-Ethyl-4,9-dihydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione (4S)-9-Hydroxy-4-hydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 10-Hydroxycamptothecin 10-Hydroxycamptothecine HYDROXYCAMPTOTHECIN, 10-(RG) 10-hydroxycamptothecin,HCPT (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione Irinotecan Related CoMpound A (+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione Irinotecan Related Compound A (10 mg) ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione) 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 10-HydroxycaMptothecin, HydroxycaMptothecine 10-Hydroxycamptothecin, 98%, from Taxus chinensis (Pilg.) Rehder Irinotecan Impurity 12 Irinotecan EP Impurity B 10-Hydroxycamptothecin 19685-09-7 (S)-4-ethyl-4,9-dihydroxy-1H-pyrano 10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY B) Fructus Camptothecae Hydroxycamptothecin 80-98% (S)-10-Hydroxycamptothecin,>98% (20S)-10-Hydroxycamptothecine Camptotheca acuminata fruit extract (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione 1-Hydroxy camptothecin 10 hydroxy CamptothecinQ: What is 10 hydroxy Camptothecin Q: What is the CAS Number of 10 hydroxy Camptothecin Q: What is the storage condition of 10 hydroxy Camptothecin Irinotecan Related Compound A ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3'',4'':6,7]indolizino[1,2-b]quino (1347610) (S)-10-HYDROXYCAMPTOTHECIN SN38