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1,4-Butanediol

CAS No.
110-63-4
Chemical Name:
1,4-Butanediol
Synonyms
BDO;Butylene glycol;Butanediol;BUTANE-1,4-DIOL;TETRAMETHYLENE GLYCOL;1,4-Butandiol;1,4-BD;sucolb;Diol 14B;4-Butanediol
CBNumber:
CB4452184
Molecular Formula:
C4H10O2
Molecular Weight:
90.12
MDL Number:
MFCD00002968
MOL File:
110-63-4.mol
MSDS File:
SDS
Last updated:2024-03-28 17:44:20

1,4-Butanediol Properties

Melting point 16 °C (lit.)
Boiling point 230 °C (lit.)
Density 1.017 g/mL at 25 °C (lit.)
vapor density 3.1 (vs air)
vapor pressure <0.1 hPa (20 °C)
refractive index n20/D 1.445(lit.)
Flash point 135 °C
storage temp. Store below +30°C.
pka 14.73±0.10(Predicted)
form Liquid
color Clear colorless
Odor Odorless
PH 7-8 (500g/l, H2O, 20℃)
explosive limit 1.95-18.3%(V)
Viscosity 83.2mm2/s
Water Solubility Miscible
Sensitive Hygroscopic
BRN 1633445
Dielectric constant 30.0(30℃)
Stability Stable. Combustible. Incompatible with strong oxidizing agents, mineral acids, acid chlorides, acid anhydrides.
InChIKey WERYXYBDKMZEQL-UHFFFAOYSA-N
LogP -0.88 at 25℃
Indirect Additives used in Food Contact Substances 1,4-BUTYLENE GLYCOL
FDA 21 CFR 175.105; 175.300; 177.1680
CAS DataBase Reference 110-63-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 7XOO2LE6G3
NIST Chemistry Reference 1,4-Butanediol(110-63-4)
EPA Substance Registry System 1,4-Butanediol (110-63-4)
Cosmetics Info Butylene Glycol

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H336
Precautionary statements  P261-P264-P270-P271-P301+P312-P304+P340+P312
Hazard Codes  Xn
Risk Statements  22-67
Safety Statements  36-23-24/25
WGK Germany  1
RTECS  EK0525000
Autoignition Temperature 698 °F
TSCA  Yes
HS Code  29053980
Toxicity LD50 orally in Rabbit: 1525 mg/kg LD50 dermal Rabbit > 2000 mg/kg
NFPA 704
1
1 0

1,4-Butanediol price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.01532 1,4-Butanediol for synthesis 110-63-4 1l $48.5 2024-03-01 Buy
Sigma-Aldrich 8.01532 1,4-Butanediol for synthesis 110-63-4 2.5L $94.8 2024-03-01 Buy
Sigma-Aldrich 240559 1,4-Butanediol ≥99% 110-63-4 2g $21.18 2024-03-01 Buy
Sigma-Aldrich 240559 1,4-Butanediol ≥99% 110-63-4 100g $104 2024-03-01 Buy
Alfa Aesar L03491 1,4-Butanediol, 99% 110-63-4 250g $32.2 2024-03-01 Buy
Product number Packaging Price Buy
8.01532 1l $48.5 Buy
8.01532 2.5L $94.8 Buy
240559 2g $21.18 Buy
240559 100g $104 Buy
L03491 250g $32.2 Buy

1,4-Butanediol Chemical Properties,Uses,Production

Chemical Properties

1,4-butanediol (1,4-BD) is a colorless, viscous liquid derived from butane by placement of alcohol groups at each end of its molecular chain and is one of four stable isomers of butanediol.the hydroxyl function of each end group of the Butanediol reacts with different mono- and bifunctional reagents: for example with dicarboxylic acids to polyesters, with diisocyanates to polyurethanes, or with phosgene to polycarbonates. 1.4-Butanediol (BDO) is a high-quality intermediate. BDO and its derivatives are widely used for producing plastics, solvents, electronic chemicals and elastic fibers. Additionally BDO is also a building block for the synthesis of polyesterpolyols and polyetherpolyols. BASF is the most significant producer of 1,4-Butanediol and its derivatives worldwide.

Uses

  1. Butanediol and its derivatives is used in a broad spectrum of applications in the chemical industry; amongst others in the manufacturing of technical plastics, polyurethanes, solvents, electronic chemicals and elastic fibres.
  2. 1,4-Butanediol is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide.
  3. 1,4-Butanediol's largest use is within tetrahydrofuran (THF) production, used to make polytetramethylene ether glycol, which goes mainly into spandex fibers, urethane elastomers, and copolyester ethers.
  4. It is commonly used as a solvent in the chemical industry to manufacture gamma-butyrolactone and elastic fibers like spandex.
  5. It is used as a cross-linking agent for thermoplastic urethanes, polyester plasticizers, paints and coatings.
  6. It undergoes dehydration in the presence of phosphoric acid yielded teterahydrofuran, which is an important solvent used for various applications.
  7. It acts an intermediate and is used to manufacture polytetramethylene ether glycol (PTMEG), polybutylene terephthalate (PBT) and polyurethane (PU).
  8. It finds application as an industrial cleaner and a glue remover.
  9. 1,4-butanediol is also used as a plasticiser (e.g. in polyesters and cellulosics), as a carrier solvent in printing ink, a cleaning agent, an adhesive (in leather, plastics, polyester laminates and polyurethane footwear), in agricultural and veterinary chemicals and in coatings (in paints, varnishes and films).

Uses

butylene glycol is a solvent with good antimicrobial action. It enhances the preservative activity of parabens. Butylene glycol also serves as a humectant and viscosity controller, and to mask odor.

Uses

1,4-Butanediol is used to produce polybutyleneterephthalate, a thermoplastic polyester;and in making tetrahydrofuran, butyrolactones,and polymeric plasticizers.

Definition

ChEBI: Butane-1,4-diol is a butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p. 16℃) with a high boiling point (230℃), it is mainly used for the production of other organic chemicals, particularly the solvent oxolane (also known as tetrahydrofuran or THF). It has a role as a neurotoxin, a protic solvent and a prodrug. It is a butanediol and a glycol.

Production Methods

Methods of manufacturing:
The most prevalent 1,4-BD production route worldwide is BASF's Reppe process, which reacts acetylene and formaldehyde. Acetylene reacts with two equivalents of formaldehyde to form 1,4-butynediol, also known as but-2-yne- 1,4-diol. Hydrogenation of 1,4-butynediol gives 1,4-butanediol. 1,4-BD is also made on a large industrial scale by continuous hydrogenation of the 2-butyne- 1,4-diol over modified nickel catalysts. The one-stage flow process is carried out at 80 - 160 deg C and 300 bar.
Mitsubishi uses a three-step process:
(1) the catalytic reaction of butadiene and acetic acid yields 1,4-diacetoxy-2-butene;
(2) subsequent hydrogenation gives 1,4-diacetoxybutane; and
(3) hydrolysis leads to 1,4-butanediol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 36, p. 2018, 1971 DOI: 10.1021/jo00813a043
Tetrahedron Letters, 33, p. 6371, 1992 DOI: 10.1016/S0040-4039(00)60976-0

General Description

Odorless colorless liquid or solid (depending upon temperature).

Air & Water Reactions

Highly flammable. 1,4-Butanediol is hygroscopic. Water soluble.

Reactivity Profile

1,4-Butanediol is heat and light sensitive. 1,4-Butanediol reacts with acid chlorides, acid anhydrides and chloroformates; reacts with oxidizing agents and reducing agents. 1,4-Butanediol is incompatible with isocyanates and acids; also incompatible with peroxides, perchloric acid, sulfuric acid, hypochlorous acid, nitric acid, caustics, acetaldehyde, nitrogen peroxide and chlorine.

Hazard

Toxic by ingestion.

Health Hazard

The acute toxic effects are mild. 1,4-Butanediolis less toxic than its unsaturate analogs,butenediol and the butynediol. The oralLD50 value in white rats and guinea pigsis ~2 mL/kg. The toxic symptoms fromingestion may include excitement, depressionof the central nervous system, nausea, anddrowsiness.

Health Hazard

Ingestion of large amounts needed to produce any symptoms.

Fire Hazard

Nonflammable liquid, flash point (open cup) 121°C.

Safety Profile

A human poison by an unspecified route. Moderately toxic byingestion and intraperitoneal routes. Human systemic effects: altered sleep time. Combustible when exposed to heat or flame. To fight fire, use alcohol foam, mist, foam, CO2, dry chemical. Incompatible with oxidizing materials. When heated to decomposition it emits acrid smoke and fumes.

Solubility in water

1,4-Butanediol is soluble in water, alcohols, esters, ketones, glycol ethers and glycol ether acetates (Butanediols, Butenediol, and Butynediol).

Purification Methods

Distil the glycol and store it over Linde type 4A molecular sieves, or crystallise it twice from anhydrous diethyl ether/acetone, and redistil it. It has been recrystallised from the melt and doubly distilled in vacuo in the presence of Na2SO4. [Beilstein 1 IV 2515.]

106-65-0
110-63-4
Synthesis of 1,4-Butanediol from Dimethyl succinate
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View Lastest Price from 1,4-Butanediol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,4-Butanedi/BDO pictures 2024-03-28 1,4-Butanedi/BDO
110-63-4
US $30.00 / kg 1kg 98% 2000kg hebei hongtan Biotechnology Co., Ltd
1,4-Butanediol pictures 2024-03-28 1,4-Butanediol
110-63-4
US $30.00 / g 10g 98% 2000kg hebei hongtan Biotechnology Co., Ltd
1,4-Butanediol  pictures 2024-03-28 1,4-Butanediol
110-63-4
US $1.00-2.00 / kg 1kg 99% 100ton/ month Nanjing Deda New Material Technology Ltd.
  • 1,4-Butanediol pictures
  • 1,4-Butanediol
    110-63-4
  • US $30.00 / g
  • 98%
  • hebei hongtan Biotechnology Co., Ltd
  • 1,4-Butanediol  pictures
  • 1,4-Butanediol
    110-63-4
  • US $1.00-2.00 / kg
  • 99%
  • Nanjing Deda New Material Technology Ltd.
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