ChemicalBook
Chinese Japanese Germany Korea

N-Acetylsulfanilyl chloride

N-Acetylsulfanilyl chloride
N-Acetylsulfanilyl chloride structure
CAS No.
121-60-8
Chemical Name:
N-Acetylsulfanilyl chloride
Synonyms
ASC;NASC;CARD5;NSC 127860;dagenanchloride;acetylsulfanilyl;Dagenan chloride;N-Acetylsulfanilyl;N-Acetylsulfanilyl c;acetylsulfanilylchloride
CBNumber:
CB4452614
Molecular Formula:
C8H8ClNO3S
Formula Weight:
233.67
MOL File:
121-60-8.mol

N-Acetylsulfanilyl chloride Properties

Melting point:
142-145 °C (dec.)(lit.)
Boiling point:
426.8±28.0 °C(Predicted)
Density 
1.2977 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
Sealed in dry,2-8°C
pka
13.75±0.70(Predicted)
form 
Granular Crystalline Powder or Crystals
color 
White to cream-beige
Water Solubility 
SLIGHTLY SOLUBLE
Sensitive 
Moisture Sensitive
Merck 
14,103
BRN 
746676
CAS DataBase Reference
121-60-8(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
LIX4M9AIVM
NIST Chemistry Reference
P-acetamidobenzene sulfonyl chloride(121-60-8)
EPA Substance Registry System
Benzenesulfonyl chloride, 4-(acetylamino)- (121-60-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H290-H302+H312+H332-H318-H314-H335
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P501a-P261-P280-P305+P351+P338-P310-P234-P260-P264-P270-P271-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501
Hazard Codes  C
Risk Statements  22-34-37
Safety Statements  26-36/37/39-45-28B
RIDADR  UN 3261 8/PG 2
WGK Germany  3
RTECS  DB8837500
9-21
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29242995
Toxicity LD50 oral in rat: > 3200mg/kg

N-Acetylsulfanilyl chloride price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 112747 N-Acetylsulfanilyl chloride 98% 121-60-8 100g $46.8 2021-12-16 Buy
Sigma-Aldrich 112747 N-Acetylsulfanilyl chloride 98% 121-60-8 1kg $135 2021-12-16 Buy
TCI Chemical A0074 4-Acetamidobenzenesulfonyl Chloride >98.0%(HPLC)(T) 121-60-8 25g $106 2021-12-16 Buy
TCI Chemical A0074 4-Acetamidobenzenesulfonyl Chloride >98.0%(HPLC)(T) 121-60-8 100g $374 2021-12-16 Buy
Usbiological A3598-05 ASC 121-60-8 100ug $459 2021-12-16 Buy

N-Acetylsulfanilyl chloride Chemical Properties,Uses,Production

Chemical Properties

OFF-WHITE TO SLIGHTLY GREY GRANULAR CRYST. POWDER

Uses

A sulfanilamide derivative of Chitosan

Uses

Intermediate in the preparation of sulfanilamide and its derivatives.

Uses

N-Acetylsulfanilyl chloride is used?in the preparation of sulfanilamide and its derivatives which are intermediates to produce sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. It is also used as a Pharma raw material. N-Acetylsulfanilyl chloride widely used in the fields of dye, medicine, mainly used for preparation of Sulfanilamide, Sulfanilylureal, Sulfatolamide, Sulphathiourea , Sulfaguanidine and Sulfacetamide and etc.

Biotechnological Production

After more than three decades of strain and process optimization, the 2KGA fermentation by K. vulgare has reached a performance level that makes it increasingly difficult to achieve further cost-relevant improvements. Instead, opportunities can be seen in the succeeding step of 2KGA rearrangement to ascorbic acid, which still follows the same concept as laid out in the 1930s by Reichstein and Grüssner. This chemical step contributes significantly to the overall process costs. A process Industrial Production of L-Ascorbic Acid (Vitamin C) and D-Isoascorbic Acid 171 concept that could convert sorbitol directly to ascorbic acid would therefore be most attractive. In theory, this could build on the established 2KGA fermentation with an enzyme-catalyzed 2KGA to Asc rearrangement (2,6-hemiacetal to 1,4- lactone) as extension. Ab initio energy calculations as well as experimental results (own unpublished results) indicate that in aqueous environment, Asc is thermodynamically far more stable than 2KGA and (nearly) quantitative conversion should be possible. However, no enzyme efficiently catalyzing this reaction has so far been identified. The few publications of enzyme catalysis for this reaction so far shows only trace activity and no significant improvements have been reported. 2KGA may represent a kinetic trap in an aqueous environment and biotechnological reaction pathways all the way to Asc may need to avoid 2KGA. Accordingly, 2KGA is also not part of natural biosynthetic routes, where Asc formation directly results from the oxidation of precursor molecules with appropriately preformed 1,4-lactone linkage (L-gulono-1,4-lactone in animals, L-galactono-1,4-lactone in plants). Enzymes converting L-gulono-1,4-lactone to Asc are also known from bacteria, even from Ketogulonicigenium. The biochemical description of the Ketogulonicigenium enzyme indicates that it belongs to the family of heterotrimeric periplasmic flavohemoproteins, of which several can be found in the published Ketogulonicigenium genomes. Besides sharing the same FAD cofactor, these enzymes bear no similarity to the mammalian gulono-1,4- lactone dehydrogenase. The use of these natural or nature-like Asc-forming enzymatic steps in biotechnological production processes is so far precluded by the rare nature of these L-sugar-derived lactone precursor molecules and the lack of efficient production methods for these compounds. It was, therefore, a tantalizing discovery when Asc formation directly from L-sorbosone, the intermediate of the efficient 2KGA formation route, was identified in those two species already in the focus for 2KGA production for decades: K. vulgare and G. oxydans. Besides an earlier report of L-sorbosone to Asc activity derived from plant tissue , which did not see consolidating follow-ups, the above observations are the first evidence of biological Asc formation from a molecule other than a 1,4-lactone.

Safety Profile

A poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic vapors of NOx, SOx, and Cl.

Purification Methods

Crystallise the chloride from toluene, CHCl3, or ethylene dichloride. [Beilstein 14 IV 2703.]

N-Acetylsulfanilyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products


N-Acetylsulfanilyl chloride Suppliers

Global( 285)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15427 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com China 1807 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9134 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com
+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5942 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from N-Acetylsulfanilyl chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-08-28 N-Acetylsulfanilyl chloride
121-60-8
US $195.00 / KG 1KG 99%min 1000 Kilogram/Kilograms per Month Hebei Runbin Biotechnology Co. LTD
2020-01-08 N-Acetylsulfanilyl chloride
121-60-8
US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
2019-07-06 ASCORBATE OXIDASE
121-60-8
US $1.00 / kg 1kg 95%-99% 100kg Career Henan Chemical Co

N-Acetylsulfanilyl chloride Spectrum


121-60-8(N-Acetylsulfanilyl chloride)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved