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4'-Methylthioacetophenone

4'-Methylthioacetophenone Structure
4'-Methylthioacetophenone structure
CAS No.
1778-09-2
Chemical Name:
4'-Methylthioacetophenone
Synonyms
Ethanone, 1-[4-(methylthio)phenyl]-;4-(METHYLTHIO)ACETOPHENONE;4-(Methyl thio);p-Acetylthioanisole;4'-Methylthioacetoph;Glycerol Impurity 24;4-(ACETYL)THIOANISOLE;Etoricoxib Impurity 61;4-THIOMETHYLACETOPHENONE;4'-Methylthioacetophenone
CBNumber:
CB4454274
Molecular Formula:
C9H10OS
Molecular Weight:
166.24
MDL Number:
MFCD00039835
MOL File:
1778-09-2.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06
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4'-Methylthioacetophenone Properties

Melting point 80-82 °C(lit.)
Boiling point 135 °C
Density 1.1369 (rough estimate)
refractive index 1.5600 (estimate)
Flash point 135°C/1mm
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Methanol
form Solid
color White to Off-White
BRN 1860517
CAS DataBase Reference 1778-09-2(CAS DataBase Reference)
FDA UNII FN9JM37X2P
NIST Chemistry Reference 4-CH3S-C6H4-COCH3(1778-09-2)
EPA Substance Registry System 4'-(Methylmercapto)acetophenone (1778-09-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
Hazard Note  Irritant
HS Code  29309099
NFPA 704
1
2 0

4'-Methylthioacetophenone price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 396583 4′-(Methylthio)acetophenone 97% 1778-09-2 1g $28.9 2024-03-01 Buy
TCI Chemical M1672 4'-(Methylthio)acetophenone >98.0%(GC) 1778-09-2 5g $71 2024-03-01 Buy
TCI Chemical M1672 4'-(Methylthio)acetophenone >98.0%(GC) 1778-09-2 25g $207 2024-03-01 Buy
Alfa Aesar L18074 4'-(Methylthio)acetophenone, 99% 1778-09-2 5g $88.65 2024-03-01 Buy
Alfa Aesar L18074 4'-(Methylthio)acetophenone, 99% 1778-09-2 25g $323.65 2024-03-01 Buy
Product number Packaging Price Buy
396583 1g $28.9 Buy
M1672 5g $71 Buy
M1672 25g $207 Buy
L18074 5g $88.65 Buy
L18074 25g $323.65 Buy

4'-Methylthioacetophenone Chemical Properties,Uses,Production

Chemical Properties

White to light yellow crystal powde

Uses

4′-(Methylthio)acetophenone may be used for the synthesis of Vioxx (Rofecoxib), an non-steroidal anti-inflammatory drug (NSAID). It may be used in the synthesis of (E)-1-[4-(methylsulfanyl)phenyl]-3-phenylprop-2-en-1-one.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 2857, 1951 DOI: 10.1021/ja01150a127
The Journal of Organic Chemistry, 56, p. 5955, 1991 DOI: 10.1021/jo00020a048

General Description

4′-(Methylthio)acetophenone (4-(Methylthio)acetophenone, p-(methylthio) acetophenone, 4-MTAP) is a sulphur containing organic building block. It is a key intermediate in drug synthesis. Its industrial preparation, via Friedel-Crafts acylation reaction in the presence of aluminium chloride as catalyst and acetyl chloride as acylating agent has been reported. It has been prepared by the acetylation reaction of thioanisole with acetic anhydride in the presence of solid acid catalyst.

4'-Methylthioacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

2-(4-METHYLTHIOPHENYL)PYRIDINE JR-13707, 3-(4-(Methylthio)phenyl)-1H-pyrazol-5-amine, 97% Ethyl 3-[4-(Methylsulfanyl)phenyl]-3-oxopropanoate

4'-Methylthioacetophenone Suppliers

Global( 246)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 6992 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5909 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10828 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Shandong chuangyingchemical Co., Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from 4'-Methylthioacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4 2021-07-02 4"-Methylthioacetophenone
1778-09-2
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
4'-Methylthioacetophenone pictures 2019-07-06 4'-Methylthioacetophenone
1778-09-2
 US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co

4'-Methylthioacetophenone Spectrum

4'-Methylthioacetophenone(1778-09-2)1HNMR4'-Methylthioacetophenone(1778-09-2)FT-IR4'-Methylthioacetophenone(1778-09-2)IR

1778-09-2(4'-Methylthioacetophenone)Related Search:

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4-(Methyl thio) Ethanone,1-[4-(methylthio) 4-(METHYLTHIO)ACETOPHENONE 99% 4-THIOMETHYLACETOPHENONE Dodecane-1-sulfonyl chloride 1-Acetyl-4-(methylthio)benzene Methyl 4-acetylphenyl sulfide Methyl(4-acetylphenyl) sulfide p-Acetylthioanisole 4'-(Methylthio)acetophenone,97% 4'-Methylthioacetoph 1-[4-(Methylsulfanyl)phenyl]ethan-1-one 1-[4-(Methylsulphanyl)phenyl]ethan-1-one, 4-Acetylthioanisole 1-[4-(METHYLSULFANYL)PHENYL]ETHANONE 1-[4-(methylthio)phenyl]ethan-1-one 1-[4-(METHYLTHIO)PHENYL]ETHANONE 4-METHYLMERCAPTOACETOPHENONE 4'-(METHYLTHIO)ACETOPHENONE P-(METHYLTHIO)ACETOPHENONE 4-(ACETYL)THIOANISOLE 4'-(Methylthio)acetophenone> Etoricoxib Impurity 61 Ethanone, 1-[4-(methylthio)phenyl]- 4-(METHYLTHIO)ACETOPHENONE 4 ′- (meththyl) phenylacetone Glycerol Impurity 24 4'-Methylthioacetophenone 1778-09-2 C9H10OS CH3SC6H4COCH3 Organic Building Blocks Sulfur Compounds Sulfides/Disulfides Building Blocks Osteoarthritis and Rheumatoid Arthritis Organic Building Blocks Sulfides/Disulfides Sulfur Compounds Aromatic Acetophenones & Derivatives (substituted)