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D(+)-Trehalose dihydrate

CAS No.
6138-23-4
Chemical Name:
D(+)-Trehalose dihydrate
Synonyms
TREHALOSE DIHYDRATE;D-TREHALOSE;D-TREHALOSE DIHYDRATE;Trehalose (hydrate);ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSIDE DIHYDRATE;Haizaotang;Trehalose 99;D-(+)-TrehaL;ose dihydrate;Trehalose2H2O
CBNumber:
CB4454890
Molecular Formula:
C12H22O11·2H2O
Molecular Weight:
378.33
MDL Number:
MFCD00071594
MOL File:
6138-23-4.mol
MSDS File:
SDS
Last updated:2024-03-08 15:21:44

D(+)-Trehalose dihydrate Properties

Melting point 97-99 °C(lit.)
Boiling point 115.3 °C
alpha 179 º (c=2, H2O)
FEMA 4600 | TREHALOSE, DIHYDRATE
refractive index 181 ° (C=7, H2O)
storage temp. room temp
solubility H2O: 50 mg/mL
form powder
color White to Off-White
optical activity [α]20/D +179±3°, c = 2% in H2O
Water Solubility 68.9 g/100 mL (20 ºC)
Sensitive Hygroscopic
Merck 14,9580
BRN 5322018
InChIKey DPVHGFAJLZWDOC-NYAOJISMSA-N
CAS DataBase Reference 6138-23-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) TREHALOSE, DIHYDRATE
FDA UNII 7YIN7J07X4

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  38-36/37/38
Safety Statements  37/39-26-24/25
WGK Germany  2
RTECS  LZ5776547
3-10
TSCA  Yes
HS Code  29400000
NFPA 704
1

D(+)-Trehalose dihydrate price More Price(76)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 90210 D-(+)-Trehalose dihydrate for microbiology, ≥99.0% 6138-23-4 50g $241 2024-03-01 Buy
Sigma-Aldrich 625625 Trehalose, Dihydrate - CAS 6138-23-4 - Calbiochem Non-reducingdisaccharidewhichyields2molesofD-glucoseuponacidhydrolysis 6138-23-4 50g $112 2024-03-01 Buy
Sigma-Aldrich 1673715 Trehalose United States Pharmacopeia (USP) Reference Standard 6138-23-4 400mg $491 2024-03-01 Buy
Sigma-Aldrich 1.02776 Trehalose dihydrate EMPROVE? EXPERT, Ph. Eur., ChP, NF, JP 6138-23-4 1KG $1086 2024-03-01 Buy
Sigma-Aldrich 1.02776 Trehalose dihydrate EMPROVE? EXPERT, Ph. Eur., ChP, NF, JP 6138-23-4 12KG $7273 2024-03-01 Buy
Product number Packaging Price Buy
90210 50g $241 Buy
625625 50g $112 Buy
1673715 400mg $491 Buy
1.02776 1KG $1086 Buy
1.02776 12KG $7273 Buy

D(+)-Trehalose dihydrate Chemical Properties,Uses,Production

Description

Trehalose is a natural non-reducing disaccharide composed of two α-glucose units. It is found in all major groups of organisms except vertebrates, has biological functions as an osmolyte, storage reserve, and stress protectant, and has diverse commercial applications. Trehalose can also induce or enhance autophagy.

Chemical Properties

white to off-white crystalline powder

Chemical Properties

D(+)-Trehalose dihydrate occurs as virtually odorless, white or almost white crystals with a sweet taste (approximately 45% of the sweetness of sucrose).

Uses

D-(+)-Trehalose is a disaccharide composed of two α-glucose units. D-(+)-Trehalose is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations. D-(+)-Trehalose is also used as a protein stabilize.

Uses

Stabilizes cells during freezing, freeze-drying and air-drying. Sweetener and stabilizer in foods; cryoprotectant for freeze-dried foods. Additive in cosmetics and personal care products.

Uses

An osmolyte, chemical chaperone, and inducer of autophagy.D-(+)-Trehalose is a disaccharide composed of two α-glucose units. D-(+)-Trehalose is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations. D-(+)-Trehalose is also used as a protein stabilizer.

Uses

Food additive; pharmaceutical excipient

Production Methods

Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.

General Description

Trehalose is a naturally occurring disaccharide which is used as a nontoxic cryoprotectant of enzymes, membranes and vaccines. It serves as a carbohydrate reserve in microorganisms and protects them from adverse conditions.

Pharmaceutical Applications

D(+)-Trehalose dihydrate is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.

Biochem/physiol Actions

Trehalose is a non-reducing sugar formed from two glucose units joined by a 1-1 alpha bond. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.

Safety

Trehalose is used in cosmetics, foods, and parenteral and nonparenteral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
In the gut, trehalose is rapidly metabolized to glucose by the specific enzyme trehalase. A small minority of the population exhibits a primary (hereditary) or secondary (acquired) trehalase deficiency and thus may experience intestinal discomfort after ingestion of excessive amounts of trehalose owing to the osmotic activity of undigested trehalose in the gut. However, smaller amounts of trehalose are tolerated by such individuals without any symptoms.
Trehalose is used as a sweetener and is reported to have substantially less cariogenic potential than sucrose.
LD50 (dog, IV): >1 g/kg
LD50 (dog, oral): >5 g/kg
LD50 (mouse, IV): >1 g/kg
LD50 (mouse, oral): >5 g/kg
LD50 (rat, IV): >1 g/kg
LD50 (rat, oral): >5 g/kg

storage

Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
Trehalose should be stored in a cool, dry place in a well-sealed container.

Purification Methods

α,α-D(+)-Trehalose crystallises (as the dihydrate) from aqueous EtOH. Dry it at 13o. For the anhydrous compound dissolve 10g in pyridine (200mL) and distil off this solvent at atmospheric pressure, and when the temperature rises to 115.3o all the H2O is removed and 73mL of distillate is collected. Most of the anhydrous material crystallises out at this stage. The crystals are collected (6.8g), washed with Et2O to give 6.1g of anhydrous product. Higher yields are obtained by slightly more prolonged distillation. [Birch J Chem Soc 3489 1965, X-ray cryst: Brown et al. Acta Cryst 28 3145 1972, Beilstein 17/8 V 3.]

Incompatibilities

Trehalose is incompatible with strong oxidizing agents, especially in the presence of heat.

Regulatory Status

GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.

D(+)-Trehalose dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 460)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Shandong Juchuang Chemical Co., LTD
+86-18885615001 +86-18885615001 admin@juchuangchem.com China 387 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14936 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Accela ChemBio Inc.
(+1)-858-699-3322 info@accelachem.com United States 19965 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58

View Lastest Price from D(+)-Trehalose dihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D(+)-Trehalose dihydrate pictures 2024-03-11 D(+)-Trehalose dihydrate
6138-23-4
US $20.00-5.00 / kg 500kg 99.9 200tons Shandong Juchuang Chemical Co., LTD
D(+)-Trehalose dihydrate pictures 2023-08-02 D(+)-Trehalose dihydrate
6138-23-4
US $0.00-0.00 / kg 1kg 0.99 50000kg Hebei Yibangte Import and Export Co. , Ltd.
D(+)-Trehalose dihydrate pictures 2023-06-29 D(+)-Trehalose dihydrate
6138-23-4
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
D-ALPHA,ALPHA-TREHALOSE DIHYDRATE D(+)-TREHALOSE D-(+)-TREHALOSE DIHYDRATE D(+)TREHALOSE DIHYDRATE CELL*CULTURE TES TED D(+)-TREHALOSE DIHYDRATE, FOR MICRO-BIOL OGY .alpha.-D-Glucopyranoside, .alpha.-D-glucopyranosyl, dihydrate d(+)-trehalose dihydrate, mycose a,a-D-Trehaloseendotoxinfree D-(+)-TREHALOSE,DIHYDRATE,POTATO D-TREHALOSE DIHYDRATE extrapure CHR α,α-Trehalose, D-(+)-Trehalose dihydrate, α-D-Glucopyranosyl-α-D-glucopyranoside α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside D(+)-Trehalose dihydrate 99% Trehalose·2hydrate α,α-Trehalose·2hydrate α-D-Glucopyranosyl α-D-glucopyranoside·dihydrate A-D-GLUCOPYRANOSYL-A-D-GLUCOPYRANOSIDE DIHYDRATE D-(+)-TREHALOSE DIHYDATE D-TREHALOSE.2H2OANALYTICAL GRADE D-(+)-Trehalose dihydrate,α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside D(+)-Trehalose dihyd D(+)-Trehalose dihydrate,99% Trehalose (400 mg) TREHALOSE DIHYDRATE, D-(+)-(RG) Trehalose dihydrat a-D-Glucopyranoside, a-D-glucopyranosyl, hydrate (1:2) 1-O-ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSIDE DIHYDRATE A,A-TREHALOSE DIHYDRATE A,A-D-TREHALOSE DIHYDRATE A-D-GLUCOPYRANOSYL-A-D-GLUCOPYRANOSIDE ALPHA-D-GLUCOPYRANOSIDE DIHYDRATE ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSIDE ALPHA-D-GLUCOPYRANOSYL DIHYDRATE ALPHA,ALPHA-D-TREHALOSE DIHYDRATE ALPHA,ALPHA-TREHALOSE DIHYDRATE MYCOSE DIHYDRATE TREHALOSE, D-(+)- alpha-D-Glucopypranosyl-alpha-D-glucopyranoside D-(+)-TREHALOSE DIHYDRATE FROM*SACCHAROM YCES CEREVI D(+)TREHALOSE REDUCED METAL ION CONTENT DIHYDRATE Trehalose Dihydrate,D(+)-Trehalose dihydrate D-(+)-Trehalose dihydrate Vetec(TM) reagent grade, >=99% MAGNESIUM 1000PPM FOR ICP-MS PHOSPHORIC ACID 150 ML/L a,a-D-Trehalose dihydrate endotoxin free D-(+)-TREHALOSE DIHYDRATE, FROM STAR D(+)TREHALOSE REDUCED METAL ION CONT D(+)-Trehalose dihydrate (for injection) D-(+)-Trehalose dihydrate (D-Trehalose dihydrate D-(+)-Trehalose dihydrate (Synonyms: D-Trehalose dihydrate ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYR D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae D-(+)-Trehalose Dihydrate> Trehalose 99 Trehalose dihydrate CRS Trehalose, Endotoxin Free Trehalose (for injection) D-(+)-TrehaL