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L-carnitine

Indications and Usage Mechanisms of Action Pharmacokinetics
L-carnitine
L-carnitine
CAS No.
541-15-1
Chemical Name:
L-carnitine
Synonyms
CAR-OH;ST 198;karnitin;USPorFCC;Carnitor;Carniking;Carnitene;VITAMIN BT;Carnitrine;L-carntine
CBNumber:
CB4464378
Molecular Formula:
C7H15NO3
Formula Weight:
161.2
MOL File:
541-15-1.mol

L-carnitine Properties

Melting point:
197-212 °C(lit.)
alpha 
-31 º (c=10, H2O)
Boiling point:
287.5°C (rough estimate)
Density 
0.64 g/cm3
refractive index 
-32 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL at 20 °C, clear, colorless
form 
Crystals or Crystalline Powder
pka
3.80(at 25℃)
color 
White
PH
6.5-8.5 (50g/l, H2O)
Water Solubility 
2500 g/L (20 ºC)
Merck 
14,1849
BRN 
4292315
Stability:
Hygroscopic
CAS DataBase Reference
541-15-1(CAS DataBase Reference)

SAFETY

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  BP2980000
3-10
Hazard Note  Irritant
HS Code  29239000
Hazardous Substances Data 541-15-1(Hazardous Substances Data)

L-carnitine price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.40092 L-Carnitine for synthesis 541-15-1 1EA $90.5 2017-11-08 Buy
Sigma-Aldrich 1359903 Levocarnitine United States Pharmacopeia (USP) Reference Standard 541-15-1 400mg $348.4 2017-11-08 Buy
TCI Chemical C0049 L-Carnitine >98.0%(T) 541-15-1 5g $40 2017-11-08 Buy
TCI Chemical C0049 L-Carnitine >98.0%(T) 541-15-1 25g $121 2017-11-08 Buy
Alfa Aesar A17618 L-Carnitine, 99+% 541-15-1 10g $96.1 2017-11-08 Buy

L-carnitine Chemical Properties,Uses,Production

Indications and Usage

Carnitine is a type of vitamin B, and its structure is similar to that of amino acids. It is mainly used to help transport long-chain fatty acids to provide energy and to prevent fat from collecting in the heart, liver, and skeletal muscles. Carnitine can prevent disordered fat metabolism due to diabetes, fatty liver disease and heart disease, and it can reduce heart damage, lower blood triglyceride, aid in weight loss, and increase the antioxidant effects of vitamin E and C. Meats and giblets are high in carnitine. Artificially synthesized carnitine includes L-carnitine, D-carnitine, and DL-carnitine, and only L-carnitine has physiological activities. On the other hand, D-carnitine and DL-carnitine competitively inhibit the activity of carnitine acetyltransferase (CAT) and carnitine palmitoyltransferase (PTC) to prevent cells’ fat metabolism, thus harming human nutrition. L-carnitine was first discovered in 1905 by Russian chemists Gulewitsch and Krimberg in infusion broth, and its chemical structure was determined in 1927 by Tomita and Senju. L-carnitine is a white crystalline or transparent powder, and its melting point is 200℃ (decompose). It is easily soluble in water, lye, methanol and ethanol, barely soluble in acetone and acetate, and insoluble in chloroform. It is hygroscopic. L-carnitine can be used as an animal nutrition enhancer, and it is mainly used to enhance protein-based food additives to promote fat absorption and utilization. L-carnitine also is a nutrition enhancer that is mainly used in soy-based infant foods, sports nutritional foods and weight loss foods to promote fat absorption and utilization. According to China’s regulations, the permitted amount in biscuits, drinks, and dairy beverages is 600-3000mg/kg; in solid beverages, liquids, and gel capsules, 250-600mg/kg; in formula, 300-400mg/kg; in infant foods, 70-90mg/kg (1g tartrate is equivalent to 0.68g l-carnitine). L-carnitine can also be used as an appetite booster. L-carnitine affects the elimination and utilization of ketone bodies, so it can be used as a biological antioxidant to eliminate free radicals, maintain membrane stability, increase animal immunity and resistance to disease and stress. Oral L-carnitine can increase the speed of sperm maturation and sperm vitality, it can increase the number of forward-moving sperm and motile sperm in oligospermia and asthenospermia patients, thus increasing the women’s clinical pregnancy rate, and it does so safely and effectively. L-carnitine can bind with organic acids and the large amounts of acyl coenzyme derivatives produced in children with fatty acid metabolism disorder and turn them into water soluble acylcarnitine to be excreted through urine. This not only aids in controlling acute acidosis occurrences, but also effectively improves long-term prognosis.

Mechanisms of Action

L-carnitine cannot participate in protein biosynthesis, but it promotes ketone body utilization and nitrogen generation to an extent. Its main function is to promote fatty acid beta oxidation, which occurs in the liver and the mitochondria of other tissue cells. It is known that free fatty acids and acyl coenzyme A cannot penetrate the inner mitochondrial membrane, but acylcarnitine can do so swiftly. Thus, it is determined that L-carnitine is the carrier that transports fatty acid and acyl forms into the mitochondrial membrane. The mechanisms of this transporting process are still unknown, but it is certain that carnitine acyl-CoA transferase is the key enzyme in this process. It has two isoenzymes, one of which is carnitine acyl-CoA transferase I, positioned on the outer side of the membrane. When fatty acid is catalyzed by acyl-CoA-synthatase to produce acyl-CoA, it is transported by carnitine acyl-CoA transferase I into the membrane. After it has entered the membrane, it is catalyzed by the second isoenzyme - carnitine acyl-CoA transferase II – to turned into a form of acyl-CoA that can be directly utilized by fatty acid catabolic enzymes. Afterwards, it releases energy through processes such as dehydrogenation and deoxygenation.
L-carnitine can also adjust the acyl ratio in mitochondria, thus affecting energy metabolism. L-carnitine can participate in the transportation of branched chain amino acid metabolites, which encourages the regular metabolism of branched chain amino acid.

Pharmacokinetics

L-Carnitine is very easily soluble in water, and can be entirely absorbed by the human body when consumed through food. It is known that the small intestine absorbs L-carnitine, but there is little known about the specific absorption process of carnitine (free or esterified) through intestine mucosa and about the specific absorption area. Besides external food sources of carnitine, humans can also synthesize carnitine with their own bodies. The liver and kidneys are mainly responsible for synthesizing carnitine. They progress from lysine into epsilon beta hydroxy three methyl lysine, and use aldolase and aldehyde oxidase to transform it into L-carnitine. Besides lysine, the body’s biosynthesis of L-carnitine also requires methionine, vitamin C, nicotinic acid and vitamin B6.
A rat dissection showed that carnitine is most concentrated in the adrenal gland, followed by the heart, bones, muscles, fat tissue, and liver, and the carnitine concentration in the kidneys and brain are 40 times that in blood. Human carnitine concentration has varied greatly due to inconsistencies in measuring method and test subject. The biological method of testing human blood carnitine content placed it between 0.86-2.87mg/100ml, and the enzymology method of testing muscle carnitine content placed it between 0.457-2.479μg/g. The absorbed carnitine is metabolized by the human body and excreted in urine as free carnitine.

Chemical Properties

White crystalline

Uses

antimethemoglobinemic, cyanide antidote

Uses

Essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations f ound in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.

Uses

Carniking(R) is a product for premix- and feed industry. It is particularly recommended for the enrichment of compound feed.

Uses

L-Carnitine is a natural, vitamin-like nutrient wich plays an important role inhuman metabolism. It is essential in the utilization of fatty acids and in transporting metabolic energy

Uses

Natrulon(R) RC-100 is 100% L-Carnitine. This white crystalline powder, highly hygroscopic and amino acid like material brings not only the exfoliation but also, an additional benefit of a high level of moisturization capability.

Uses

Natrulon(R) RC-50DG is a 50% solution of L-Carnitine in decaglycerol/water. Natrulon(R) RC-50DG to provide a truly multi-functional product: an exfoliating product with excellent moisturization capability.

Definition

ChEBI: The (R)-enantiomer of carnitine.

Purification Methods

The S(L) isomer is levocarnitine, Vitamin B7. The R or S isomers crystallise from EtOH/Me2CO (hygroscopic). The R or S hydrochlorides crystallise from hot EtOH or EtOH/Et2O and have m 142o(dec). The RS-isomer crystallises from hot EtOH (hygroscopic). The RS hydrochloride crystallises in needles from hot EtOH and has m 196o(dec). [(±) Mazzetti & Lemmon J Org Chem 22 228 1957, Beilstein 4 H 513, 4 I 548, 4 II 937-8, 4 III 1632-5, 4 IV 3185.]

L-carnitine Preparation Products And Raw materials

Raw materials

Preparation Products


L-carnitine Suppliers

Global( 429)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
inquiry@dakenchem.com CHINA 22144 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 294 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20803 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32765 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2549 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
bruce@xrdchem.cn CHINA 551 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales1@fine-chemtech.com CHINA 893 55
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
dana.jiang@royal-chem.com CHINA 786 55

View Lastest Price from L-carnitine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-03-28 L-Carnitine 541-15-1
541-15-1
US $10.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd
2018-09-04 541-15-1 L-carnitine Manufacturer Supply Email: cindy@hbmeihua.cn
541-15-1
US $10.00 / MG 10G 99% 30 tons per month Meihua Biological Technology Co.,Ltd
2018-07-31 L-carnitine
541-15-1
US $50.00 / KG 1KG 99% 1000kg

541-15-1(L-carnitine)Related Search:


  • CARNITINE, L-
  • CARNIFEED(R)
  • CARNIKING(R)
  • CAR-OH
  • ME3-GAMMA-ABU(BETA-HYDROXY)-OH
  • (R)-BETA-HYDROXY-GAMMA-(TRIMETHYLAMMONIO)BUTYRATE
  • (R)-3-HYDROXY-4-(TRIMETHYLAMMONIO)BUTYRATE
  • VITAMIN B-GAMMA
  • VITAMIN BT
  • VITAMIN BT INNER SALT
  • VITAMINE BT
  • Metabolic Pathways
  • Metabolites and Cofactors on the Metabolic Pathways Chart
  • Metabolomics
  • Others
  • Peptide Synthesis
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • (-)-carnitine
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  • (3-carboxy-2-hydroxypropyl)trimethyl-,hydroxide,innersalt,L-Ammonium
  • (3-carboxy-2-hydroxypropyl)trimethyl-ammoniumhydroxide,innersalt
  • (r)-carnitine
  • 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminiumhydroxide,innersalt
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  • gamma-trimethyl-ammonium-beta-hydroxybutirate
  • gamma-trimethyl-beta-hydroxybutyrobetaine
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  • Ammonium Polyhalides, etc. (Quaternary)
  • Quaternary Ammonium Compounds
  • (R)-(3-carboxy-2-hydroxypropyl)trimethylammonium hydroxide
  • levo-Carnitine base
  • Levo carnitin
  • L-carnitine Feed grade 50%
  • L-Carnitine50 %
  • L-carntine
  • L-Carntine99%
  • L-Carnitine, 99+%
  • USPorFCC
  • Levocarnitinecrystalline,USPgrade
  • 26687-82-8
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  • 4-Amino-3-hydroxybutyric acid trimethylbetaine
  • L-Carnitine-methyl-D3HCI
  • L-Carnitine-N-Methyl-D3
  • 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-
  • L-CARNITINE(FEED)
  • L-CARNITINE,FREEBASE
  • (3R)-3-hydroxy-4-trimethylammonio-butanoate
  • L-CARNITINE BASE(EP5.6TH)
  • L-CARNITINE BASE(USP29)
  • CARNITINE, L-(RG)
  • 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, (R)-
  • 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (R)-
  • Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L- (8CI)
  • Carniking
  • Carniking 50
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