Anti-ARP2 antibody, Mouse monoclonal

Uses

Anti-ARP2 antibody, Mouse monoclonal has been used in:

• Immunoblotting
• Immunocytochemistry
• Enzyme linked immuosorbent assay

General Description

Mouse Monoclonal Anti-ARP2 antibody binds to human, canine, rat, and mouse ARP2, 40-45kDa.

Biochem/physiol Actions

Actin-related protein 2 (ARP2) is a part of ARP2/3 complex and play a key role in actin filament formation. It mediates changes in the polymerization state of actin filaments. The Wiskott-Aldrich Syndrome protein (WASP) regulates ARP2/3 complex of proteins. The ARP2/3 complex and its activator spinocerebellar ataxia, autosomal recessive 2 (Scar2) are involved in Golgi polarization in NIH 3T3 cells. However in primary astrocytes, Golgi polarization involves neither actin cytoskeleton or Arp2/3 complex nor any WASP-family of proteins. In a different model, it was found that the ARP2/3 complex was necessary for neutrophil chemotaxis and phagocytosis. By genetic and loss of function studies, it was demonstrated that Scar is the major regulator of the ARP2/3 complex rather than the WASP family of proteins, the latter having more restricted roles in specific cellular events.