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Pramlintide acetate

Pramlintide acetate
Pramlintide acetate structure
CAS No.
196078-30-5
Chemical Name:
Pramlintide acetate
Synonyms
pramlintide acetate;pramlintide acetate hydrate;Tripo-aMylin Acetate Hydrate;Pramlintide Acetate, Amylin Rat;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE
CBNumber:
CB4468518
Molecular Formula:
C173H273N51O56S2
Formula Weight:
4027.46
MOL File:
196078-30-5.mol

Pramlintide acetate Properties

CAS DataBase Reference
196078-30-5(CAS DataBase Reference)
FDA UNII
726I6TE06G

Pramlintide acetate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24093 Pramlintide (acetate hydrate) ≥95% 196078-30-5 5mg $199 2018-11-19 Buy
Cayman Chemical 24093 Pramlintide (acetate hydrate) ≥95% 196078-30-5 10mg $378 2018-11-19 Buy
Cayman Chemical 24093 Pramlintide (acetate hydrate) ≥95% 196078-30-5 25mg $896 2018-11-19 Buy
Cayman Chemical 24093 Pramlintide (acetate hydrate) ≥95% 196078-30-5 50mg $1592 2018-11-19 Buy

Pramlintide acetate Chemical Properties,Uses,Production

Description

Pramlintide acetate is an injectable human amylin analog that has been launched for the treatment of both type 1 and type 2 diabetes, in conjunction with insulin. While it is also a 37-amino acid peptide, it differs from its parent predecessor by the substitution of Ala-25, Ser-28, and Ser-29 with prolines. Not only do these modifications improve the solubility of the peptide, they also eliminate the aggregation observed with amylin, resulting in a stable synthetic analog with retention of biological activity that is suitable for pharmaceutical use. As an indication of potency, Pramlintide acetate inhibits the binding of radioiodinated rat amylin to rat nucleus accumbens membranes with a Ki value of 23 pM. Its mechanism of action mimics amylin; as a neurohormone that is cosecreted with insulin from the pancreatic β cells in response to meals, it is involved in glucose homeostasis. Both peptides lower postprandial glucose levels by inhibiting glucagon and by restraining the vagus-mediated rate of gastric emptying, thereby, slowing intestinal carbohydrate absorption. Furthermore, amylin, orPramlintide acetate, has the added benefit of inducing postprandial satiety resulting in weight loss in the patients with type 2 diabetes. Since Pramlintide acetate slows gastric emptying, it is contraindicated in patients with gastroparesis and in patients taking drugs that alter gastrointestinal motility (anticholinergic agents, such as, atropine) or slow down the intestinal absorption of nutrients (such as α-glucosidase inhibitors). Pramlintide acetate is also contraindicated in patients with hypoglycemic tendencies; due to co-administration with insulin, severe insulin-induced hypoglycemia is a risk. The most commonly reported adverse events include nausea, vomiting, anorexia, headache, abdominal pain, fatigue, dizziness, coughing, and pharyngitis.

Chemical Properties

Pramlintide acetate is White Solid

Originator

Amylin (US)

Uses

Pramlintide acetate is an analogue of human amylin used in the treatment of insulin dependent diabetes.

brand name

Symlin (Amylin).

Pramlintide acetate Preparation Products And Raw materials

Raw materials

Preparation Products


Pramlintide acetate Suppliers

Global( 109)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
SUZHOU TIANMA PHARMA GROUP TIANJI BIO-PHARMACEUTICAL CO., LTD.
18315825527
kevin@tianmapharma.com CHINA 19 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21829 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 228 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24698 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2645 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28235 58

View Lastest Price from Pramlintide acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-09 Pramlintide acetate
196078-30-5
US $7.00 / KG 1KG 99% 100KG career henan chemical co

196078-30-5(Pramlintide acetate)Related Search:


  • AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE
  • pramlintide acetate
  • pramlintide acetate hydrate
  • Pramlintide Acetate, Amylin Rat
  • 25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate
  • AC-137 Acetate Hydrate, SyMlin Acetate Hydrate
  • Tripo-aMylin Acetate Hydrate
  • 196078-30-5
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  • C171H267N51O53S2
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  • Peptide
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  • Heterocycles
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