CP-944629
- CAS No.
- 668990-94-1
- Chemical Name:
- CP-944629
- Synonyms
- CP-944629;CP-944629 >=98% (HPLC);1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-
- CBNumber:
- CB44741671
- Molecular Formula:
- C19H15F3N4O
- Molecular Weight:
- 372.34
- MDL Number:
- MOL File:
- 668990-94-1.mol
- MSDS File:
- SDS
Last updated:2023-04-23 13:52:06
| Density | 1.39±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | room temp |
| pka | 2.70±0.50(Predicted) |
| form | powder |
| color | white to beige |
| FDA UNII | KB2ZD36HED |
CP-944629 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0238 | CP-944629 ≥98% (HPLC) | 668990-94-1 | 5mg | $114 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0238 | CP-944629 ≥98% (HPLC) | 668990-94-1 | 25mg | $434 | 2023-06-20 | Buy |
| TRC | C781598 | CP-944629 | 668990-94-1 | 500mg | $90 | 2021-12-16 | Buy |
CP-944629 Chemical Properties,Uses,Production
Biochem/physiol Actions
CP-9446219 is a potent p38alpha (p38α) inhibitor (IC50 = 1.8 nM) with no inhibitory potency against a panel of 26 other knases (IC50 >10 μM), including p38gamma (p38γ) and p38delta (p38δ), MKK1, MAPK2/ERK2, JNK, MAPKAP-K1a, and MAPKAP-K2. CP-944629 effectively inhibits LPS-stimulated cellular TNF-α production in vitro (IC50 = 63 and 8.3 nM, using human whole blood and isolated mononuclear cells, respectively) and in rats in vivo (ED50 = 0.1 mg/kg p.o.) with good pharmacokinetic profile and oral availability (F = 66%/monkey, 54%/rat).
CP-944629 Preparation Products And Raw materials
Raw materials
Preparation Products
CP-944629 Suppliers
Global( 7)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Sigma-Aldrich | 80 |
| Energy Chemical | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
CP-944629
1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-6-[4-(2,4,5-trifluorophenyl)-5-oxazolyl]-
CP-944629 >=98% (HPLC)
668990-94-1