Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
- CAS No.
- 335166-00-2
- Chemical Name:
- Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
- Synonyms
- Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
- CBNumber:
- CB44813761
- Molecular Formula:
- C19H21Br2ClFN3
- Molecular Weight:
- 505.65
- MDL Number:
- MFCD20926332
- MOL File:
- 335166-00-2.mol
Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem price More Price(2)
Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Chemical Properties,Uses,Production
Uses
iMAC2 is a mitochondrial apoptosis-induced channel (MAC) inhibitor.
General Description
A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 μM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 μM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC50 = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC50 = 2.5 μM).
storage
Desiccate at RT
Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Supplier | Advantage |
---|---|
Sigma-Aldrich | 80 |
Energy Chemical | 58 |