ChemicalBook
Chinese Japanese Germany Korea

APICIDIN

APICIDIN
APICIDIN structure
CAS No.
183506-66-3
Chemical Name:
APICIDIN
Synonyms
OSI 2040;APICIDIN;Ccris 9163;Apicidin Ia;Apicidin (OSI 2040);APICIDIN, FUSARIUM SPECIES;CYCLO-[L-(2-AMINO-8-OXODECANOYL)-L-(N-METHOXYTRYPTOPHAN)-L-ISOLEUCYL-D-PIPECOLINYL;CYCLO-L-(2-AMINO-8-OXODEACANOYL)-L-(N-METHOXY-TRYPTOPHAN)-L-ISOLEUCYL-D-PIPECOLINYL;Cyclo(8-oxo-L-2-aMinodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl- D-2-piperidinecarbonyl);Cyclo[(2S)-2-aMino-8-oxodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
CBNumber:
CB4482789
Molecular Formula:
C34H49N5O6
Formula Weight:
623.78
MOL File:
183506-66-3.mol

APICIDIN Properties

Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: ~1mg/mL
form 
solid
pka
13.09±0.70(Predicted)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300-H310-H330
Precautionary statements  P260-P264-P280-P284-P302+P350-P310
Hazard Codes  T+
Risk Statements  26/27/28
Safety Statements  22-26-36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
HS Code  29419090

APICIDIN price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A8851 Apicidin ≥98% (HPLC), from microbial 183506-66-3 1mg $113 2021-03-22 Buy
Sigma-Aldrich A8851 Apicidin ≥98% (HPLC), from microbial 183506-66-3 5mg $390 2021-03-22 Buy
Cayman Chemical 10575 Apicidin ≥90% 183506-66-3 1mg $47 2021-03-22 Buy
Cayman Chemical 10575 Apicidin ≥90% 183506-66-3 5mg $188 2021-03-22 Buy
Cayman Chemical 10575 Apicidin ≥90% 183506-66-3 10mg $353 2021-03-22 Buy

APICIDIN Chemical Properties,Uses,Production

Chemical Properties

Solid

Uses

Apicidin is a potent (nM) cell permeable inhibitor of histone deacetylase. Also, Apicidin exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin.

Uses

Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis.

Enzyme inhibitor

This fungal metabolite and potential oral chemotherapeutic agent (FW = 623.79 g/mol; CAS 183506-66-3), also known as [cyclo(N-O-methyl-L- tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)], is an antiprotozoal agent. It is cell permeable and is a strong inhibitor of histone deacetylase (IC50 = 0.7 nM). Apicidin also inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Apicidin’s low bioavailability of apicidin is mainly due to the P-gycoprotein-mediated efflux.

APICIDIN Preparation Products And Raw materials

Raw materials

Preparation Products


APICIDIN Suppliers

Global( 101)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 896 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
contact@trustwe.com CHINA 14976 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Zhejiang Huida Biotech Co., LTD
8615669048680 008613515763466
wendy@huidabiotech.com CHINA 87 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
13588875226 86-571-88216897、88216896
86-571-88216895 sales@hzclap.com CHINA 6469 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Alabiochem Tech.Co., Ltd. 13962259467 0512-58900862
0086-512-56765862 sales@alabiochem.com;sales@alabiochem.com China 998 59
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15424 60
BOC Sciences 16314854226
info@bocsci.com United States 9986 65

183506-66-3(APICIDIN)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved