BRL 50481
- CAS No.
- 433695-36-4
- Chemical Name:
- BRL 50481
- Synonyms
- -50481;BRL 50481;5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE;N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE;Benzenesulfonamide, N,N,2-trimethyl-5-nitro-;3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide
- CBNumber:
- CB4485083
- Molecular Formula:
- C9H12N2O4S
- Molecular Weight:
- 244.27
- MDL Number:
- MFCD03039912
- MOL File:
- 433695-36-4.mol
- MSDS File:
- SDS
| Melting point | 65-67°C |
|---|---|
| Boiling point | 391.1±52.0 °C(Predicted) |
| Density | 1.334±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 12 mg/mL |
| form | solid |
| pka | -5?+-.0.70(Predicted) |
| color | white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | 03G869PR3P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| HS Code | 2935.90.9500 |
BRL 50481 price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B0936 | BRL 50481 ≥98% (HPLC), solid | 433695-36-4 | 5mg | $195 | 2024-03-01 | Buy |
| Sigma-Aldrich | B0936 | BRL 50481 ≥98% (HPLC), solid | 433695-36-4 | 25mg | $610 | 2024-03-01 | Buy |
| TCI Chemical | T3112 | N,N,2-Trimethyl-5-nitrobenzenesulfonamide >98.0%(HPLC)(N) | 433695-36-4 | 200mg | $44 | 2024-03-01 | Buy |
| TCI Chemical | T3112 | N,N,2-Trimethyl-5-nitrobenzenesulfonamide >98.0%(HPLC)(N) | 433695-36-4 | 1g | $130 | 2024-03-01 | Buy |
| Alfa Aesar | J67146 | BRL-50481, 98% | 433695-36-4 | 10mg | $122 | 2021-12-16 | Buy |
BRL 50481 Chemical Properties,Uses,Production
Description
BRL-50481 (433695-36-4) is a potent and selective inhibitor of phosphodiesterase-7 (PDE7), Ki=180 nM.1?Induces apoptosis in chronic lymphocytic leukemia cells which express PDE7B.2?BRL-50481 increases mineralization in osteoblasts differentiated from hMSC.3?Cell permeable.
Chemical Properties
Off-White Solid
Uses
A PDE7 inhibitor that has acceptable selectivity for in vivo studies
Definition
ChEBI: BRL-50481 is a C-nitro compound that is benzene substituted by N,N-dimethylaminosulfonyl, methyl and nitro groups at positions 1, 2 and 5, respectively. It is a phosphodiesterase inhibitor selective for the PDE7 subtype (Ki = 180 nM). It has a role as an EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor, a geroprotector and a bone density conservation agent. It is a sulfonamide, a C-nitro compound and a member of toluenes.
Biological Activity
Selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (K i = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.
Biochem/physiol Actions
BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).
storage
Store at +4°C
References
1) Smith et al. (2004), Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages and CD8+ T-lymphocytes; Mol. Pharmacol., 66 1679 2) Zhang et al. (2008), Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia; Proc. Natl. Acad. Sci. USA 105 19532 3) Pekkinen et al. (2008), Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts; Bone 43 84
BRL 50481 Preparation Products And Raw materials
Raw materials
Preparation Products
BRL 50481 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18458 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
