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L-Lysine

L-Lysine
L-Lysine structure
CAS No.
56-87-1
Chemical Name:
L-Lysine
Synonyms
Lys;ysine;LYSINE;L-Lys-OH;L-LYSINE;H-LYS-OH;laiansuan;FEMA 3847;Aminutrin;lysineacid
CBNumber:
CB4492106
Molecular Formula:
C6H14N2O2
Formula Weight:
146.19
MOL File:
56-87-1.mol

L-Lysine Properties

Melting point:
215 °C (dec.)(lit.)
alpha 
D20 +14.6° (c = 6.5); D23 +25.9° (c = 2 in 6.0N HCl)
Boiling point:
265.81°C (rough estimate)
Density 
1.1360 (rough estimate)
FEMA 
3847 | L-LYSINE
refractive index 
26 ° (C=2, 5mol/L HCl)
storage temp. 
Store at RT.
solubility 
H2O: 0.1 g/mL, clear, colorless
pka
2.16(at 25℃)
form 
Powder or Crystals
color 
White to light yellow
optical activity
[α]20/D +26.0±1.0°, c = 2% in 6 M HCl
Water Solubility 
Soluble in water. Insoluble in ethanol, ethyl ether, acetone, benzene and common neutral solvent.
JECFA Number
1439
Merck 
14,5636
BRN 
1722531
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
KDXKERNSBIXSRK-YFKPBYRVSA-N
FDA 21 CFR
172.320; 310.545
CAS DataBase Reference
56-87-1(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
L-LYSINE
EWG's Food Scores
1
FDA UNII
K3Z4F929H6
NIST Chemistry Reference
Lysine(56-87-1)
EPA Substance Registry System
Lysine (56-87-1)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
RTECS  OL5540000
TSCA  Yes
HS Code  29224110

L-Lysine price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 23128 L-Lysine analytical standard 56-87-1 100mg $55.4 2021-03-22 Buy
Sigma-Aldrich 62840 L-Lysine crystallized, ≥98.0% (NT) 56-87-1 25g-f $108 2020-08-18 Buy
Sigma-Aldrich 62840 L-Lysine crystallized, ≥98.0% (NT) 25 g $112 2021-03-22 Buy
Sigma-Aldrich W384720 L-Lysine ≥98%, FG 100 g $150 2021-03-22 Buy
Sigma-Aldrich 62840 L-Lysine crystallized, ≥98.0% (NT) 100 g $194 2021-03-22 Buy

L-Lysine Chemical Properties,Uses,Production

Description

See ι-LYSINE MONOCHLORIDE.

Chemical Properties

L-Lysine is an essential amino acid (a protein building block) that cannot be produced by the body from other nutri ents. It helps ensure adequate absorption of calcium and the formation of collagen for bone, cartilage and connective tissue. This compound is odorless.

Chemical Properties

White to pale yellow crystalline powder

Occurrence

Some natural food sources for l-lysine include lima beans, kidney beans, potatoes, corn, red meat, fish and milk.

Uses

Essential amino acid for human development. Lysine residues are useful in many cellular processes, due to their ability to accept a wide variety of post-translational modifications.

Uses

A moderate serotonin antagonist and essential amino acid.

Uses

lysine is a skin-conditioning amino acid.

Definition

ChEBI: An L-alpha-amino acid; the L-isomer of lysine.

Preparation

Produced by fermentation. Also produced by use of continuous ion exchange technology.

Biotechnological Production

C. glutamicum and, to a lesser extent, E. coli are the main organisms used today for industrial L-lysine production. The first L-producing strains based on C. glutamicum were reported in 1961, and those based on E. coli in 1995. The advantages of using E. coli versus C. glutamicum include the achievement of higher growth rates at higher fermentation temperatures. The formation of lysine is highly influenced by two enzymes, aspartate kinase (AK) and homoserine dehydrogenase (HDH). AK converts aspartate into aspartate semialdehyde, and is highly feedback-inhibited by lysine and threonine. HDH converts aspartate semialdehyde into homoserine, which is an intermediate for the biosynthesis of threonine, methionine, and isoleucine. L-Lysine–producing strains therefore often contain a deregulated AK and/or a reduced activity HDH. Despite the improvement of the flux from aspartate towards lysine, the availability of key metabolites from the central metabolic pathways is also essential. Here the formation of oxaloacetate directly from phosphoenol pyruvate or via pyruvate is essential for the carbon yield as some unnecessary cycles are included. For example, inactivation of the enzyme phosphoenol pyruvate carboxykinase, which catalyzes the reverse reaction from oxaloacetate to phosphoenol pyruvate gave an improvement in lysine formation. By overexpression of pyruvate carboxylase, the conversion yield of glucose to lysine could be increased by 50 %. With a synthetic lysine hyperproducing strain, containing 12 defined modifications from the wild type, a carbon yield of 0.55 g/g and a product titer of 120 g/L over 30 h fermentation could be obtained.
Today, however, the main commercial process for L-lysine remains the fermentation of C. glutamicum. This is performed in fed-batch mode in large-scale fermenters of up to 500 m3 volume, with production capacities in excess of 100,000 tonnes. The commercial manufacturing process has been comprehensively described by Pfefferle.

Aroma threshold values

Detection: 500 ppm

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 3161, 1949 DOI: 10.1021/ja01177a063

Safety Profile

An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Lysine may be effective in suppressing FHV-1 infections in cats.

Purification Methods

Crystallise L-lysine from aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2097-2122 1961, Kearley & Ingersoll J Am Chem Soc 73 5783 1951, Beilstein 4 IV 2717.]

L-Lysine Preparation Products And Raw materials

Raw materials

Preparation Products


L-Lysine Suppliers

Global( 509)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21484 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22608 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2813 55
Hebei Chisure Biotechnology Co.LTD
13292891350 +86 13292890173
luna@speedgainpharma.com CHINA 1010 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29988 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58

View Lastest Price from L-Lysine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-06-19 L-Lysine
56-87-1
US $0.00 / Kg/Drum 1KG 98%min 20 TONS WUHAN FORTUNA CHEMICAL CO., LTD
2020-10-20 L-Lysine
56-87-1
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-06-07 L-Lysine
56-87-1
US $41.00 / KG 1KG 99% 10 tons Baoji Guokang Bio-Technology Co., Ltd.

L-Lysine Spectrum


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