1,3-Thiazole-2-carbaldehyde
- CAS No.
- 10200-59-6
- Chemical Name:
- 1,3-Thiazole-2-carbaldehyde
- Synonyms
- THIAZOLE-2-CARBALDEHYDE;20:5n3);EOS-61959;2-FORMYLTHIAZOLE;2-Formylthiazole>2-Formyl-1,3-thiazole;2-Thiazolecarbaldehyde;thiazol-2-carbaldehyde;eicosapentaenoate (EPA;2-THIAZOLECARBOXALDEHYDE
- CBNumber:
- CB4493103
- Molecular Formula:
- C4H3NOS
- Molecular Weight:
- 113.14
- MDL Number:
- MFCD00142924
- MOL File:
- 10200-59-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Thiazolecarboxaldehyde 97% | 422460 | 1g | $81.79 |
| 2-Formylthiazole >97.0%(GC) | F0303 | 1g | $39 |
| 2-Formylthiazole >97.0%(GC) | F0303 | 5g | $127 |
| 2-Thiazolecarboxaldehyde 97% | JK613181 | 1g | $98 |
| Thiazole-2-carboxaldehyde 98% | 069072 | 25g | $119 |
| More product size | |||
| Boiling point | 61-63 °C/15 mmHg (lit.) |
|---|---|
| Density | 1.288 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 154 °F |
| storage temp. | 2-8°C |
| pka | 0.44±0.10(Predicted) |
| form | Liquid |
| color | Colorless to pale yellow |
| Water Solubility | soluble |
| InChI | InChI=1S/C4H3NOS/c6-3-4-5-1-2-7-4/h1-3H |
| InChIKey | ZGTFNNUASMWGTM-UHFFFAOYSA-N |
| SMILES | S1C=CN=C1C=O |
| LogP | 0.602 (est) |
| CAS DataBase Reference | 10200-59-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P280-P403+P235-P501-P210e-P261-P280a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 36/37/39-26-23-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
1,3-Thiazole-2-carbaldehyde price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 422460 | 2-Thiazolecarboxaldehyde 97% | 10200-59-6 | 1g | $81.79 | 2025-07-31 | Buy |
| TCI Chemical | F0303 | 2-Formylthiazole >97.0%(GC) | 10200-59-6 | 1g | $39 | 2025-07-31 | Buy |
| TCI Chemical | F0303 | 2-Formylthiazole >97.0%(GC) | 10200-59-6 | 5g | $127 | 2025-07-31 | Buy |
| Frontier Specialty Chemicals | JK613181 | 2-Thiazolecarboxaldehyde 97% | 10200-59-6 | 1g | $98 | 2021-12-16 | Buy |
| Matrix Scientific | 069072 | Thiazole-2-carboxaldehyde 98% | 10200-59-6 | 25g | $119 | 2021-12-16 | Buy |
1,3-Thiazole-2-carbaldehyde Chemical Properties,Uses,Production
Chemical Properties
Colorless to light yellow liqui
Uses
2-Thiazolecarboxaldehyde is a useful building block for taxane analogs.
Synthesis Reference(s)
Synthesis, p. 998, 1987 DOI: 10.1055/s-1987-28146
General Description
2-Thiazolecarboxaldehyde is a thiazole aldehyde derivative. It undergoes Baylis–Hillman reaction with methyl acrylate catalyzed by DABCO (1,4-diazabicyclo[2.2.2]octane). The reaction mechanism has been studied by electrospray ionization mass spectrometry (ESI-MS).
Synthesis
3034-53-5
68-12-2
10200-59-6
General procedure for the synthesis of 2-formylthiazole from 2-bromothiazole and N,N-dimethylformamide: An ether (43 mL) solution of 2-bromothiazole (10.00 g, 60.96 mmol) was added dropwise to a cooled solvate over a period of 1 hr at -78°C. Subsequently, 1.6 M butyl lithium (46 mL, 73.5 mmol) in hexane was added. The resulting mixture was stirred at -70 °C for 20 min, and then N,N-dimethylformamide (7.50 mL, 97.5 mmol) was added over 1 h while keeping the temperature below -65 °C. The reaction was carried out at -65 °C. The reaction mixture was warmed to -40°C over 1 hr and stirring was continued at this temperature for 1 hr. The reaction mixture was slowly warmed to 0 °C and quenched with 4 M aqueous hydrochloric acid. The organic and aqueous layers were separated. The organic layer was washed with 4M aqueous hydrochloric acid solution and discarded. The combined aqueous layers were neutralized with potassium carbonate and extracted with ether (3 times). The combined organic extracts were dried over magnesium sulfate, filtered, and the solvent was removed in vacuum to give 2-formylthiazole (6.88 g, 99% yield) as a brown oil, which did not require further purification.
References
[1] Patent: WO2006/92268, 2006, A1. Location in patent: Page/Page column 22
[2] Journal of Organic Chemistry, 1995, vol. 60, # 15, p. 4749 - 4754
[3] Patent: US5512575, 1996, A
[4] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007, vol. 62, # 12, p. 1525 - 1529
[5] Patent: WO2018/108125, 2018, A1. Location in patent: Paragraph 00539
1,3-Thiazole-2-carbaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5242 | 58 |
| Sach biotech Co.,Ltd | +8615888865902 | sales@hzsqchem.com | China | 63 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29837 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
View Lastest Price from 1,3-Thiazole-2-carbaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-06 | 1,3-Thiazole-2-carbaldehyde
10200-59-6
|
US $768.00-15000.00 / kg | 1kg | 99% | 10mt | Sach biotech Co.,Ltd | |
 |
2025-05-26 | 1,3-Thiazole-2-carbaldehyde
10200-59-6
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2024-07-23 | 1,3-Thiazole-2-carbaldehyde
10200-59-6
|
US $0.00-0.00 / kg | 1kg | 99% | 10ton | JINING XINHE CHEMICAL CO., LTD |
-
- 1,3-Thiazole-2-carbaldehyde
10200-59-6
- US $768.00-15000.00 / kg
- 99%
- Sach biotech Co.,Ltd
-
- 1,3-Thiazole-2-carbaldehyde
10200-59-6
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 1,3-Thiazole-2-carbaldehyde
10200-59-6
- US $0.00-0.00 / kg
- 99%
- JINING XINHE CHEMICAL CO., LTD
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