ChemicalBook >> CAS DataBase List >>Chloropyramine hydrochloride

Chloropyramine hydrochloride

CAS No.
6170-42-9
Chemical Name:
Chloropyramine hydrochloride
Synonyms
CHLOROPYRAMINE HCL;Chloropyramine HCI;Nilfan;Alergosan;Halopyramine hydrochloride;CHLOROPYRAMINE HYDROCHLORIDE;CHLOROPYRAMINE MONOHYDROCHLORIDE;Chloropyramine hydrochloride salt;3-chloro-2H-pyran-2-amine hydrochloride;N-P-CHLOROBENZYL-N,N-DIMETHYL-N-(2-PYRIDYL)ETHYLENEDIAMINE HYDROCHLORIDE
CBNumber:
CB4495475
Molecular Formula:
C16H21Cl2N3
Molecular Weight:
326.26
MDL Number:
MFCD00079009
MOL File:
6170-42-9.mol
Last updated:2023-12-22 17:53:22

Chloropyramine hydrochloride Properties

Melting point 172-174°
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
color White to Off-White
CAS DataBase Reference 6170-42-9(CAS DataBase Reference)
FDA UNII FWA92Z14NN

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
WGK Germany  3

Chloropyramine hydrochloride price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C1915 Chloropyramine hydrochloride analytical standard, for drug analysis 6170-42-9 1g $14.4 2024-03-01 Buy
Alfa Aesar J60350 Chloropyramine hydrochloride 6170-42-9 1g $32.65 2024-03-01 Buy
TRC C381268 Chloropyramine hydrochloride 6170-42-9 1g $125 2021-12-16 Buy
American Custom Chemicals Corporation API0001961 CHLOROPYRAMINE HYDROCHLORIDE 95.00% 6170-42-9 1G $131.25 2021-12-16 Buy
Biosynth Carbosynth FC149051 Chloropyramine HCl 6170-42-9 5G $150 2021-12-16 Buy
Product number Packaging Price Buy
C1915 1g $14.4 Buy
J60350 1g $32.65 Buy
C381268 1g $125 Buy
API0001961 1G $131.25 Buy
FC149051 5G $150 Buy

Chloropyramine hydrochloride Chemical Properties,Uses,Production

Originator

Chloropyramine,Vramed

Uses

synthetic

Uses

Chloropyramine hydrochloride is a neurotransmitter related agent for research of drug analysis. Also, it is designed to disrupt the focal adhesion kinase (FAK) and vascular endothelial growth factor receptor-3 (VEGFR-3) interaction in neuroblastoma.

Manufacturing Process

A solution comprising 40 parts of 2-bromopyridine, 100 parts of N,N-dimethylN'-(4-chlorobenzyl)ethylenediamine and 100 parts of quinoline is heated at 140-145°C for 5 hours. The oil layer after washing with 30% sodium hydroxide solution is distilled, and the fraction which distills at 142-170°C/1 mm is collected. This oil is converted to the monohydrochloride and recrystallized from a mixture of amyl alcohol and ether. The monohydrochloride salt of N,N-dimethyl-N'-(4-chlorobenzyl)-N'-(2-pyridyl) ethylenediamine is obtained which melts at 167-168.4°C.
N,N-Dimethyl-N'-(4-chlorobenzyl)-N'-(2-pyridyl)ethylenediamine may be prepared by another method:
To a mixture of 100 ml of liquid ammonia and about 80 mg of black iron oxide was added 0.78 g (0.02 atom) of potassium. When all of the potassium had reacted, 3.3 g of N,N-dimethyl-N'-(2-pyridyl)ethylenediamine was added. After the addition of 75 ml of dry toluene the ammonia was removed on the steam bath. To the cooled and stirred mixture was added 4.26 g of p-chlorobenzyl chloride, and the reaction mixture was stirred on the steam bath for 11 hours. It was then filtered and concentrated to an oil. This concentrate was taken up in ether, and the ethereal solution was washed with water, dried over sodium sulfate, and concentrated. Distillation gave 2.96 g of yellow liquid. Treatment of this distillate with an equivalent quantity of hydrogen chloride in absolute alcohol and precipitation by the addition of anhydrous ether gave 2.33 g of the N,N-dimethyl-N'-(4-chlorobenzyl)-N'-(2-pyridyl)ethylenediamine hydrochloride.

Therapeutic Function

Antihistaminic

Chloropyramine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 92)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 5085 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
Alfa Chemistry
+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Hebei Duling International Trade Co. LTD
+8618032673083 sales05@hbduling.cn China 15755 58

View Lastest Price from Chloropyramine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chloropyramine hydrochloride pictures 2023-12-23 Chloropyramine hydrochloride
6170-42-9
US $50.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
Chloropyramine hydrochloride pictures 2020-01-13 Chloropyramine hydrochloride
6170-42-9
US $1.00 / KG 1KG 99% 100KG Career Henan Chemical Co

Chloropyramine hydrochloride Spectrum

CHLOROPYRAMINE HYDROCHLORIDE CHLOROPYRAMINE MONOHYDROCHLORIDE N-P-CHLOROBENZYL-N,N-DIMETHYL-N-(2-PYRIDYL)ETHYLENEDIAMINE HYDROCHLORIDE N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]ETHYLENEDIAMINE HYDROCHLORIDE N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]LETHYLENEDIAMINE HYDROCHLORIDE N1-(4-Chlorobenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine hydrochloride N-[(4-chlorophenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-1,2-ethanediamine 3-chloro-2H-pyran-2-amine hydrochloride Chloropyramine hydrochloride salt Nilfan Halopyramine hydrochloride Alergosan CHLOROPYRAMINE HCL Chloropyramine HCI Vascular endothelial growth factor receptor,FAK,inhibit,PTK2,Chloropyramine hydrochloride,VEGFR,Chloropyramine,Focal adhesion kinase,PTK2 protein tyrosine kinase 2,Histamine Receptor,Inhibitor N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine,hydrochloride 6170-42-9 C16H20ClN3HCl C16H20ClN3ClH Alphabetic Analytical Chromatography Product Catalog Analytical Standards CH