PB28 DIHYDROCHLORIDE
- CAS No.
- 172907-03-8
- Chemical Name:
- PB28 DIHYDROCHLORIDE
- Synonyms
- PB 28 hydrochloride;PB28 dihydrochloride,PB-28 dihydrochloride
- CBNumber:
- CB4497464
- Molecular Formula:
- C14H17Cl2N3O3
- Molecular Weight:
- 346.20908
- MDL Number:
- MOL File:
- 172907-03-8.mol
| storage temp. | -20°C |
|---|---|
| solubility | Soluble in DMSO (>25 mg/ml) or water (5 mg/ml) |
| form | solid |
| color | White to off-white |
| Water Solubility | Soluble to 20 mM in water with gentle warming |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| NFPA 704 |
|
PB28 DIHYDROCHLORIDE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | B7107 | PB28 dihydrochloride | 172907-03-8 | 10mg | $234 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004727 | PB-28 HYDROCHLORIDE 95.00% | 172907-03-8 | 10MG | $733.72 | 2021-12-16 | Buy |
| ApexBio Technology | B7107 | PB28 dihydrochloride | 172907-03-8 | 50mg | $975 | 2021-12-16 | Buy |
PB28 DIHYDROCHLORIDE Chemical Properties,Uses,Production
Description
PB28 (172907-03-8) is a very potent high affinity (Ki = 5.3 nM1, 0.34 nM2) σ2 agonist.? Selective for σ2 over σ1 (approx 30-40x).1,2 PB28 inhibited cell growth in MCF7 and MCF7 ADR breast cancer cells and displayed strong synergism with doxorubicin.3? PB28 potently inhibited Kv2.1 currents in a σ-independent manner.4 PB28 was recently found to have potent (IC50 = 280 nM) anti-SARS-CoV2 activity.5
storage
Desiccate at +4°C
References
Berardi et al. (1996), New s and 5-HT1A Receptor Ligands: w-(Tetralin-1-yl)-n-alkylamine Derivatives; J. Med. Chem. 39 176 Berardi et al. (2004), 4-(Tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl Derivatives of 1-Cyclohexylpiperazine as s Receptor Ligands with Agonist s2 Activity; J. Med. Chem. 47 2308 Azzariti et al. (2006), Cyclohexylpiperazine derivative PB28, a s2 agonist and s1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclins in breast cancer; Cancer Ther. 5 1807 Liu et al. (2017), Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel; Oncotarget 8 59345 Gordon et al. (2020), A SARS-CoV-2 protein interaction map reveals targets for drug repurposing; Nature 583 459
PB28 DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
PB28 DIHYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24024 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2490 | 58 |