Ibandronic acid
- CAS No.
- 114084-78-5
- Chemical Name:
- Ibandronic acid
- Synonyms
- Ibandronic;BPH 24;Ibadronic Acid;Ibandronic acid;Ibandronate Acid;IBANDRONIC ACID-D3;Tirofiban Impurity 67;Ibandronic acid USP/EP/BP;[1-Hydroxy-3-(MethylpentylaMino)propylidene]diphosphonic Acid;{1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphnic Acid
- CBNumber:
- CB4500836
- Molecular Formula:
- C9H23NO7P2
- Molecular Weight:
- 319.23
- MDL Number:
- MFCD00868772
- MOL File:
- 114084-78-5.mol
- MSDS File:
- SDS
| Melting point | 113-115°C |
|---|---|
| Boiling point | 587.8±60.0 °C(Predicted) |
| Density | 1.449±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly) |
| pka | 1.60±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| CAS DataBase Reference | 114084-78-5(CAS DataBase Reference) |
| FDA UNII | UMD7G2653W |
| ATC code | M05BA06 |
| EPA Substance Registry System | Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis- (114084-78-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Ibandronic acid price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | I120000 | IbandronicAcid | 114084-78-5 | 25mg | $80 | 2021-12-16 | Buy |
| Usbiological | I0425 | Ibandronic Acid | 114084-78-5 | 100mg | $403 | 2021-12-16 | Buy |
| Usbiological | 014694 | Ibandronic Acid-d3 | 114084-78-5 | 2.5mg | $425 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | D11082 | IbandronicAcid-d3 | 114084-78-5 | 1mg | $875 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | D11082 | IbandronicAcid-d3 | 114084-78-5 | 10mg | $2000 | 2021-12-16 | Buy |
Ibandronic acid Chemical Properties,Uses,Production
Description
This third generation biphosphonate was launched in Austria and Germany for the treatment of bone disorders such as hypercalcemia in malignancy and ostedysis, Paget's disease and osteoporosis. It does not effect bone mineralization, therefore, the potential risk of osteomalacia is prevented. This was a problem with first generation derivatives. While the exact mode of action is not understood, they are inhibitors of osteroclast mediated bone resorption. These compounds strongly interact with hydroxyapatite crystals and have a half-life in the skeleton of several years. Despite this observation ibandronate was well tolerated and safe.
Chemical Properties
White Solid
Originator
Boehringer Mannheim (Germany)
Uses
A labeled biphosphonate bone resorption inhibitor.
Uses
Labelled Ibandronic Acid (I120000). A bisphosphonate antiresorptive agent. Bone resorption inhibitor.
Uses
A bisphosphonate antiresorptive agent. Bone resorption inhibitor.
Uses
A biphosphonate bone resorption inhibitor.
brand name
Bondronat
Clinical Use
Bisphosphonate:
Reduction of bone damage in bone metastases in
breast cancer
Hypercalcaemia of malignancy
Postmenopausal osteoporosis
Metabolism
After initial systemic exposure, ibandronic acid rapidly binds to bone or is excreted into urine. There is no evidence that ibandronic acid is metabolised in animals or humans. The absorbed fraction of ibandronic acid is removed from the circulation via bone absorption (estimated to be 40-50% in postmenopausal women) and the remainder is eliminated unchanged by the kidney. The unabsorbed fraction of ibandronic acid is eliminated unchanged in the faeces. Renal clearance accounts for 50-60% of total clearance and is related to creatinine clearance. The difference between the apparent total and renal clearances is considered to reflect the uptake by bone.
Ibandronic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
View Lastest Price from Ibandronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-22 | Ibandronic acid
114084-78-5
|
US $25.00 / kg | 1kg | 99% | 5000 tons | Hebei Duling International Trade Co. LTD | |
 |
2021-11-03 | Ibandronic acid
114084-78-5
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2021-07-29 | Ibandronic acid USP/EP/BP
114084-78-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Ibandronic acid
114084-78-5
- US $25.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- Ibandronic acid
114084-78-5
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- Ibandronic acid USP/EP/BP
114084-78-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited