IC86621
- CAS No.
- 404009-40-1
- Chemical Name:
- IC86621
- Synonyms
- IC 86621 (IC86621);IC86621 CAS#: 404009-40-1;1-(2-hydroxy-4-Morpholinophenyl)ethanone;1-(2-Hydroxy-4-morpholinophenyl)ethan-1-one;Ethanone, 1-[2-hydroxy-4-(4-morpholinyl)phenyl]-;DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem;ATP,Buchwald-Hartwig amination,Inhibitor,IC-86621,IC86621,IC 86621,DSB,antitumor,inhibit,Apoptosis,Fries rearrangement,DNA-dependent protein kinase,DNA-PK
- CBNumber:
- CB4503635
- Molecular Formula:
- C12H15NO3
- Molecular Weight:
- 221.25
- MDL Number:
- MFCD07370140
- MOL File:
- 404009-40-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| WGK Germany | 3 |
IC86621 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 260962 | DNA-PK Inhibitor III | 404009-40-1 | 1mg | $154 | 2023-01-07 | Buy |
| TRC | H852750 | 1-(2-Hydroxy-4-morpholinophenyl)ethanone | 404009-40-1 | 10mg | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0073228 | 1-(2-HYDROXY-4-MORPHOLINOPHENYL)ETHANONE 95.00% | 404009-40-1 | 100MG | $824.19 | 2021-12-16 | Buy |
| AK Scientific | 4512AH | 1-(2-Hydroxy-4-morpholinophenyl)ethanone | 404009-40-1 | 250mg | $428 | 2021-12-16 | Buy |
| Chemenu | CM314918 | 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone 95% | 404009-40-1 | 1g | $571 | 2021-12-16 | Buy |
IC86621 Chemical Properties,Uses,Production
Definition
ChEBI: 1-[2-hydroxy-4-(4-morpholinyl)phenyl]ethanone is an aromatic ketone.
General Description
A cell-permeable aryl-morpholino compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 120 nM) and PI 3-Kinase catalytic subunit p110β (IC50 = 135 nM). It inhibits DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC50 = 68 μM) and enhances DSB-induced antitumor activity both in vitro and in vivo, while exhibiting no cytotoxic effects (up to 50 μM) in the absence of DSBs. It inhibits PI 3-K p110α, p110γ, and p110δ only at much higher concentrations (IC50 = 1.4, 0.88, and 1.0 μM, respectively) and exhibits no effect against a panel of several other kinases, including, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12, even at concentrations as high as 100 μM.
Biochem/physiol Actions
Cell permeable: yes
IC86621 Preparation Products And Raw materials
Raw materials
Preparation Products
IC86621 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| SanoChem (Chengdu) Tech. Co., Ltd. | 28-87999436 02887999436 | sales@sano-chem.com | China | 3929 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9374 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-66110311 13155353615 | qzhang@aikonchem.com | China | 15527 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |