Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Structure
(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one structure
CAS No.
2375482-51-0
Chemical Name:
(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one
Synonyms
BI-2852;BI-2852,Ras,inhibit,BI 2852,Inhibitor,BI2852;(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one;1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-3-[2-[[[[1-[(1-methyl-1H-imidazol-4-yl)methyl]-1H-indol-6-yl]methyl]amino]methyl]-1H-indol-3-yl]-, (3S)-
CBNumber:
CB45430811
Molecular Formula:
C31H28N6O2
Molecular Weight:
516.59
MDL Number:
MOL File:
2375482-51-0.mol
Last updated:2023-09-04 15:51:00
Request For Quotation

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Properties

Boiling point 906.5±65.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:77.5(Max Conc. mg/mL);150.02(Max Conc. mM)
Ethanol:23.0(Max Conc. mg/mL);44.52(Max Conc. mM)
pka 8.95±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3126 BI-2852 ≥98% (HPLC) 2375482-51-0 5MG $337 2024-03-01 Buy
Sigma-Aldrich SML3126 BI-2852 ≥98% (HPLC) 2375482-51-0 25MG $1340 2024-03-01 Buy
ChemScene CS-0100975 BI-2852 98.74% 2375482-51-0 50mg $1650 2021-12-16 Buy
ChemScene CS-0100975 BI-2852 98.74% 2375482-51-0 100mg $2900 2021-12-16 Buy
ChemScene CS-0100975 BI-2852 98.74% 2375482-51-0 5mg $350 2021-12-16 Buy
Product number Packaging Price Buy
SML3126 5MG $337 Buy
SML3126 25MG $1340 Buy
CS-0100975 50mg $1650 Buy
CS-0100975 100mg $2900 Buy
CS-0100975 5mg $350 Buy

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Chemical Properties,Uses,Production

Biological Activity

BI-2852 is a switch SI/II pocket KRAS inhibitor with nanomolar affinity through structure-based drug design. It is mechanistically distinct from covalent KRASG12C inhibitors (binding switch II), binding to active KRASG12D 10-fold more strongly than KRAS wt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP and effector interactions with KRAS, resulting in inhibition of downstream signaling and antiproliferative effects in KRAS mutant cells.

in vitro

BI-2852 (Compound 1) (10 nM-10 μM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC 50 s of 5.8 μM and 6.7 μM in soft agar and low serum conditions in NCI-H358 cells.

target

KRAS(G12C)

450 nM (IC 50 )

KRAS(G12C)

< p> 750 nM (Kd)

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Suppliers

Global( 33)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323967 +86-18015559028 sales1@artkmedchem.com China 39009 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6010 61
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3423 58
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618 sales@adobechem.com China 1250 50
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4182 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Chembest Research Laboratories Limited 61
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai YuanQi Biotechnology Co., Ltd. 50
Shanghai Lollane Biological Technology Co.,Ltd. 55
ShangHai Biochempartner Co.,Ltd 62

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one Spectrum

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one(2375482-51-0)1HNMR

2375482-51-0((S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one)Related Search:

DEMETON S METHYLERGONOVINE
(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one BI-2852 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-3-[2-[[[[1-[(1-methyl-1H-imidazol-4-yl)methyl]-1H-indol-6-yl]methyl]amino]methyl]-1H-indol-3-yl]-, (3S)- BI-2852,Ras,inhibit,BI 2852,Inhibitor,BI2852 2375482-51-0