IACS-8779
- CAS No.
- 2243079-26-5
- Chemical Name:
- IACS-8779
- Synonyms
- IACS-8779;IACS8779,IACS 8779;(1R,3R,6R,8R,9R,10S,12R,15R,17R)-8-{4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-17-(6-amino-9H-purin-9-yl)-9,18-dihydroxy-3,12-disulfanyl-2,4,7,11,13,16-hexaoxa-3λ?,12λ?-diphosphatricyclo[13.2.1.0?,1?]octadecane-3,12-dione
- CBNumber:
- CB45821396
- Molecular Formula:
- C21H25N9O10P2S2
- Molecular Weight:
- 689.55
- MDL Number:
- MFCD32263427
- MOL File:
- 2243079-26-5.mol
IACS-8779 Chemical Properties,Uses,Production
Uses
IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy[1].
in vivo
Mice are implanted bilaterally with B16-Ova, and IACS-8779 (compound 1a) is administered at 10 μg dose with three intra-tumoral injections, on one flank only, on day 6, 9, 12 post implantation. While IACS-8779 shows comparable antitumor activity on the injected flank, IACS-8779 achieves superior regression on the untreated tumor in the contralateral flank, suggesting a more significant systemic immune response compared to the benchmark analogs. Treatment with IACS-8779 also results in a higher number of mice cured of both tumors compared to benchmarks[1].
References
[1] Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640. DOI:10.1016/j.bmcl.2019.126640
IACS-8779 Preparation Products And Raw materials
Raw materials
Preparation Products
IACS-8779 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4757 | 55 | |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2740 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
