Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>JBJ-04-125-02

JBJ-04-125-02

JBJ-04-125-02 Structure
JBJ-04-125-02 structure
CAS No.
2060610-53-7
Chemical Name:
JBJ-04-125-02
Synonyms
JBJ-04-125-02 R-isomer;JBJ0412502,JBJ 04 125 02;(R)-2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide;2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-6-[4-(1-piperazinyl)phenyl]-N-2-thiazolyl-, (αR)-;(2R)-2-(5-Fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide
CBNumber:
CB46199845
Molecular Formula:
C29H26FN5O3S
Molecular Weight:
543.62
MDL Number:
MFCD33029239
MOL File:
2060610-53-7.mol
Last updated:2025-10-28 16:00:23
Product description Number Pack Size Price
JBJ-04-125-02 CS-0114212 5mg $600
JBJ-04-125-02 CS-0114212 10mg $880
JBJ-04-125-02 CS-0114212 50mg $2350
JBJ-04-125-02 CS-0114212 100mg $3800
Request For Quotation

JBJ-04-125-02 Properties

Density 1.424±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 7.24±0.50(Predicted)

JBJ-04-125-02 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0114212 JBJ-04-125-02 2060610-53-7 5mg $600 2021-12-16 Buy
ChemScene CS-0114212 JBJ-04-125-02 2060610-53-7 10mg $880 2021-12-16 Buy
ChemScene CS-0114212 JBJ-04-125-02 2060610-53-7 50mg $2350 2021-12-16 Buy
ChemScene CS-0114212 JBJ-04-125-02 2060610-53-7 100mg $3800 2021-12-16 Buy
Product number Packaging Price Buy
CS-0114212 5mg $600 Buy
CS-0114212 10mg $880 Buy
CS-0114212 50mg $2350 Buy
CS-0114212 100mg $3800 Buy

JBJ-04-125-02 Chemical Properties,Uses,Production

Uses

JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M. JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling. JBJ-04-125-02 has anti-tumor activities[1].

in vivo

JBJ-04-125-02 (50 mg/kg; oral gavage; once daily; for 15 weeks; EGFRL858R/T790M/C797S genetically engineered mice) treatment leads to marked tumor regressions within 4 weeks of treatment[1].
JBJ-04-125-02 exhibits a moderate half-life of 3 hours and a high area under curve of 728,577 min?ng/mL (AUClast) following 3 mg/kg intravenous (i.v.) dose. A 20 mg/kg oral dose of JBJ-04-125-02 achieves an average maximal plasma concentration of 1.1 μmol/L with an oral bioavailability of 3%[1].

Animal Model:EGFRL858R/T790M/C797S genetically engineered mice (GEM)[1]
Dosage:50 mg/kg
Administration:Oral gavage; once daily; for 15 weeks
Result:Led to marked tumor regressions within 4 weeks of treatment.

IC 50

EGFR (L858R/T790M): 0.26 nM (IC50)

References

[1] To C, et al. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 Jul;9(7):926-943. DOI:10.1158/2159-8290.CD-18-0903

JBJ-04-125-02 Preparation Products And Raw materials

Raw materials

Preparation Products

JBJ-04-125-02 Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19962 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3506 58
ShangHai Angti Biotechnology Co., Ltd. 13764913901 info@angtibio.com China 4986 55
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 3934 58
Chengdu Peter-like Biotechnology Co., Ltd. 18108052721 2850505130@qq.com China 5167 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4989 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
ShangHai Angti Biotechnology Co., Ltd. 55
Changzhou Chenhong Biotechnology Co., Ltd. 58
Chengdu Peter-like Biotechnology Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58

View Lastest Price from JBJ-04-125-02 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JBJ-04-125-02 pictures 2025-10-27 JBJ-04-125-02
2060610-53-7
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
JBJ-04-125-02 pictures 2025-08-22 JBJ-04-125-02
2060610-53-7
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
  • JBJ-04-125-02 pictures
  • JBJ-04-125-02
    2060610-53-7
  • US $2500.00-1520.00 / mg
  • TargetMol Chemicals Inc.
  • JBJ-04-125-02 pictures
  • JBJ-04-125-02
    2060610-53-7
  • US $2500.00-1520.00 / mg
  • TargetMol Chemicals Inc.
JBJ-04-125-02 R-isomer 2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-6-[4-(1-piperazinyl)phenyl]-N-2-thiazolyl-, (αR)- JBJ0412502,JBJ 04 125 02 (R)-2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide (2R)-2-(5-Fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide 2060610-53-7