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Betulinic acid

Betulinic acid
Betulinic acid structure
CAS No.
472-15-1
Chemical Name:
Betulinic acid
Synonyms
MAIRIN;ALS-357;Platanol;Betulinic;Ccris 6748;Nsc 113090;Nsc 677578;Gratiolone;Melaleucin;Betulinic a
CBNumber:
CB4667160
Molecular Formula:
C30H48O3
Formula Weight:
456.71
MOL File:
472-15-1.mol

Betulinic acid Properties

Melting point:
295-298 °C (dec.) (lit.)
alpha 
D25 +7.5° (c = 0.37 in pyridine)
Boiling point:
550.0±33.0 °C(Predicted)
Density 
1.065±0.06 g/cm3(Predicted)
refractive index 
7.8 ° (C=0.9, Pyridine)
storage temp. 
2-8°C
pka
4.61±0.70(Predicted)
form 
neat
optical activity
[α]20/D +7.8°, c = 0.9 in pyridine
Merck 
14,1190
InChIKey
QGJZLNKBHJESQX-FZFNOLFKSA-N
CAS DataBase Reference
472-15-1(CAS DataBase Reference)
FDA UNII
4G6A18707N
NCI Drug Dictionary
betulinic acid
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
HS Code  29181985

Betulinic acid price More Price(73)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 855057 Betulinic acid technical grade, 90% 472-15-1 100mg $102 2021-12-16 Buy
Sigma-Aldrich 855057 Betulinic acid technical grade, 90% 472-15-1 500mg $352 2021-12-16 Buy
TCI Chemical B2836 Betulinic Acid >97.0%(GC)(T) 472-15-1 1g $580 2021-12-16 Buy
TCI Chemical B2836 Betulinic Acid >97.0%(GC)(T) 472-15-1 100mg $125 2021-12-16 Buy
Cayman Chemical 11686 Betulinic Acid ≥97% 472-15-1 50mg $28 2021-12-16 Buy

Betulinic acid Chemical Properties,Uses,Production

Chemical Properties

colorless Needles

Uses

antineoplastic

Uses

Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activati ng the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity

Uses

Betulinic acid (BetA) has been used:
  • to test its effects as an antiviral agent against Dengue virus (DENV)
  • as a sterol regulatory element-binding protein (SREBP) inhibitor to repress the lipid metabolism and proliferation of clear cell renal cell carcinoma (ccRCC) cells
  • as a treatment to test its anti-tumor properties for cell viability and apoptotic cell death assays in multiple myeloma models

Definition

ChEBI: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium cla iflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.

General Description

Betulinic acid is a lupane-type triterpene, which can be prepared from betulin via oxidation using chromium oxide (VI). Along with anti-HIV-1 and anti-tumor activity, it also shows other bioactivities such as anti-inflammatory, antibacterial, in vitro antimalarial, anthelmintic and antioxidant activities.

Biological Activity

Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF- κ B. Exhibits TRG5 agonist activity (EC 50 = 1.04 μ M).

Biochem/physiol Actions

Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism.

Anticancer Research

This compound is a pentacyclic triterpene obtained from Betula and Zizyphus species,which shows selective cytotoxicity against human melanoma cells (Shoeb2006). It generates reactive oxygen species, activates MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates the activity of aminopeptidase-N, and thereby inducesapoptosis in cancer cells (Desai et al. 2008; Fulda 2008).

Betulinic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Betulinic acid Suppliers

Global( 347)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Aktin Chemicals, Inc.
028-85159085
86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15424 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9128 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com China 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58

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View Lastest Price from Betulinic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-14 Betulinic acid
472-15-1
US $50.00 / ASSAYS 1ASSAYS 99% 500ton Shanghai Yunao International Trade Co., Ltd
2021-12-17 Betulinic Acid
472-15-1
US $10.00 / KG 1KG 99%HPLC,USP Standard 800KGs ZhenYiBio Technology Inc
2021-11-30 Betulinic acid
472-15-1
US $15.60 / KG 1KG 99% 100kg Baoji Guokang Bio-Technology Co., Ltd.

Betulinic acid Spectrum


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