5-METHOXYFLAVONE
- CAS No.
- 42079-78-7
- Chemical Name:
- 5-METHOXYFLAVONE
- Synonyms
- 5-METHOXYFLAVONE;METHOXYFLAVONE, 5-;5-Methoxyflavone>5-Methoxy flavonone;5-Methoxyflavone,97%;5-methoxy-2-phenyl-chromone;5-methoxy-2-phenylchromen-4-one;5-methoxy-2-phenyl-4-benzopyrone;5-methoxy-2-phenyl-chromen-4-one;5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
- CBNumber:
- CB4688875
- Molecular Formula:
- C16H12O3
- Molecular Weight:
- 252.26
- MDL Number:
- MFCD00016942
- MOL File:
- 42079-78-7.mol
| Melting point | 131-133°C |
|---|---|
| Boiling point | 422.5±45.0 °C(Predicted) |
| Density | 1,155g/cm |
| refractive index | 1,548 |
| storage temp. | Store at -20°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | White to Almost white |
| LogP | 3.470 (est) |
| CAS DataBase Reference | 42079-78-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2932.99.7000 | |||||||||
| NFPA 704 |
|
5-METHOXYFLAVONE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2365 | 5-Methoxyflavone >98.0%(GC) | 42079-78-7 | 1g | $91 | 2024-03-01 | Buy |
| TCI Chemical | M2365 | 5-Methoxyflavone >98.0%(GC) | 42079-78-7 | 5g | $271 | 2024-03-01 | Buy |
| Alfa Aesar | B23700 | 5-Methoxyflavone, 97% | 42079-78-7 | 0.1g | $22 | 2021-12-16 | Buy |
| Alfa Aesar | B23700 | 5-Methoxyflavone, 97% | 42079-78-7 | 0.5g | $66.6 | 2021-12-16 | Buy |
| Alfa Aesar | B23700 | 5-Methoxyflavone, 97% | 42079-78-7 | 2.5g | $279 | 2021-12-16 | Buy |
5-METHOXYFLAVONE Chemical Properties,Uses,Production
Uses
5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation.
Definition
ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids.
Biological Activity
5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors.
in vitro
5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner.
in vivo
5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals.
target
| Target | Value |
| DNA polymerase β () |
5-METHOXYFLAVONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| R&D Scientific Inc. | +12266000236 | sales@rdscientific.com | Canada | 1245 | 58 |
View Lastest Price from 5-METHOXYFLAVONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | 5-methoxyflavone
42079-78-7
|
US $600.00 / g | 1g | 98 | 500 Kg | R&D Scientific Inc. | |
 |
2019-07-06 | 5-Methoxyflavone
42079-78-7
|
US $1.00 / kg | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- 5-methoxyflavone
42079-78-7
- US $600.00 / g
- 98
- R&D Scientific Inc.
-
- 5-Methoxyflavone
42079-78-7
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
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