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BOC-L-Isoleucine

BOC-L-Isoleucine structure

CAS No.: 13139-16-7

Chemical Name:: BOC-L-Isoleucine

Synonyms: BOC-ILE-OH;Boc-L-lle-OH;N-Boc-L-isoleucine;BOC-L-Ile;BOC-ISOLEUCINE;Boc-L-Isovaline;N-(tert-Butyloxycarbonyl)-L-isoleucine;Boc-lIe-OH;Boc-IIe-OH;Boc-Ile-OH1

CBNumber:: CB4690221

Molecular Formula:: C11H21NO4

Molecular Weight:: 231.29

MDL Number:: MFCD00038324

MOL File:: 13139-16-7.mol

MSDS File:: SDS

Last updated:2026-01-13 11:20:14

Product description	Number	Pack Size	Price
Boc-Ile-OH 98%	359653	25g	$128
N-(tert-Butoxycarbonyl)-L-isoleucine Hemihydrate >99.0%(T)	B1186	5g	$32
N-(tert-Butoxycarbonyl)-L-isoleucine Hemihydrate >99.0%(T)	B1186	25g	$79
N-Boc-L-isoleucine	B657225	100g	$200
N-Boc-L-isoleucine	458374	10g	$312
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BOC-L-Isoleucine Properties

Melting point	66-69 °C(lit.)
alpha	2 º (c=2,CH3COOH)
Boiling point	373.37°C (rough estimate)
Density	1.1202 (rough estimate)
refractive index	2.7 ° (C=2, AcOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Acetic Acid, DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.03±0.22(Predicted)
color	White to Off-White
optical activity	[α]20/D +2.7°, c = 2 in acetic acid
Water Solubility	Soluble in methanol. Insoluble in water.
BRN	1711700
Major Application	peptide synthesis
InChI	1S/C11H21NO4/c1-6-7(2)8(9(13)14)12-10(15)16-11(3,4)5/h7-8H,6H2,1-5H3,(H,12,15)(H,13,14)/t7-,8-/m0/s1
InChIKey	QJCNLJWUIOIMMF-YUMQZZPRSA-N
SMILES	CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(O)=O
CAS DataBase Reference	13139-16-7(CAS DataBase Reference)
EPA Substance Registry System	L-Isoleucine, N-[(1,1-dimethylethoxy)carbonyl]- (13139-16-7)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H315-H319

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

24/25-36-26

WGK Germany

TSCA

TSCA listed

HS Code

29241990

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

BOC-L-Isoleucine price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	359653	Boc-Ile-OH 98%	13139-16-7	25g	$128	2025-07-31	Buy
TCI Chemical	B1186	N-(tert-Butoxycarbonyl)-L-isoleucine Hemihydrate >99.0%(T)	13139-16-7	5g	$32	2025-07-31	Buy
TCI Chemical	B1186	N-(tert-Butoxycarbonyl)-L-isoleucine Hemihydrate >99.0%(T)	13139-16-7	25g	$79	2025-07-31	Buy
TRC	B657225	N-Boc-L-isoleucine	13139-16-7	100g	$200	2021-12-16	Buy
Usbiological	458374	N-Boc-L-isoleucine	13139-16-7	10g	$312	2021-12-16	Buy

Product number	Packaging	Price	Buy
359653	25g	$128	Buy
B1186	5g	$32	Buy
B1186	25g	$79	Buy
B657225	100g	$200	Buy
458374	10g	$312	Buy

BOC-L-Isoleucine Chemical Properties,Uses,Production

Chemical Properties

white fine crystalline powder

Uses

N-Boc-L-isoleucine is used to prepare BOC-L-isoleucine hydroxysuccinimide ester by using 1-hydroxybenzotriazole and 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride.

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

Synthesis

73-32-5

24424-99-5

13139-16-7

GENERAL STEPS: L-isoleucine (1.31 g, 10 mmol, 1.0 equiv) was dissolved in 20.5 mL of 1 M NaOH solution and cooled in an ice bath. Di-tert-butyl dicarbonate (Boc2O, 2.62 g, 12 mmol, 1.2 equiv) dissolved in 7 mL of dioxane was added slowly. The reaction mixture was stirred at ambient temperature for 24 hours. Subsequently, the pH of the reaction solution was adjusted to 10 with 1 M NaOH and ether was added for phase separation. The aqueous phase was acidified to pH 2 with 1 M HCl and extracted with ethyl acetate (EtOAc). The combined organic phases were washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give BOC-L-isoleucine as a colorless oil (2.20 g, 95% yield). IR (cm-1): 3292 (w), 2967 (m), 2934 (w), 2880 (w), 1713 (s), 1661 (m), 1504 (m), 1465 (w), 1394 (m), 1368 (s), 1242 (m), 1159 (s), 1121 (m), 1046 (m), 1019 (w), 857 (w), 778 857 (w), 778 (w), 657 (w). 1H NMR (500 MHz, CDCl3) δ: 0.94 (t, J = 7.3 Hz, 3H, H-6), 0.98 (d, J = 7 Hz, 3H, H-4), 1.15-1.29 (m, 1H, H-5a), 1.46 (s, 9H, H-9/10/11), 1.46-1.54 (m, partially overlapped, 1H, H-5b), 1.83-1.99 (m, 1H, H-3), 4.30 (dd, J = 8.9, 4.6 Hz, 1H, H-2), 5.02 (d, J = 8.9 Hz, 1H, NH). 13C NMR (125 MHz, CDCl3) δ: 11.8 (C-6), 15.7 (C-4), 25.0 (C-5), 28.5 (C-9/10/11), 37.9 (C-3), 58.0 (C-2), 80.2 (C-8), 155.9 (C-7), 177.2 (C-1). HRMS (ESI) m/z: [M-H]- calcd for C11H20NO4 230.13868, found 230.13926. [α]20D +3.6 (c 2.00, CH3OH) (Lit [3]: [α]25D +3.8 (c 1.01, CH3OH)).

References

[1] Tetrahedron Letters, 2005, vol. 46, # 38, p. 6537 - 6540
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6340 - 6350
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 14, p. 3573 - 3586
[4] Tetrahedron, 1992, vol. 48, # 37, p. 8007 - 8022
[5] Tetrahedron, 2006, vol. 62, # 31, p. 7274 - 7283

BOC-L-Isoleucine synthesis

Synthesis of BOC-L-Isoleucine from Di-tert-butyl dicarbonate

BOC-L-Isoleucine Preparation Products And Raw materials

Raw materials

Hexane L-Isoleucine Di-tert-butyl dicarbonate tert-Butanol Ethyl acetate

Acetic acid Sodium hydroxide 1,4-Dioxane

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Preparation Products

dolastatin 10 ANGIOTENSIN I, HUMAN ANGIOTENSIN II, HUMAN BOC-ILE-GLY-OME N-Boc-Val-Dil-Dap-Doe

(S)-N-BOC-LEUCINE-NITRILE

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BOC-L-Isoleucine Suppliers

Global( 388)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+8617390183901	cynthia@enlaibio.com	China	1098	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from BOC-L-Isoleucine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-13	BOC-L-Isoleucine 13139-16-7	US $0.00-0.00 / kg	1kg	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-02-02	Boc-Ile-OH 13139-16-7	US $0.00-0.00 / kg	1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-01-04	Boc-Ile-OH 13139-16-7	US $34.00 / mg			10g	TargetMol Chemicals Inc.

BOC-L-Isoleucine
13139-16-7
US $0.00-0.00 / kg
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-Ile-OH
13139-16-7
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Boc-Ile-OH
13139-16-7
US $34.00 / mg
TargetMol Chemicals Inc.

BOC-L-Isoleucine Spectrum

BOC-L-Isoleucine(13139-16-7)¹HNMR BOC-L-Isoleucine(13139-16-7)FT-IR BOC-L-Isoleucine(13139-16-7)IR BOC-L-Isoleucine(13139-16-7)Raman

13139-16-7(BOC-L-Isoleucine )Related Search:

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BOC-D-ISOLEUCINE extrapure,N-T-BOC-D-ISOLEUCINE,N-ALPHA-T-BOC-D-ISOLEUCINE,BOC-D-ISOLEUCINE Boc-L-isoleucine amide L-Isovaline

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BOC-L-ISOLEUCINE BOC-L-ISOLEUCINE-OH N-(TERT-BUTOXYCARBONYL)-L-ISOLEUCINE N-T-BOC-L-ISOLEUCINE N-ALPHA-T-BOC-L-ISOLEUCINE N-ALPHA-T-BUTOXYCARBONYL-L-ISOLEUCINE L-Isoleucine, N-[(1,1-dimethylethoxy)carbonyl]- (2S)-N-(tert-Butoxycarbonyl)-L-isoleucine (2S,3S)-2-[(tert-Butyloxycarbonyl)amino]-3-methylpentanoic acid N-(tert-Butoxycarbonyl)isoleucine BOC-L-ISOLEUCINE extrapure N-(tert-Butoxycarbonyl)-L-isoleucine, Boc-L-isoleucine N-(tert-Butoxycarbonyl)-L-isoleucine ,99% (S)-N-BOC-ISOLEUCINE L-ISOLEUCINE-N-T-BOC Boc-lle-OH·1/2 H2O Boc-L-isoleucine heMihydrate N-Boc-L-isoleucine Boc-Ile-OH (2S,3S)-2-((tert-Butoxycarbonyl)aMino)-3-Methylpentanoic acid (2S,3S)-2-((tert-Butoxycarbonyl)aMino)-3-Methylpentanoic acid/BOC-L-ILe-OH Boc-L-Isoleucine, 95+% Boc-Ile-OH1 Boc-Ile-OH 98% Boc-(2S,3S)-2-amino-3-methylpentanoic acid Boc-L-isoleucine≥ 99% (Assay) N-T-BOC-L-ISOLEUCINE CRYSTALLINE N-(TERT-BUTOXYCARBONYL)-L-ISOLEUCINE, 98 % Boc-Ile-OH.5H2O n-[(1,1-dimethylethoxy)carbonyl]-l-isoleucin BOC-L-Isoleucine, 99+% Boc-lle-OH.1/2H2O boc-ile-oh,0.5h20 N-ALPHA-T-BUTYLOXYCARBONYL-L-ISOLEUCINE SEMIHYDRATE Boc-L-isoleucine· 1/2H2O Boc-Isoleucine, 0.5 H2O Boc-Ile-OH.H2O N-tert-Butoxycarbonyl-L-isoleucine·1/2H2O N-tert-Butoxycarbonyl-L-isoleucine monohydrate N-Boc-L-isoleucine, 98+% Boc-Ile-OH·½H2O Isoleucine, N-carboxy-, N-tert-butyl ester, L- 3-methyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid hydrate Boc-L-isoleucine, Anhydrous N-(tert-Butoxycarbonyl)-L-isoleucine Hemihydrate> BOC-L-Isoleucine USP/EP/BP N-(TERT-BUTOXYCARBONYL)-L-ISOLEUNICE HEM IHYDRATE BOC-ISOLEUCINE BOC-ILE-OH N-(tert-Butyloxycarbonyl)-L-isoleucine BOC-L-Ile Boc-L-Isovaline N-Boc-L-isoleucine Boc-L-lle-OH Boc-L-Isoleucin Boc-lIe-OH (Tert-butoxycarbonyl)-L-isoleucine BOC-L-Isoleucine-OH 98% Boc-Ile-OH/98%/13139-16-7 Boc-IIe-OH