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p-Acetotoluidide

p-Acetotoluidide
p-Acetotoluidide structure
CAS No.
103-89-9
Chemical Name:
p-Acetotoluidide
Synonyms
NSC 7644;4-Acetotoluide;p-Acetotoluide;p-Tolyacetamide;P-TOLYLACETAMIDE;P-ACETOTOLUIDINE;P-ACETOTOLUIDIDE;ACET-P-TOLUIDINE;4-ACETOTOLUIDINE;4-Acetotoluidide
CBNumber:
CB4703774
Molecular Formula:
C9H11NO
Formula Weight:
149.19
MOL File:
103-89-9.mol

p-Acetotoluidide Properties

Melting point:
149-151 °C(lit.)
Boiling point:
307 °C(lit.)
Density 
1.21
vapor density 
5.14
refractive index 
1.5279 (estimate)
Flash point:
168 °C
storage temp. 
Store below +30°C.
solubility 
1.2g/l (experimental)
form 
Crystals or Crystalline Powder
pka
15.13±0.70(Predicted)
color 
Beige to light brown
Water Solubility 
1 g/L (25 ºC)
Merck 
14,74
BRN 
607036
InChIKey
YICAMJWHIUMFDI-UHFFFAOYSA-N
CAS DataBase Reference
103-89-9(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
N36D4JN82T
NIST Chemistry Reference
Acetamide, N-(4-methylphenyl)-(103-89-9)
EPA Substance Registry System
p-Acetotoluidide (103-89-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS06
Signal word  Warning
Hazard statements  H301-H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338-P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P280a-P301+P310a-P405-P501a
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  AN2930000
TSCA  Yes
HS Code  29242995
Toxicity LD50 orl-rat: 2640 mg/kg MarJV# 29MAR77
NFPA 704
1
2 0

p-Acetotoluidide price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 307076 4′-Methylacetanilide 99% 103-89-9 10g $22.1 2021-03-22 Buy
Sigma-Aldrich 307076 4′-Methylacetanilide 99% 103-89-9 100g $61.2 2021-03-22 Buy
Sigma-Aldrich 8.00077 4′-Methylacetanilide for synthesis 103-89-9 250 g $119.32 2021-03-22 Buy
TCI Chemical A0064 p-Acetotoluidine >98.0%(GC) 103-89-9 25g $49 2021-03-22 Buy
TCI Chemical A0064 p-Acetotoluidine >98.0%(GC) 103-89-9 100g $143 2021-03-22 Buy

p-Acetotoluidide Chemical Properties,Uses,Production

Description

p-Acetotoluidide is an off-white to brown flake, odourless, solid or crystalline powder (pure form), which is soluble in hot water, alcohol, ether, chloroform, acetone, glycerol, and benzene. It is combustible and undergoes self-ignition (at 5450°C) but is otherwise stable under most conditions. p-Acetanilide on decomposition releases carbon monoxide, oxides of nitrogen, carbon dioxide, and toxic fumes. p-Acetanilide is used as an inhibitor of peroxides and stabiliser for cellulose ester varnishes. It is used as an intermediate for the synthesis of rubber accelerators, dyes and dye intermediate, and camphor. It is also used as a precursor in penicillin synthesis and other pharmaceuticals including painkillers and intermediates. Phenylacetamide structure shows analgesic and antipyretic effects. But acetanilide is not used directly for this application due to causing methemoglobinemia (the presence of excessive methemoglobin which does not function reversibly as an oxygen carrier in the blood).

Chemical Properties

BEIGE TO LIGHT BROWN CRYSTALS OR CRYST. POWDER

Chemical Properties

p-Acetotoluidide is an off-white to brown fl ake, odorless, solid or crystalline powder (pure form), soluble in hot water alcohol, ether, chloroform, acetone, glycerol, and benzene. It is combustible and undergoes self-ignition (at 545°C), but is otherwise stable under most conditions. On decomposition, p-acetanilide releases carbon monoxide, oxides of nitrogen, carbon dioxide, and toxic fumes. p-Acetanilide is used as an inhibitor of peroxides and a stabilizer for cellulose ester varnishes. It is used as an intermediate for the synthesis of rubber accelerators, dyes and dye intermediate, and camphor. It is also used as a precursor in penicillin synthesis and other pharmaceuticals, including painkillers and intermediates. Phenylacetamide structure shows analgesic and antipyretic effects. But acetanilide is not used directly for this application because it causes methemoglobinemia (the presence of excessive methemoglobin that does not function reversibly as an oxygen carrier in the blood).

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 5092, 1955 DOI: 10.1021/ja01624a042
Organic Syntheses, Coll. Vol. 1, p. 111, 1941
Synthesis, p. 118, 1977

General Description

Colorless needles.

Air & Water Reactions

Water insoluble.

Reactivity Profile

4'-Methylacetanilide is an amide. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 4'-Methylacetanilide emits toxic fumes.

Health Hazard

Exposures to p-acetotoluidide through ingestion or inhalation cause potential health effects. The symptoms of toxicity include, but are not limited to, irritation to the eyes and redness of the skin, wheezing, cough, shortness of breath, or burning in the mouth, throat, or chest, and respiratory tract irritation.

Safety Profile

Moderately toxic by ingestion. See also ACETANILIDE. Combustible. When heated to decomposition it emits toxic fumes of NO,. To fight fire, use water, foam, CO2, dry chemical

storage

p-Acetanilide should be kept stored in a cool, dry place with the container closed when not in use

Purification Methods

Crystallise it from aqueous EtOH. [Beilstein 12 H 920, 12 I 420, 12 II 501, 12 III 2051, 12 IV 1902.]

Precautions

During handling and use of p-aetotoluidide, proper personal protective equipment should be worn. Avoid contact with the eyes, skin, and clothing. Avoid ingestion and inhalation. On accidental exposure at the workplace, workers should immediately fl ush the eyes and exposed part of the body with plenty of water. Workers should avoid using the contaminated clothing and shoes.

p-Acetotoluidide Preparation Products And Raw materials

Raw materials

Preparation Products


p-Acetotoluidide Suppliers

Global( 131)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29865 58
Fuxin Pharmaceutical
021-50872116
contact@fuxinpharm.com CHINA 9520 58
Neostar United (Changzhou) Industrial Co., Ltd.
+0086-519-85557386
+0086-519-85557389 marketing1@neostarunited.com CHINA 4135 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17607 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37441 58
WinWin Chemical CO., Limited
15325081899 0086-577-64498589
0086-577-56994596 sales@win-winchemical.com CHINA 11942 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58

View Lastest Price from p-Acetotoluidide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-12-26 p-Acetotoluidide
103-89-9
US $1.00 / KG 1KG 99% 800kg Career Henan Chemical Co

p-Acetotoluidide Spectrum


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