HUMAN TNF-ALPHA
- CAS No.
- 94948-59-1
- Chemical Name:
- HUMAN TNF-ALPHA
- Synonyms
- hTNF-α;CACHECTIN;HUMAN DIF;TNF ALPHA;Tasonermin;HTNF-ALPHA;TNF, HUMAN;HUMAN TNF-A;RHTNF-ALPHA;HUMAN TNFSF2
- CBNumber:
- CB4704832
- Molecular Formula:
- NULL
- Molecular Weight:
- 0
- MDL Number:
- MFCD00148692
- MOL File:
- Mol file
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| form | powder |
| color | colorless |
| FDA UNII | 23CA79S88F |
| ATC code | L03AX11 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| WGK Germany | 3 |
| RTECS | MT6435000 |
HUMAN TNF-ALPHA price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T6674 | Tumor Necrosis Factor-α human TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture | 94948-59-1 | 10μg | $159.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | T6674 | Tumor Necrosis Factor-α human TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture | 94948-59-1 | 5x10μg | $1680 | 2024-03-01 | Buy |
| Sigma-Aldrich | H8916 | Tumor Necrosis Factor-α human TNF-α, recombinant, expressed in HEK 293 cells, suitable for cell culture | 94948-59-1 | 10μg | $163 | 2024-03-01 | Buy |
| Alfa Aesar | J67162 | Tumor Necrosis Factor-alpha human | 94948-59-1 | 10microg | $104 | 2023-06-20 | Buy |
| Alfa Aesar | J67162 | Tumor Necrosis Factor-alpha human | 94948-59-1 | 50microgram | $208 | 2023-06-20 | Buy |
HUMAN TNF-ALPHA Chemical Properties,Uses,Production
Description
Tasonermin was launched in Germany for the treatment of soft tissue sarcoma of the limbs. Recent literature is scarce for this compound. It is the first tumor necrosis factor (TNF) launched for cancer treatment to date and works through destruction of tumor blood vessels. This recombinant protein is expressed in E. coil and purified. Tasonermin is too toxic for systemic use and consequently is being used in isolated limb perfusion (ILP) for sarcoma and malignant melanoma. The product has shown notable efficacy when used in combination with melphalan to prevent amputation. In four European clinical trials involving 260 patients destined for amputation or mutilating surgery, Beromun enabled durable limb salvage in 80% of the patients. Due to the complexity of ILP, the application of tasonermin is restricted to clinical centers with sufficient experience and facilities including radionucleide-based continuous monitoring of leakage from the isolated circuit during ILP and postoperative intensive care surveillance.
Originator
Genentech (US)
Uses
Tumor Necrosis Factor-a human has been used:
- as a permeability inducing agent for endothelial cell monolayer permeability assay
- as a reactive oxygen species inducer in primary rat cardiac microvascular endothelial cells (RCMVECs)
- in the activation of nuclear factor kappa B (NF-κB) in human embryonic kidney cells (HEK293), neuroblastoma SH-SY5Y cells and HeLa cells
- in the stimulation of the human keratinocyte cell line(HaCaT) and human coronary artery endothelial cells (HCAECs)
Uses
TNF-α include stimulating growth of human fibroblasts and other cell lines activating polymorphonuclear neutrophils and osteoclasts and inducing interleukin-1, prostaglandin E2, and collagenase production.
brand name
Beromun
General Description
The TNFα (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33. TNFα is a member of TNF superfamily. TNF-α has a palmitoyl group in the cysteine residue and is phosphorylated in the transmembrane region serine residue.
Biochem/physiol Actions
Tumor Necrosis Factor-α (TNF-α) is a potent pro-inflammatory cytokine that plays a role in the rheumatoid arthritis pathology, psoriatic arthritis (PsA) and psoriasis. It stimulates interleukins IL-1 and IL-6. Polymorphism in the TNF-α gene is associated with destructive arthropathy in PsA. The post-translational modifications in TNF-a is crucial for its functionality.
HUMAN TNF-ALPHA Preparation Products And Raw materials
Raw materials
Preparation Products
HUMAN TNF-ALPHA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696; | info@hanhongsci.com | China | 42982 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Beijing OKA biological technology co., LTD | 010-62971590 18548936886 | 3462612863@qq.com | China | 6912 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 31183 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| amyjetsci | 027-59626688 18771149750 | sales@amyjet.com | China | 3004 | 58 |
| JiangSu Star Science Co.,Ltd | 400-605-7200 17312445705 | sales022@b2star.com | China | 3764 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
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