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TOLBUTAMIDE

TOLBUTAMIDE
TOLBUTAMIDE structure
CAS No.
64-77-7
Chemical Name:
TOLBUTAMIDE
Synonyms
IRKG;d860;IRK16;GIRK4;BZ 55;D 860;u2043;KCNJ16;Diaben;Drabet
CBNumber:
CB4709039
Molecular Formula:
C12H18N2O3S
Formula Weight:
270.35
MOL File:
64-77-7.mol

TOLBUTAMIDE Properties

Melting point:
128-130°C
Density 
1.2450
refractive index 
1.6360 (estimate)
storage temp. 
Refrigerator
solubility 
Soluble in chloroform.
pka
pKa 5.32(H2O t = 37) (Uncertain)
form 
neat
Merck 
14,9507
BRN 
1984428
Stability:
Stable. Combustible.
CAS DataBase Reference
64-77-7(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,Xn
Risk Statements  20/21/22-40-43-36-11
Safety Statements  26-36/37/39-36/37-16-24/25
WGK Germany  2
RTECS  YS4550000
TSCA  Yes
HS Code  29350090
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P321 Specific treatment (see … on this label).
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.

TOLBUTAMIDE price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46968 Tolbutamide VETRANAL 64-77-7 250mg-r $46.4 2018-11-20 Buy
Sigma-Aldrich 1670003 Tolbutamide United States Pharmacopeia (USP) Reference Standard 64-77-7 200mg $338.1 2018-11-20 Buy
TCI Chemical T3690 Tolbutamide >98.0%(HPLC)(T) 64-77-7 1g $39 2018-11-22 Buy
Alfa Aesar B21698 Tolbutamide, 98% 64-77-7 10g $45.9 2018-11-13 Buy
Alfa Aesar B21698 Tolbutamide, 98% 64-77-7 50g $153 2018-11-13 Buy

TOLBUTAMIDE Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

An antidiabetic, used as a hypoglycemic agent in veterinary medicine.

Definition

ChEBI: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.

General Description

Tolbutamide is N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide;or 1-butyl-3-(p-tolylsulfonyl)urea (Orinase,generic). Orinase Diagnostic was the sodium salt, which isfreely soluble in water for injection, but this product was discontinuedc. 2000.

General Description

Tolbutamide, 1-butyl-3-(p-tolylsulfonyl)urea (Orinase), occurs as a white, crystalline powderthat is insoluble in water and soluble in alcohol or aqueousalkali. It is stable in air.
Tolbutamide is absorbed rapidly in responsive diabetic patients.The blood sugar level reaches a minimum after 5 to8 hours. It is oxidized rapidly in vivo to 1-butyl-3-(p-carboxyphenyl)sulfonylurea, which is inactive. The metabolite isfreely soluble at urinary pH; if the urine is strongly acidified,however, as in the use of sulfosalicylic acid as a protein precipitant,a white precipitate of the free acid may be formed.

General Description

White crystals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

TOLBUTAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). TOLBUTAMIDE is incompatible with acids. .

Fire Hazard

Flash point data for TOLBUTAMIDE are not available. TOLBUTAMIDE is probably combustible.

Clinical Use

Tolbutamide should be used only when the diabetic patientis an adult or shows adult-onset diabetes, and the patientshould adhere to dietary restrictions.

Safety Profile

Moderately toxic by ingestion and several other routes. A human teratogen. Human reproductive effects by ingestion and possibly other routes: stillbirth, developmental abnormalities of the cardlovascular (circulatory) system and urogenital system, and unspecified neonatal effects. Human systemic effects by ingestion: nausea or vomiting, hypoglycemia. Other experimental teratogenic and reproductive effects. Mutation data reported. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of NO, and SOx.

TOLBUTAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products


TOLBUTAMIDE Suppliers

Global( 135)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23958 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20084 58
Hubei xin bonus chemical co. LTD
13657299721
zhangyuzhu@xhlchem.com CHINA 17424 58
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
+86-21-57758967 sales@boylechem.com China 2214 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40275 62
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30168 84
TAIYUAN RHF CO.,LTD. +86 351 7031519
+86 351 7031519 sales@RHFChem.com China 2349 56

View Lastest Price from TOLBUTAMIDE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-11 TOLBUTAMIDE
64-77-7
US $1.00 / KG 1KG 99% 25kg career henan chemical co

TOLBUTAMIDE Spectrum


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