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Nalpha-FMOC-L-Glutamine

Nalpha-FMOC-L-Glutamine structure

CAS No.: 71989-20-3

Chemical Name:: Nalpha-FMOC-L-Glutamine

Synonyms: FMOC-GLN-OH;FMOC-GLN;FMOC-L-GLN-OH;FMOC-L-GLUTAMINE;FMOC-L-GLN;Fmoc-GIn-OH;Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine;NSC334303;Fmoc-Gln-0H;FMOC-GLUTAMINE

CBNumber:: CB4714259

Molecular Formula:: C20H20N2O5

Molecular Weight:: 368.38

MDL Number:: MFCD00037137

MOL File:: 71989-20-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:39:19

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Nalpha-FMOC-L-Glutamine Properties

Melting point	220 °C (dec.)(lit.)
alpha	-18 º (c=1,DMF)
Boiling point	498.73°C (rough estimate)
Density	1.3116 (rough estimate)
refractive index	-18 ° (C=1, DMF)
storage temp.	2-8°C
solubility	almost transparency in N,N-DMF
form	powder to crystal
pka	3.73±0.10(Predicted)
color	White to Almost white
optical activity	[α]20/D 18.5±1.5°, c = 1% in DMF
BRN	4722773
Major Application	peptide synthesis
InChI	1S/C20H20N2O5/c21-18(23)10-9-17(19(24)25)22-20(26)27-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H2,21,23)(H,22,26)(H,24,25)/t17-/m0/s1
InChIKey	IZKGGDFLLNVXNZ-KRWDZBQOSA-N
SMILES	NC(=O)CC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
CAS DataBase Reference	71989-20-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

24/25-36/37/39-27-26

WGK Germany

HazardClass

IRRITANT

HS Code

29242990

Storage Class

13 - Non Combustible Solids

NFPA 704

	0
1		0

Nalpha-FMOC-L-Glutamine price More Price(76)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.52205	Fmoc-Gln-OH Novabiochem?	71989-20-3	25g	$77.3	2026-04-30	Buy
Sigma-Aldrich	8.52205	Fmoc-Gln-OH Novabiochem?	71989-20-3	100g	$238	2026-04-30	Buy
Sigma-Aldrich	8.52205	Fmoc-Gln-OH Novabiochem?	71989-20-3	5G	$27.2	2025-07-31	Buy
TCI Chemical	F0308	Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine >98.0%(HPLC)	71989-20-3	1g	$19	2026-04-30	Buy
TCI Chemical	F0308	Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine >98.0%(HPLC)	71989-20-3	5g	$46	2026-04-30	Buy

Product number	Packaging	Price	Buy
8.52205	25g	$77.3	Buy
8.52205	100g	$238	Buy
8.52205	5G	$27.2	Buy
F0308	1g	$19	Buy
F0308	5g	$46	Buy

Nalpha-FMOC-L-Glutamine Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

N2-Fmoc-L-glutamine is an N-Fmoc-protected form of L-Glutamine (G597000). L-Glutamine is a non-essential amino acid that is important for cells that proliferate quickly in the body, such as those of the immune system. L-Glutamine is known to be especially important for the gut, as it helps to maintain intestinal structure and function. L-Glutamine also has protective properties against host toxicity of chemotherapy in cancer patients.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

56-85-9

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

82911-69-1

71989-20-3

To a stirred solution of L-glutamine (1.75 g, 12 mmol) and sodium carbonate (1.27 g, 12 mmol) in 30 mL of water, a solution of 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu, 3.0 g, 8.9 mmol) dissolved in 60 mL of tetrahydrofuran (THF) was slowly added. The reaction mixture was stirred overnight at room temperature. Subsequently, THF was removed by distillation under reduced pressure. the residue was diluted with 100 mL of 1N hydrochloric acid and the precipitated white solid was collected by filtration. The solid was further recrystallized in a mixed aqueous solution of DMF with 0.1 N hydrochloric acid to afford the target product (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-amino-5-oxopentanoic acid as a white powder (2.76 g, 84% yield). The product was characterized by 1H-NMR (90 MHz, DMSO-d6) with chemical shifts of 12.47 (1H, s), 7.89-7.20 (10H, m), 6.68 (1H, s, br), 4.22-3.90 (4H, m), and 2.25-1.86 (4H, m).

References

[1] Journal of Peptide Science, 2017, vol. 23, # 3, p. 202 - 214
[2] Patent: US2006/161007, 2006, A1. Location in patent: Page/Page column 12
[3] Synthetic Communications, 2009, vol. 39, # 11, p. 2022 - 2031

Nalpha-FMOC-L-Glutamine synthesis

Synthesis of Nalpha-FMOC-L-Glutamine from L-Glutamine and Fmoc-OSu

Nalpha-FMOC-L-Glutamine Preparation Products And Raw materials

Raw materials

L-Glutamine Fmoc-OSu Sodium carbonate Tetrahydrofuran Water

Preparation Products

MELITTIN

Nalpha-FMOC-L-Glutamine Suppliers

Global Suppliers ( 408)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Sichuan Tongsheng Amino acids Co.,Ltd.	0838-2274206 17340404235	sales@biots.cn	China	300	66
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	45000	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
Sichuan Tongsheng Amino acids Co.,Ltd.	66
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66

View Latest Price from Nalpha-FMOC-L-Glutamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-10-12	N-Fmoc-L-Glutamine 71989-20-3	$5.00	1kg	≥99%	100mt/year	Jinan Finer Chemical Co., Ltd
2026-10-09	Nalpha-FMOC-L-Glutamine 71989-20-3		1kg	98%min	500kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-30	Fmoc-L-Gln-OH 71989-20-3		1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd

N-Fmoc-L-Glutamine
71989-20-3
$5.00
≥99%
Jinan Finer Chemical Co., Ltd

Nalpha-FMOC-L-Glutamine
71989-20-3
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Fmoc-L-Gln-OH
71989-20-3
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Nalpha-FMOC-L-Glutamine Spectrum

Nalpha-FMOC-L-Glutamine(71989-20-3)MS Nalpha-FMOC-L-Glutamine(71989-20-3)¹HNMR Nalpha-FMOC-L-Glutamine(71989-20-3)¹³CNMR Nalpha-FMOC-L-Glutamine(71989-20-3)IR1 Nalpha-FMOC-L-Glutamine(71989-20-3)IR2

71989-20-3 (Nalpha-FMOC-L-Glutamine) Related Search:

Boc-D-Glutamine L-Alanyl-L-Glutamine L-Glutamine Glycyl-L-glutamine monohydrate Fmoc-Aib-OH

Transglutaminase 9-Fluorenylmethyl chloroformate Fmoc-OSu Fmoc-L-aspartic acid Fmoc-D-Asn(Trt)-OH

Fmoc-Gly-OH Fmoc-D-phenylalanine Fmoc-Met-OH FMOC-L-Methionine Fmoc-D-leucine

Fmoc-D-tryptophan Fmoc-5-aminopentanoic acid Fmoc-D-Tyr(tBu)-OH

1of4

N-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMINE N-ALPHA-FMOC-L-GLUTAMINE N-ALPHA-FMOC-L-GLN 9-FLUORENYLMETHOXYCARBONYL-L-GLUTAMINE n(alpha)-fluorenylmethoxycarbonylglutamine NSC334303 L-GLUTAMINE-N-FMOC (13C5,15N2) Fmoc-L-glutamine≥ 99% (HPLC, Chiral purity) N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine N-α-Fmoc-L-glutamine NA-FMOC-L-GLUTAMINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-& L-Glutamine-UL-13C5,UL-15N2-N-FMOC FMOC-L-GLUTAMINE extrapure 5-Amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid N2-(9H-Fluorene-9-ylmethoxycarbonyl)-L-glutamine Nα-(9H-Fluorene-9-ylmethoxycarbonyl)-L-glutamine Nalpha-FMOC-L-Glutamine,98% N-(9-Fluorenylmethyloxycarbonyl)-L-glutamine ,98% Nalpha-FMOC-L-Glutam Fmoc-Glutamine-OH L-GLUTAMINE-N-FMOC (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-amino-5-oxopentanoic acid Nalpha-Fmoc-L-glutamine Fmoc-Gln-OH 4-Carbamoyl-2-([(9H-fluoren-9-ylmethoxy)carbonyl]amino)butanoic acid 5-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-keto-valeric acid 5-amino-2-[(9H-fluoren-9-ylmethoxy-oxomethyl)amino]-5-oxopentanoic acid FMOC-GLUTAMINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GLUTAMINE NALPHA-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-GLUTAMINE N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-GLUTAMINE N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMINE (9H-Fluoren-9-yl)MethOxy]Carbonyl Gln-OH (2S)-4-carbamoyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine> L-Glutamine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]- Nalpha-FMOC-L-Glutamine USP/EP/BP Fmoc-L-glutamine, puriss, 99% TIANFU-CHEM Nalpha-FMOC-L-Glutamine (2S)-5-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid Fmoc-Gln-0H Na-(9-Fluorenylmethoxycarbonyl)-L-glutamine Nα-Fmoc-L-glutamine FMOC-L-GLN-OH FMOC-L-GLN FMOC-GLN-OH FMOC-GLN Fmoc-GIn-OH FMOC-L-GLUTAMINE Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine 71989-20-3 7198-20-3 71686-20-3 C20H20N2O5 H2NCOCH22CHNHFMOCCOOH C20H19N2O5 Glutamine