5-Bromo-2-chloropyrimidine
- CAS No.
- 32779-36-5
- Chemical Name:
- 5-Bromo-2-chloropyrimidine
- Synonyms
- 2-CHLORO-5-BROMOPYRIMIDINE;2C5BP;5-Bromo-2-chL;Macitentan Impurity 27;5-BROMO-2-CHLOROPYRIMIDNE;Macitentan Intermediate 5;-bromo-2-chloropyrimidine;5-bromo-2-chlorpyrimidine;5-BROMO-2-CHLOROPYRIMIDINE;2-chloro -5-broMo - uracil
- CBNumber:
- CB4748175
- Molecular Formula:
- C4H2BrClN2
- Molecular Weight:
- 193.43
- MDL Number:
- MFCD00483232
- MOL File:
- 32779-36-5.mol
- MSDS File:
- SDS
Melting point | 73-79 °C (lit.) |
---|---|
Boiling point | 95°C 15mm |
Density | 1.859±0.06 g/cm3(Predicted) |
Flash point | 95°C/15mm |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | soluble in Methanol |
pka | -2.84±0.22(Predicted) |
form | Crystalline Powder |
color | Off-white to beige |
Water Solubility | insoluble |
BRN | 507955 |
Stability | Hygroscopic |
InChI | InChI=1S/C4H2BrClN2/c5-3-1-7-4(6)8-2-3/h1-2H |
InChIKey | XPGIBDJXEVAVTO-UHFFFAOYSA-N |
SMILES | C1(Cl)=NC=C(Br)C=N1 |
CAS DataBase Reference | 32779-36-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36/39-37/39-36 | |||||||||
RIDADR | UN 3335 | |||||||||
WGK Germany | 3 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29335990 | |||||||||
NFPA 704 |
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5-Bromo-2-chloropyrimidine price More Price(43)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 596949 | 5-Bromo-2-chloropyrimidine 96% | 32779-36-5 | 1g | $10.64 | 2024-03-01 | Buy |
TCI Chemical | B2847 | 5-Bromo-2-chloropyrimidine >97.0%(GC) | 32779-36-5 | 1g | $18 | 2024-03-01 | Buy |
TCI Chemical | B2847 | 5-Bromo-2-chloropyrimidine >97.0%(GC) | 32779-36-5 | 5g | $26 | 2024-03-01 | Buy |
Alfa Aesar | L18360 | 5-Bromo-2-chloropyrimidine, 98+% | 32779-36-5 | 5g | $109.65 | 2024-03-01 | Buy |
Alfa Aesar | L18360 | 5-Bromo-2-chloropyrimidine, 98+% | 32779-36-5 | 1g | $31.6 | 2022-04-27 | Buy |
5-Bromo-2-chloropyrimidine Chemical Properties,Uses,Production
Chemical Properties
Off-white to beige crystalline powder
Uses
5-Bromo-2-chloropyrimidine is applied as a pharmaceutical intermediate, in the synthesis of pharmaceutical goods such as inhibitors. It is also employed in the cross-coupling reactions of indium organometallics with 2,5-dihalopyrimidines.
Uses
5-Bromo-2-chloropyrimidine is a intermediate in the synthesis of pharmaceutical goods such as inhibitors.
Preparation
Under nitrogen protection, 35 g (0.2 mol) of 2-hydroxy-5-bromopyrimidine, 61.3 g (0.4 mol) of phosphorus oxychloride, and 200 mL of toluene were added into the reaction flask. At 35 ℃, triethylamine 40.5g was added and then heated up at 80-85 ℃. Stir the reaction for 6 hours, sampling HPLC to detect the raw material (less than 2%), and lower the temperature. After concentrating the mixture under reduced pressure to remove most of the toluene and Phosphorus oxychloride, put the reaction solution into 10°C water, and adjust pH=8-9 with 20% sodium carbonate aqueous solution. Finally, 5-Bromo-2-chloropyrimidine was obtained after purification.
Reactivity Profile
5-Bromo-2-chloropyrimidine, a 2,5-dihalopyrimidine, is a useful organic electrophiles. It could react with tri(3-indolyl)indium reagent through cross-coupling reaction. Other aryl- and heteroarylindium
reagents, such as thiophenyl-, pyridyl-, naphthyl-, and
alkynylindium reagents, also reacted with 5-bromo-2-
chloropyrimidine to afford the corresponding 2-chloro-5-substituted pyrimidines[1].
References
[1] Mosquera A, et al. Cross-Coupling Reactions of Indium Organometallics with 2,5-Dihalopyrimidines: Synthesis of Hyrtinadine A?. Organic Letters, 2008; 10: 3745–3748.
5-Bromo-2-chloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Changzhou Fullone Chemical Co., Ltd. | +86-13328197671 +86-13861172460 | sales@borenchem.cn | China | 1055 | 58 |
Shenyang TYSChem Co., Ltd. | +86-24-83607930 +8618640359690 | sales@honghuchem.com | China | 403 | 58 |
Changzhou Chontech Baocheng Chemical Co.,Ltd | +86-51982698291; +undefined15295095616 | info@hhbhswkj.com | China | 73 | 58 |
Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
Seasons Biotechnology Co., Ltd. | +86-0576-89232655 +86-13566878689 | info@seasonsbio.com | China | 46 | 58 |
ChemExpress | +86-021-58950125 | info@chemexpress.com | China | 557 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 2259 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
View Lastest Price from 5-Bromo-2-chloropyrimidine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-24 | 5-Bromo-2-chloropyrimidine
32779-36-5
|
US $5.00 / kg | 1kg | 99.92% | 50000tons | Ouhuang Engineering Materials (Hubei) Co., Ltd | ||
2024-01-11 | 5-Bromo-2-chloropyrimidine
32779-36-5
|
US $122.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2023-07-19 | 5-Bromo-2-chloropyrimidine
32779-36-5
|
US $30.00 / KG | 1KG | 99% | 20 Tons | Wuhan wingroup Pharmaceutical Co., Ltd |
- 5-Bromo-2-chloropyrimidine
32779-36-5
- US $5.00 / kg
- 99.92%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
- 5-Bromo-2-chloropyrimidine
32779-36-5
- US $122.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
- 5-Bromo-2-chloropyrimidine
32779-36-5
- US $30.00 / KG
- 99%
- Wuhan wingroup Pharmaceutical Co., Ltd
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